A5079785653- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Immunotherapy and Immune Responses
- biodegradable polymer synthesis and properties
- Phagocytosis and Immune Regulation
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Polymer Surface Interaction Studies
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Pickering emulsions and particle stabilization
- Synthetic Organic Chemistry Methods
- Extracellular vesicles in disease
- Microplastics and Plastic Pollution
- Click Chemistry and Applications
- Hydrogels: synthesis, properties, applications
- CAR-T cell therapy research
- Tryptophan and brain disorders
- Virus-based gene therapy research
South China University of Technology
2017-2025
Guangzhou Medical University
2018-2022
Guangzhou First People's Hospital
2018-2022
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2018-2022
Northwest A&F University
2022
Indiana University School of Medicine
2020
Third Xiangya Hospital
2020
Central South University
2020
National Research Center for Rehabilitation Technical Aids
2017-2018
University of Science and Technology of China
2006-2016
Efficient delivery of therapeutics into tumor cells to increase the intracellular drug concentration is a major challenge for cancer therapy due resistance and inefficient cellular uptake. Herein, we have designed tailor-made dual pH-sensitive polymer-drug conjugate nanoparticulate system overcome challenges. The nanoparticle capable reversing its surface charge from negative positive at extracellular pH (∼6.8) facilitate cell internalization. Subsequently, significantly increased acidity in...
A principal goal of cancer nanomedicine is to deliver therapeutics effectively cells within solid tumors. However, there are a series biological barriers that impede from reaching target cells. Here, we report stimuli-responsive clustered nanoparticle systematically overcome these multiple by sequentially responding the endogenous attributes tumor microenvironment. The smart polymeric (iCluster) has an initial size ∼100 nm, which favorable for long blood circulation and high propensity...
The currently low delivery efficiency and limited tumor penetration of nanoparticles remain two major challenges cancer nanomedicine. Here, we report a class pH-responsive nanoparticle superstructures with ultrasensitive size switching in the acidic microenvironment for improved effective vivo drug delivery. were constructed from amphiphilic polymer directed assembly platinum-prodrug conjugated polyamidoamine (PAMAM) dendrimers, which contains ionizable tertiary amine groups rapid...
A positive (or negative) chameleon: nanogel that is negatively charged at physiological pH values and activated to be positively tumor extracellular was internalized efficiently by cells both in vitro vivo (see illustration). Intracellular drug release also enhanced, probably as a result of decrease the interaction between its protonated state.
Two faced nanoparticles: A zwitterionic polymer-based nanoparticle with response to tumor acidity is developed for enhanced drug delivery tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into sites, in the acidic extracellular environment (pHe), activated become positively therefore efficiently taken up by cells, leading therapeutic effects cancer treatment. Detailed facts of importance specialist readers published...
Combination of two or more therapeutic strategies with different mechanisms can cooperatively prohibit cancer development. chemotherapy and small interfering RNA (siRNA)-based therapy represents an example this approach. Hypothesizing that the chemotherapeutic drug siRNA should be simultaneously delivered to same tumoral cell exert their synergistic effect, development delivery systems efficiently encapsulate drugs successfully deliver payloads targeted sites via systemic administration has...
An efficient and safe delivery system for small interfering RNA (siRNA) is required clinical application of therapeutics. Polyethyleneimine (PEI)-capped gold nanoparticles (AuNPs) are successfully manufactured using PEI as the reductant stabilizer, which bind siRNA at an appropriate weight ratio by electrostatic interaction result in well-dispersed with uniform structure narrow size distribution. With binding, PEI-capped AuNPs induce more significant enhanced reduction targeted green...
Drug delivery systems for cancer therapy usually need to be sterically stabilized by a poly(ethylene glycol) (PEG) layer during blood circulation minimize nonspecific interactions with serum components. However, PEGylation significantly reduces cellular uptake of the after they accumulate at tumor site, which markedly impairs in vivo antitumor efficiency. Here, we develop ternary small interfering RNA (siRNA) system acidity-activated sheddable PEG overcome challenge. The nanoparticle is...
Chemoimmunotherapy, which combines chemotherapeutics with immune-modulating agents, represents an appealing approach for improving cancer therapy. To optimize its therapeutic efficacy, differentially delivering multiple drugs to target cells is desirable. Here we developed immunostimulatory nanocarrier (denoted as BLZ-945SCNs/Pt) that could spatially tumor-associated macrophages (TAMs) and tumor chemoimmunotherapy. BLZ-945SCNs/Pt undergo supersensitive structure collapse in the prevascular...
Enabling macrophages to phagocytose tumor cells holds great potential for cancer therapy but suffers from tremendous challenges because the upregulate antiphagocytosis molecules (such as CD47) on their surface. The blockade of CD47 alone is insufficient stimulate cell phagocytosis in solid tumors due lack "eat me" signals. Herein, a degradable mesoporous silica nanoparticle (MSN) reported simultaneously deliver anti-CD47 antibodies (aCD47) and doxorubicin (DOX) chemo-immunotherapy....
Aiming at development of a micellar nanoparticle system for intracellular drug release triggered by glutathione in tumor cells, disulfide-linked biodegradable diblock copolymer poly(ε-caprolactone) and poly(ethyl ethylene phosphate) was synthesized. It formed biocompatible micelles loaded with doxorubicin aqueous solution but detached the shell material under stimulus, resulting rapid destruction structure. These glutathione-sensitive also rapidly released molecules intracellularly led to...
Polyphosphoesters (PPEs) with repeating phosphoester bonds in the backbone are structurally versatile, biocompatible, and biodegradable through hydrolysis as well enzymatic digestion under physiological conditions. They appealing for biological applications because of their potential functionality, biocompatibility, similarity to biomacromolecules such nucleic acids. The expanding scope PPEs materials science, especially biomaterials, is described this review. We mainly focus on controlled...
Abstract Successful bench‐to‐bedside translation of nanomedicine relies heavily on the development nanocarriers with superior therapeutic efficacy and high biocompatibility. However, optimal strategy for improving one aspect often conflicts other. Herein, we report a tactic designing tumor‐pH‐labile linkage‐bridged copolymers clinically validated poly( d,l ‐lactide) poly(ethylene glycol) (PEG‐ Dlink m ‐PDLLA) safe effective drug delivery. Upon arriving at tumor site, PEG‐ ‐PDLLA...
Brush polymers PHEMA-g-(PCL-b-PEG) with poly(2-hydroxyethyl methacrylate) (PHEMA) as the backbone and poly(epsilon-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) block copolymers side chains were synthesized evaluated drug delivery vehicles. Two brush synthesized, their structures confirmed by gel permeation chromatography analyses (1)H NMR measurements. The self-assembled into micelles in aqueous solution, critical micellization concentrations of 2-fold lower than that linear diblock...
Ein positives (oder negatives) Chamäleon: bei physiologischen pH-Werten negativ und den im extrazellulären Bereich von Tumoren positiv geladenes Nanogel wurde durch die Tumorzellen in vitro wie vivo effizient internalisiert (siehe Bild). Auch Wirkstoff-Freisetzung der Zelle war verstärkt, vielleicht als Folge einer geringeren Wechselwirkung zwischen dem Wirkstoff protonierten Nanogel.
Precisely controlling the interaction of nanoparticles with biological systems (nanobio interactions) from injection site to targets shows great potential for biomedical applications. Inspired by ability alter their physicochemical properties according different stimuli, we explored tumor acidity and near-infrared (NIR) light activated transformable nanoparticle DATAT-NPIR&DOX. This consists a acidity-activated TAT [the lysine residues' amines was modified 2,3-dimethylmaleic anhydride (DA)],...
Positively charged nanoparticles showed a favorable distribution in the small intestine, and significantly improved oral bioavailability.