A5100700891- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Cell death mechanisms and regulation
- Dietary Effects on Health
- Diabetes Management and Education
- Pain Mechanisms and Treatments
- Bone Metabolism and Diseases
- Calpain Protease Function and Regulation
- Ion channel regulation and function
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Nicotinic Acetylcholine Receptors Study
- Cannabis and Cannabinoid Research
- Heat shock proteins research
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Wound Healing and Treatments
- Phagocytosis and Immune Regulation
- Sleep and Wakefulness Research
- Pressure Ulcer Prevention and Management
- Retinal Development and Disorders
Guiyang College of Traditional Chinese Medicine
2024
Guizhou University
2024
Zunyi Medical University
2024
Soochow University
2007-2023
Shanxi Agricultural University
2022-2023
Liaocheng People's Hospital
2023
Chengdu University of Traditional Chinese Medicine
2021-2022
Qingdao University
2018
Affiliated Hospital of Jining Medical University
2018
China Medical University
2018
Abstract Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are critical regulators of programmed necrosis or necroptosis. However, the role RIPK1/RIPK3 signaling pathway in myocardial fibrosis related diabetic cardiomyopathy is still unclear. We hypothesized that activation mediated by impairing autophagic flux. To this end, we established vitro vivo models type 2 diabetes mellitus with high glucose fat (HGF) medium diet respectively. HGF induced fibrosis, impaired cardiac...
The roles of cathepsins in the ischemic astrocytic injury remain unclear. Here, we test hypothesis that activation cathepsin B and L contributes to astrocyte via tBid‐mitochondrial apoptotic signaling pathways. In rat models pMCAO, CA‐074Me or Clik148, a selective inhibitor L, reduced infarct volume, improved neurological deficits increased MAP 2 GFAP levels. OGD‐induced injury, Clik148 decreased LDH leakage cortex astrocytes reversed pMCAO increase active at 3 h 6 h, tBid, reduction...
<b><i>Aim:</i></b> It has been reported that necrostatin-1 (Nec-1) is a specific necroptosis inhibitor could attenuate programmed cell death induced by myocardial ischemia/reperfusion (I/R) injury. This study aimed to observe the effect and mechanism of novel Nec-1 analog (Z)-5-(3,5-dimethoxybenzyl)-2-imine-1-methylimidazolin-4-1 (DIMO) on I/R <b><i>Methods:</i></b> Male SD rats underwent injury with or without different doses DIMO (1, 2, 4...
Abstract Receptor-interacting protein kinase 1 (RIPK1) contributes to necroptosis. Our previous study showed that pharmacological or genetic inhibition of RIPK1 protects against ischemic stroke-induced astrocyte injury. In this study, we investigated the molecular mechanisms underlying RIPK1-mediated injury in vitro and vivo. Primary cultured astrocytes were transfected with lentiviruses then subjected oxygen glucose deprivation (OGD). a rat model permanent middle cerebral artery occlusion...
Background . Chronic overnutrition leads to cardiac dysfunction and insulin (INS) resistance. Dipeptidyl peptidase-4 (DPP-4) improves glucose metabolism sensitivity in both human animal models. In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved the protection of function β -cell using an obesity female mouse model. Methods Six-week-old C57BL6/J mice were fed a high fat fructose Western diet with SIT for 12 weeks. Cardiac was examined by echocardiography. Body...
Epithelial ovarian cancer (EOC) affects almost 25,000 women annually and is the fifth most common malignancy in North America. A combination of surgery cytotoxic chemotherapy may produce a favorable clinical response. The platinum-paclitaxel regimen gold-standard for advanced cancer, carboplatin one agents this therapy. However, majority patients eventually experience relapse due to development platinum resistance. FUSE binding protein 1 (FBP1) has been identified as an anti-apoptotic...
Abstract Background The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Depression a significant complication T2DM, leading to poor management T2DM. Thus, early detection and treatment depression patients with T2DM are essential effective. Therefore, we plan conduct systematic review meta-analysis evaluate the Chinese explore potential risk factors Methods We will search literatures recorded MEDLINE, EMBASE, Cochrane Library, Biomedical Literature Database (CBM), China...
This study used a novel combination of in vivo and vitro experiments to show that Braintone had neuroprotective effects clarified the molecular mechanisms underlying its efficacy. The Chinese herbal extract is composed Radix Rhodiolase Essence, Notoginseng Folium Ginkgo Essence Rhizoma Chuanxiong. In showed cerebral infarction volume was reduced, hemispheric water content decreased, neurological deficits were alleviated rat model permanent middle artery occlusion after administration 87.5,...
Objective: The incidence of coronary heart disease is rapidly rising in China. relationship serum homocysteine (Hcy) and blood lipid levels with Coronary Heart Disease (CHD) still controversy. This study analysed the Hcy level different types CHD. Patients Methods: A total 100 cases CHD patients healthy volunteers were selected. Serum Hcy, Triglyceride (TG), High Density Lipoprotein (HDL), Low (LDL) measured. compared clinical types, vascular lesions, stenosis by chi-square test. sensitivity...