A5100344236- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Natural Antidiabetic Agents Studies
- Hepatitis B Virus Studies
- Pancreatic function and diabetes
- Diabetes Management and Education
- Gut microbiota and health
- MicroRNA in disease regulation
- Diabetes Treatment and Management
- Vitamin D Research Studies
- Diet, Metabolism, and Disease
- Circular RNAs in diseases
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetic Foot Ulcer Assessment and Management
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Hepatitis C virus research
- PI3K/AKT/mTOR signaling in cancer
- Photochemistry and Electron Transfer Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Calpain Protease Function and Regulation
China Three Gorges University
2022
Yichang Central People's Hospital
2022
First Affiliated Hospital of Zhengzhou University
2011-2022
Quest Diagnostics (United States)
2021
Central South University
2021
Chongqing Medical University
2021
Xiangya Hospital Central South University
2021
Affiliated Hospital of Southwest Medical University
2019
Nanjing Medical University
2018
Zhengzhou University
2012
Abstract Background Autoimmune thyroid disease (AITD) is a common organ‐specific autoimmune disorder, and genetic, environmental, endogenous factors are responsible for initiation of autoimmunity. Some AITD patients suffer from certain degree glucose‐lipid metabolism disorder. This study aims to explore the changes in metabolism, insulin resistance, inflammatory with AITD. Methods A total 91 Hashimoto's thyroiditis were retrospectively analyzed divided into hypothyroidism group (n = 42)...
Emerging evidence showed that muscone could improve chronic inflammation after myocardial infarction and protect alcohol-induced osteonecrosis of the femoral head. However, function on diabetic peripheral neuropathy (DPN) is obscure.The neuronal Schwann cell RSC 96 cells were treated with 125 mmol/l glucose to simulate in DPN. The viability was detected by counting kit-8. cycle apoptosis determined flow cytometry. expression marker proteins apoptosis, autophagy AKT/mTOR signalling pathway...
Aging is a complex process which accompanied by multiple related chronic diseases.
Kinesin family member 26B (KIF26B) is unveiled acted as important role in many solid tumors, however, the function of KIF26B hepatocellular carcinoma (HCC) unclear.The expression HCC tissues and cell lines were measured with immunochemistry, real-time PCR western blotting. The correlation between clinicopathological characteristics analyzed by SPSS19.0. Functional experiments was conducted CCK-8, transwell, EDU, colony formation vitro tumorigenesis vivo. gene set enrichment analysis used to...
Abstract Background The altered gut microbiota is implicated in the pathogenesis of liver fibrosis. Resveratrol a candidate for treatment fibrosis, which could ameliorate dysregulation mice. This study aimed to clarify role and mechanism resveratrol during Methods A mouse model fibrosis induced by CCl 4 was conducted assess effect on changes fibrotic mice after intervention were assessed using 16S ribosomal RNA sequencing. investigated Sirius red staining, immunohistochemical assay,...
The morbidity and prevalence of type 2 diabetes mellitus (DM) are increasing in the elderly population. Interleukin 37 (IL-37) play important roles anti-inflammatory anti-bacteria immune responses, but its role development DM is unclear. Therefore, we investigated whether IL-37 associated with underlying mechanism. Hospitalized patients (aged 65–95 years) recently diagnosed were studied retrospectively compared healthy subjects without glucose metabolism abnormalities. A diabetic mouse model...
Glucose tolerance progressively declines with age, and there is a high prevalence of type 2 diabetes in the elderly people. Previous studies have reported sex differences risk for diabetes, especially people, whereas reasons these remain poorly understood. This study aims to evaluate effect on glucose-stimulated insulin secretion mitochondrial function pancreatic beta cells Wistar rats.3-month-old 18-month-old rats both sexes were used. Insulin islets was analyzed by islet perifusion assays;...
Abstract Insulin-like growth factor-I receptor (IGF-IR) signaling is required for carcinogenicity and proliferation of gastrointestinal (GI) cancers. In this study, we sought to evaluate the effect a new tyrosine kinase inhibitor IGF-IR, NVP-AEW541, on signal transduction progression GI carcinomas. We assessed NVP-AEW541 transduction, proliferation, survival, migration in four cancer cells: colorectal adenocarcinoma HT29, pancreatic BxPC3, esophageal squamous cell carcinoma TE1, hepatoma...
Insulin-like growth factor (IGF)-I receptor (IGF-IR) signaling is required for carcinogenicity and proliferation of gastrointestinal cancers. We have previously shown successful targeting therapy colorectal, pancreatic, gastric, esophageal carcinomas using recombinant adenoviruses expressing dominant negative IGF-IR. Mutation in k-ras one key factors In this study, we sought to evaluate the effect a new monoclonal antibody IGF-IR, figitumumab (CP-751,871), on progression human with/without...
Abstract Background CCL22 played critical roles in Tregs recruitment. The upstream regulators modulating hepatocellular carcinoma (HCC) were not clearly understood. Methods MiR‐23a, p‐p65, p65, CCL22, and Foxp3 levels monitored by RT‐qPCR western blotting. Immunofluorescence assay was used to perform the costaining of CD4 on liver tissues. Transwell applied evaluate migration ability Tregs. Dual‐luciferase performed determine relationship miR‐23a/CCL22 p65/miR‐23a. Chromatin...
Oleanolic acid (OL) is a pentacyclic triterpene compound used for the treatment of hepatitis, liver fibrosis and cirrhosis. In China, there no published research on effect or biological utilization OL diseases. The aim present study was to investigate protective effects against diabetic cardiomyopathy its possible mechanism. A rat model diabetes established using streptozotocin (DCM) evaluated. results demonstrated that significantly reversed DCM-induced changes body weight, heart rate,...
In our study, we determined the pattern of expression and biological roles microRNA-20a (miR-20a) in diabetic kidney disease (DKD). The difference miR-20a proinflammatory genes (TNF-α, IL-6, IL-1β) was measured across control, normal glucose (NG), high (HG) groups. Co-transfection mimic CXCL8 silence used to assess miR-20a/CXCL8 axis HG-induced HK-2 cell injury involved DKD. HG group significantly decreased, a marked augmentation inflammatory factor gene cells induced by HG. over-expression...
We treated a patient who was hyperthyroid due to Graves' disease and strongly resistant methimazole (MMI): in spite of good compliance, she needed 150mg MMI daily control her hyperthyroidism. To elucidate the reasons resistance MMI, serum intrathyroidal concentrations were determined by high pressure liquid chromatography (HPLC). After taking 30mg dose had similar concentration-time curve that normal subject: drug malabsorption rapid metabolism not evident when studied after surgical...
On the basis of scaffold hopping, a novel series 2-alkyl-1-arylsulfonylprolinamides was discovered as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) inhibitors. A representative compound 4ek, obtained through SAR and structure optimization studies, demonstrates excellent in vitro potency against 11β-HSD-1 dose-dependent vivo inhibition prednisone/prednisolone transformation biomarker study mice.
Background . Chronic overnutrition leads to cardiac dysfunction and insulin (INS) resistance. Dipeptidyl peptidase-4 (DPP-4) improves glucose metabolism sensitivity in both human animal models. In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved the protection of function β -cell using an obesity female mouse model. Methods Six-week-old C57BL6/J mice were fed a high fat fructose Western diet with SIT for 12 weeks. Cardiac was examined by echocardiography. Body...
Background: To reveal the alterations of tRNA-derived small RNA (tsRNA) expression profiles induced by hyperbaric oxygen (HBO) treatment in diabetic foot ulcers (DFUs) and investigate new therapeutic targets. Materials & methods: tsRNA sequencing was employed normal skin tissue, DFUs, after HBO groups. A quantitative real-time PCR used to validate results their targets levels. Bioinformatics analysis performed functions DFUs. Results: total 22 tsRNAs were differentially expressed three Three...
Measuring insulin-like growth factor-1 (IGF-1) is useful for assessing and managing growth-related disorders, such as acromegaly hormone deficiency. High-resolution liquid chromatography–mass spectrometry (LC–MS) used measuring IGF-1 due to its molecular specificity, quantitative performance, well-characterized reference materials, detailed age/sex-specific intervals. However, polymorphisms in the IGF1 gene may cause mass shifts polypeptide, which can impede quantitation errors clinical...