A5045490892- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Osteoarthritis Treatment and Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Biological Activity of Diterpenoids and Biflavonoids
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- DNA Repair Mechanisms
- Kruppel-like factors research
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Tendon Structure and Treatment
- Protease and Inhibitor Mechanisms
- Inflammatory mediators and NSAID effects
- Flavonoids in Medical Research
- Pluripotent Stem Cells Research
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
- Connective Tissue Growth Factor Research
Jinan University
2013-2025
Guangzhou Medical University
2017
Abstract Articular cartilage injury or defect is a common disease and mainly characterized by degradation because of chondrocyte inflammation. By now, there are no effective drugs methods to protect articular from degradation. Icariin (ICA) typical flavonoid compound extracted Epimedii Folium with anti-inflammatory bone-protective effects. Our previous studies demonstrate that ICA up-regulates HIF-1α expression glycolysis in chondrocytes maintains phenotype. As another member HIFs family,...
Phosphoglycerate mutase 1 (PGAM1) has been identified as a key player in the progression and metastasis of various human cancer types, including breast (BC); however, its precise oncogenic mechanism remains unclear. The present study aimed to investigate mechanisms PGAM1 establish potential therapeutic target. Comprehensive analyses from Tumor Immune Estimation Resource 2.0 Cancer Genome Atlas databases revealed significant upregulation BC, correlating with poor clinical outcomes....
Osteosarcoma, a malignant bone tumor, faces significant treatment challenges. Enhancer of zeste homolog 2 (EZH2) shows aberrant expression in various tumors including osteosarcoma, which is identified as potential therapeutic target. The anti-cancer efficacy EZH2 inhibitor GSK126 has attracted attention, yet its impact on osteosarcoma cells was not fully understood. study investigated the effects cells, particularly apoptosis, autophagy, and cell motility. Our findings revealed that induced...
Bone-tendon junction (BTJ) is a unique structure connecting tendon and bone through fibrocartilage zone. Owing to its structure, the regeneration of BTJ remains challenge. Here, we study fibrochondrogenic differentiation human tendon-derived stem/progenitor cells (TSPCs) both in vitro vivo.TSPCs were isolated from patellar tissues investigated for their multidifferentiation potential. TSPCs cultured chondrogenic medium with transforming growth factor beta 3 (TGF-β3) BMP-2 and examined...
Osteosarcoma is the primary cancer of leaf tissue and regarded as a differentiation disease caused by genetic epigenetic changes which interrupt osteoblast from mesenchymal stem cells. Because its high malignancy degree rapid development, morbidity mortality are high. The enhancer zeste homolog 2 (EZH2) catalytic subunit polycomb repressive complex (PRC2) has been demonstrated to be involved in variety biological processes, such cell proliferation program death. EZH2 impairs gene expression...
Enhancer of zeste homolog 2 (EZH2) is an important member the epigenetic regulatory factor polycomb group proteins (PcG) and abnormally expressed in a wide variety tumors, including osteosarcoma. Scientists consider EZH2 as attractive target for treatment osteosarcoma have found many potential EZH inhibitors, such GlaxoSmithKline 343 (GSK343). It has been reported that GSK343 can be used inhibitor different types cancer. This study demonstrated not only induced apoptosis by increasing...
Ovarian cancer is the seventh most common and second cause of cancer-associated mortality among gynecological malignancies worldwide. The combination antimitotic agents, such as taxanes, DNA-damaging platinum compounds, standard treatment for ovarian cancer. However, due to chemoresistance, development novel therapeutic strategies remains critical. Amentoflavone (AMF) a biflavonoid derived from extracts Selaginella tamariscina, which has been used Chinese herb thousands years. A previous...
Breast cancer is the most common malignant tumor affecting women worldwide and divided into following subtypes: Luminal A, B, HER‑2 overexpression triple‑negative breast (TNBC). TNBC accounts for approximately 15‑20% of all cases. Due to characteristics low differentiation, likelyhood recurrence metastasis, strong invasiveness lack hormone receptors human epidermal growth factor receptor 2 (HER2), patients with cannot benefit from endocrine therapy or other available targeted agents....
Chromodomain helicase DNA-binding protein 1-like gene (CHD1L) was initially isolated as a candidate oncogene in hepatocellular carcinoma, and it has been associated with many malignancies. Knockdown of Chd1l zygote-stage mouse embryos resulted developmental arrest, suggesting that is required for early development. However, the exact role CHD1L development, especially humans, not reported. In this study, we found overexpression human embryonic cells (hESCs) upregulated expression ectoderm...
Epithelial ovarian cancer (EOC) is the fifth most common malignancy in women, with a 5-year mortality of >70% North America. As symptoms are often not observed until has spread extensively, few women diagnosed at an early stage disease. Large-scale gene expression analyses have identified molecular subtypes within high-grade variable survival rates and drug resistance. The understanding expression, mechanisms underlying processes resistances facilitated development targeted therapies....
Worldwide, ovarian cancer (OC) is the seventh common and second most cause of death in women. Due to high rates relapse, there an urgent need for identification new targets OC treatment. The far-upstream element binding protein 1 (FBP1) enhancer zeste homolog 2 (EZH2) are emerging proto-oncogenes that regulate cell proliferation metastasis. In present study, Oncomine data analysis demonstrated FBP1 was closely associated with development OC, Cancer Genome Atlas (TCGA) indicated a positive...
The chemokine (C-X-C motif) ligand (CXCL) family in tumor tissue is closely related to growth, metastasis, and survival. However, the differential expression profile prognostic value of CXCLs ovarian cancer (OC) have not been elucidated. Therefore, we studied levels mutations OC patient TCGA various public databases. differences tissues normal were compared through Gene Expression Profiling Interactive Analysis (GEPIA) database. effect on prognosis was analyzed using Kaplan-Meier curves...
Epithelial ovarian cancer (EOC) affects almost 25,000 women annually and is the fifth most common malignancy in North America. A combination of surgery cytotoxic chemotherapy may produce a favorable clinical response. The platinum-paclitaxel regimen gold-standard for advanced cancer, carboplatin one agents this therapy. However, majority patients eventually experience relapse due to development platinum resistance. FUSE binding protein 1 (FBP1) has been identified as an anti-apoptotic...
Fibrocartilage transition zone (FC) is difficult to regenerate after surgical re-attachment of tendon bone. Here, we investigated whether type II collagen-sponges (CII-sponges) facilitated stem/progenitor cells (TSPCs) adopt chondrogenic phenotypes and further observed if this material could increase the FC areas in bone-tendon junction (BTJ) injury model. CII-sponges were made as previously described. The appearance pore structure photographed by camera microscopies. viability,...
The pathological mechanism of vascular cognitive impairment (VCI) involves ischemic lesions in the hippocampus. Prostaglandin E1 (PGE1) serves roles promotion endothelial growth factor (VEGF) expression, angiogenesis and enhances blood flow to regions. However, effect PGE1 on function VCI rats underlying are unknown. In current study, learning memory treated by lipo‑PGE1 injection was assessed through Morris Water Maze test. Furthermore, histological alterations, vessel numbers hippocampal...