A5021091013- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Gastric Cancer Management and Outcomes
- Nanoplatforms for cancer theranostics
- Colorectal Cancer Surgical Treatments
- Immune cells in cancer
- Stability and Control of Uncertain Systems
- Metaheuristic Optimization Algorithms Research
- Ferroelectric and Negative Capacitance Devices
- Aquatic Ecosystems and Phytoplankton Dynamics
- Advanced Multi-Objective Optimization Algorithms
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Measurement and Detection Methods
- MRI in cancer diagnosis
- Advanced Memory and Neural Computing
- Crystallization and Solubility Studies
- Microbial Community Ecology and Physiology
- X-ray Diffraction in Crystallography
- Multimodal Machine Learning Applications
- Wastewater Treatment and Nitrogen Removal
- Domain Adaptation and Few-Shot Learning
Zhengzhou University of Light Industry
2023-2025
University of Pennsylvania
2024
Xi'an University of Architecture and Technology
2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
University of Science and Technology of China
2015-2023
South China University of Technology
2021-2023
Third Affiliated Hospital of Harbin Medical University
2021-2023
Harbin Medical University
2021-2023
Taiyuan University of Technology
2022
Chemoimmunotherapy, which combines chemotherapeutics with immune-modulating agents, represents an appealing approach for improving cancer therapy. To optimize its therapeutic efficacy, differentially delivering multiple drugs to target cells is desirable. Here we developed immunostimulatory nanocarrier (denoted as BLZ-945SCNs/Pt) that could spatially tumor-associated macrophages (TAMs) and tumor chemoimmunotherapy. BLZ-945SCNs/Pt undergo supersensitive structure collapse in the prevascular...
The NLRP3 inflammasome is a well-studied target for the treatment of multiple inflammatory diseases, but how to promote current therapeutics remains large challenge. CRISPR/Cas9, as gene editing tool, allows direct ablation at genomic level. In this study, we screen an optimized cationic lipid-assisted nanoparticle (CLAN) deliver Cas9 mRNA (mCas9) and guide RNA (gRNA) into macrophages. By using CLAN encapsulating mCas9 gRNA-targeting (gNLRP3) (CLANmCas9/gNLRP3), disrupt macrophages,...
Abstract Modulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T tumor chimeric antigen receptor- or bispecific cell-engaging are two typical cancer immunotherapy approaches. We speculated that immobilizing types mAbs against on a single nanoparticle could integrate functions these approaches, as engineered formulation (immunomodulating nano-adaptor, imNA) potentially associate with both bridge them together like an ‘adaptor’ while...
Abstract HfO 2 ‐based memristors that remembers the history of current has passed through them have attracted great interest for use as artificial synapses in neuromorphic systems. However, low resistance contrast exhibited by seriously decreases their recognition accuracy. By inserting a nm BiFeO 3 layer large memory window 10 4 and remarkable pulse endurance 8 cycles are achieved. Multilevel storage capability is also demonstrated controlling stop voltages RESET process. The...
Tumor metastasis remains the primary cause of treatment failure in cancer patients, and high-sensitivity preoperative intraoperative detection occult micrometastases continues to pose a notorious challenge. Therefore, we have designed an situ albumin-hitchhiking near-infrared window II (NIR-II) fluorescence probe, IR1080, for precise subsequent image-guided surgery. IR1080 rapidly covalently conjugates with albumin plasma, resulting stronger brightness upon binding. Moreover,...
Abstract The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). How simultaneously attenuates bacterial growth suppresses a variety infections in plants animals is not known. Here we show, using X-ray crystal structures functional analyses, that single molecule occupies four distinct subsites within catalytic domain human ThrRSs. These...
Accumulating evidence has confirmed that malignant tumors have a complex microenvironment, which consists of heterogeneous collection tumor cells and other cell subsets (including the full gamut immune cells). Tumor-associated macrophages (TAMs), derived from circulating Ly6Chi monocytes, constitute most substantial fraction tumor-infiltrating in nearly all cancer types contribute to progression, vascularization, metastasis, immunosuppression, therapeutic resistance. Interrupting monocyte...
Excessive infiltration of activated neutrophils is regarded as a predominant cause tissue injury in neutrophilic inflammation. Although programmed cell death like apoptosis maintains the homeostasis neutrophils, this process disrupted by an abnormal inflammatory response. Unlike endogenous calreticulin exposed during apoptosis, exogenous acts "aged" signal and initiates premature macrophage-mediated removal (PrCR), which independent apoptosis. Here, we report nano-mediated strategy to...
Proliferative hepatocellular carcinomas (HCCs) is a class of aggressive tumors with poor prognosis. We aimed to construct computed tomography (CT)-based radiomics nomogram predict proliferative HCC, stratify clinical outcomes and explore the tumor microenvironment.
Few-shot segmentation focuses on the generalization of models to segment unseen object instances with limited training samples. Although tremendous improvements have been achieved, existing methods are still constrained by two factors. (1) The information interaction between query and support images is not adequate, leaving intra-class gap. (2) categories at inference stages no overlap, inter-class Thus, we propose a framework, BriNet, bridge these gaps. First, more interactions encouraged...
Crosstalk between dendritic cells and T plays a crucial role in modulating immune responses natural pathological conditions. DC-T cell crosstalk is achieved through contact-dependent (i.e., immunological synapse) contact-independent mechanisms cytokines). Activated DCs upregulate co-stimulatory signals secrete proinflammatory cytokines to orchestrate activation differentiation. Conversely, activated helper “license” towards maturation, while regulatory (Tregs) silence elicit tolerogenic...
The synthesis of chromeno[2,3-b]indole from simple starting materials remains a demanding process. Herein, 2-bromoindole undergoes nucleophilic attack salicylaldehyde, followed by intramolecular insertion an aldehyde group and aromatization to generate the desired chromeno[2,3-b]indoles. Moreover, various functional groups were tolerated gram-scale product could be achieved under optimized condition.
Ce/TiO2–SiO2 catalysts with different Ti/Si molar ratios are prepared by the incipient impregnation method and their NH3-SCR activities evaluated at 100–500°C on a fixed reactor. The (3/1) catalyst, modified non-thermal plasma (NTP) treatment then activated thermal 500°C for 4 h, exhibits best performance. Comprehensive deNOx performance of catalyst is evidently improved its efficiency reaches up to 99.21% 350°C. NO conversion treated doped K remains about 90.23% 300°C also shows activity...