A5100740301- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Blood groups and transfusion
- Genetic Mapping and Diversity in Plants and Animals
- Urban Transport and Accessibility
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA and protein synthesis mechanisms
- Pediatric health and respiratory diseases
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- Hormonal Regulation and Hypertension
- RNA Research and Splicing
- Chemical Reactions and Mechanisms
- Transportation Planning and Optimization
- Human Mobility and Location-Based Analysis
- Lung Cancer Treatments and Mutations
- Eicosanoids and Hypertension Pharmacology
- Pulmonary Hypertension Research and Treatments
- Frailty in Older Adults
- Advanced Fluorescence Microscopy Techniques
- Marine Sponges and Natural Products
- MicroRNA in disease regulation
Xinjiang Institute of Engineering
2024
Blood Center of Zhejiang Province
2021-2024
Wuhan Technical College of Communications
2024
Tianjin Medical University
2021-2023
Dalian University of Technology
2023
Wuhan University
2014-2023
Gansu University of Traditional Chinese Medicine
2023
Shanxi Medical University
2008-2022
First Hospital of Shanxi Medical University
2008-2022
Qingdao University
2022
Abstract Background Time-restricted feeding is an emerging dietary intervention that becoming increasingly popular. There are, however, no randomised clinical trials of time-restricted in overweight patients with type 2 diabetes. Here, we explored the effects on glycaemic regulation and weight changes diabetes over 12 weeks. Methods Overweight adults (n = 120) were 1:1 to two diet groups: 60) or control 60). Sixty participated a 10-h restricted treatment program (ad libitum from 8:00 18:00...
The molecular pathogenesis of focal/diffuse proliferative lupus glomerulonephritis was studied by cDNA microarray analysis gene expression in glomeruli from clinical biopsies. Transcriptional phenotyping isolated laser-capture microscopy revealed considerable kidney-to-kidney heterogeneity increased transcript expression, resulting four main clusters that identified the presence B cells, several myelomonocytic lineages, fibroblast and epithelial cell proliferation, matrix alterations, type I...
DNA microarrays provide a global view of the physiological state cell by parallel analysis expression levels all genes in an organism. The effects four bactericidal agents on pattern <i>Escherichia coli</i> MG1655 were assessed. Compounds chosen basis their different mechanisms action and included inhibitors replication recombination, translation, transcription wall biosynthesis. addition rifampin resulted increased target, <i>rpoB,</i> as well several involved...
The preparation of a nickel sulfide/graphene nanocomposite electrode <italic>via</italic> hydrothermal process.
A binder-free electrode is prepared by directly depositing electrochemically reduced graphene oxide (ERGO) on the metal current collector. Fourier transform infrared spectroscopy and Raman spectrum have been used to demonstrate effective reduction of electrode, porous structure ERGO film was further characterized scanning electron microscopy. The electrochemical properties were investigated cyclic voltammetry, galvanostatic charge–discharge impedance (EIS). Electrochemical measurements...
The outer membrane (OM) of Gram-negative bacteria is a permeability barrier that impedes the entry external insults, such as antibiotics and bile salts. This function depends critically on asymmetric lipid distribution across bilayer, with lipopolysaccharides (LPS) facing outside phospholipids (PLs) inside. In Escherichia coli, OmpC-Mla system believed to maintain OM asymmetry by removing surface exposed PLs shuttling them back inner (IM). How proteins in pathway interact mediate PL...
Abstract Motivation: Affymetrix GeneChip® arrays are currently the most widely used microarray technology. Many summarization methods have been developed to provide gene expression levels from probe-level data. Most of popular do not a measure uncertainty for level each gene. The use probabilistic models can overcome this limitation. A full hierarchical Bayesian approach requires computationally intensive MCMC that impractical large datasets. An alternative efficient model, mgMOS, uses Gamma...
Abstract Motivation: Finding differentially expressed genes is a fundamental objective of microarray experiment. Numerous methods have been proposed to perform this task. Existing are based on point estimates gene expression level obtained from each This approach discards potentially useful information about measurement error that can be an appropriate probe-level analysis. Probabilistic models used measure and also provide uncertainty in measurement. provides which help the identification...
A fundamental goal in the study of infections is to understand dynamic interplay between host and pathogen; however, direct vivo interrogation this disease process via transcriptional profiling has been lacking. Here we describe development application novel bacterial RNA amplification technology simultaneously identify key elements both pathogen responses a murine infection model. On side, found induction an unusual pattern stress response genes, host-induced metal ion limitation, failure...
The first asymmetric synthesis of 1,2-dioxolane-3-acetic acids is reported. Key features include the stereoselective opening enantiomerically enriched oxetanes by hydrogen peroxide, conversion resulting 4-hydroperoxy-2-alkanols to 3-alkoxy-1,2-dioxolanes, and Lewis acid mediated homologation latter with a thioester silyl ketene acetal. approach modeled on 3,5-dimethyl-5-hexadecyl-1,2-dioxolane-3-acetic (1a), an unnamed natural product, optimized strategy applied four stereoisomers plakinic A...
Researchers have shown that long noncoding RNAs are closely associated with the pathogenesis of laryngeal squamous cell carcinoma (LSCC). However, role RNA taurine-upregulated gene 1 (TUG1) in LSCC remains unclear, although it is recognized as an oncogenic regulator for several types carcinoma.qRT-PCR was performed to measure expression TUG1 tissues and lines. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) used effect on proliferation. Transwell assay flow cytometry...
MicroRNAs (miRNAs) have been demonstrated to be critical in regulating tumor development and progression. The present study investigated the expression of miR‑588 using reverse transcription‑quantitative polymerase chain reaction analysis 85 cases lung squamous cell carcinoma (SCC), observed correlation between with clinical pathologic features. results indicated that was predominantly lower samples, compared non‑tumorous negatively associated stages lymph node invasion. also examined...
The present study aimed to investigate the expression of long non-coding RNA (lncRNA) cyclin dependent kinase inhibitor-2B-antisense 1 CDKN2B-AS1 in patients with peripheral blood idiopathic pulmonary fibrosis (IPF). A total 24 IPF and healthy controls were included study, four selected randomly extract RNA. There no other diseases such as hypertension diabetes two groups. from was extracted by high-throughput sequencing bioinformatics analysis performed. Based on differentially expressed...
Predicting in vivo protein–DNA binding sites is a challenging but pressing task variety of fields like drug design and development. Most promoters contain number transcription factor (TF) sites, only small minority has been identified by biochemical experiments that are time-consuming laborious. To tackle this challenge, many computational methods have proposed to predict TF from DNA sequence. Although previous achieved remarkable performance the prediction interactions, there still...
Elongation of the Drosophila embryonic hindgut epithelium occurs by a process oriented cell rearrangement requiring genes drumstick (drm) and lines (lin). The elongating becomes subdivided into domains – small intestine, large intestine rectum each characterized specific pattern gene expression dependent upon normal drm lin function. We show that encodes an 81 amino acid (10 kDa) zinc finger protein is member Odd-skipped family. localized to developing midgut-hindgut junction required...
To evaluate the prevalence of vitamin B12 deficiency in Chinese patients with type 2 diabetes mellitus receiving metformin treatment and to investigate effects daily dose duration on peripheral neuropathy (PN). In this multicenter cross-sectional study, 1027 who had been taking ≥1000 mg/day for ≥1 year were enrolled using proportionate stratified random sampling based duration. Primary measures included (<148 pmol/L), borderline (148 pmol/L-211 PN. The deficiency, PN 2.15%, 13.66%, 11.59%,...
A series of CdMoO4/CdS hybrid composites were synthesized via a one-step hydrothermal method. The products characterized by X-ray diffraction, scanning electron microscopy, photoelectron spectroscopy, Raman and UV-vis diffuse reflection spectroscopy. photocatalytic activities the materials compared with CdMoO4 microspheres dendritic CdS nanostructures evaluated rhodamine B (RhB) decomposition under sunlight irradiation. results revealed that as-prepared showed superior for degradation RhB...