A5100340386- Aquaculture disease management and microbiota
- Immunotherapy and Immune Responses
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- Advanced Software Engineering Methodologies
- Service-Oriented Architecture and Web Services
- CAR-T cell therapy research
- Business Process Modeling and Analysis
- Cytomegalovirus and herpesvirus research
- Anomaly Detection Techniques and Applications
- Phagocytosis and Immune Regulation
- T-cell and B-cell Immunology
- Nuclear Receptors and Signaling
- Opportunistic and Delay-Tolerant Networks
- Herpesvirus Infections and Treatments
- Porphyrin and Phthalocyanine Chemistry
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Dental Health and Care Utilization
- Mobile Ad Hoc Networks
- Insect symbiosis and bacterial influences
- Oral microbiology and periodontitis research
- Age of Information Optimization
- Macrophage Migration Inhibitory Factor
- Tryptophan and brain disorders
Jimei University
2023
University of Science and Technology of China
2010-2021
South China University of Technology
2021
Xiamen University
2014-2020
Hefei National Center for Physical Sciences at Nanoscale
2019
Hefei University
2019
Huazhong Agricultural University
2016
Kyushu University
2016
Capital Medical University
2015
City University of Hong Kong
2010-2012
Certain chemotherapeutics (e.g., oxaliplatin, OXA) can evoke effective antitumor immunity responses by inducing immunogenic cell death (ICD). Unfortunately, tumors always develop multiple immunosuppressive mechanisms, such as the upregulation of factors, to counteract effects chemotherapy. Indoleamine 2,3-dioxygenase-1 (IDO1), a tryptophan catabolic enzyme overexpressed in tumor-draining lymph nodes (TDLNs) and tumor tissues, plays pivotal role generation microenvironment. Reversing...
Abstract Modulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T tumor chimeric antigen receptor- or bispecific cell-engaging are two typical cancer immunotherapy approaches. We speculated that immobilizing types mAbs against on a single nanoparticle could integrate functions these approaches, as engineered formulation (immunomodulating nano-adaptor, imNA) potentially associate with both bridge them together like an ‘adaptor’ while...
Abstract Molt is a critical developmental process in crustaceans. Recent studies have shown that the hepatopancreas an important source of innate immune molecules, yet hepatopancreatic patterns gene expression during molt cycle which may underlie changes mechanism are unknown. In this study, we performed Illumina sequencing for mud crab, Scylla paramamosain (pre-molt stage, post-molt and inter-molt stage). A total 44.55 Gb high-quality reads were obtained from normalized cDNA hepatopancreas....
Although HAD is now rare due to HAART, the milder forms of HAND persist in HIV-infected patients. HIV-induced systemic and localized inflammation considered be one mechanisms HAND. The levels cytokines CSF were associated with neurocognitive impairment HIV infection. However, changes involved cognition plasma have not been shown, their relationships between require addressed. We compared cytokine paired samples from individuals or without impairment. Cytokine concentrations measured by...
Metabolic syndrome is associated with periodontal disease and dental caries; however, little attention has been given to the association between metabolic tooth loss, which endpoint of these two diseases. This study examined this in middle-aged adults over a 5-year period.A retrospective was performed 2107 participants (1718 males 389 females) aged 35-60 years who underwent annual check-ups, evaluate loss components, including obesity, elevated triglycerides, blood pressure, fasting glucose,...
Rheumatoid arthritis (RA) is a systemic autoimmune disease that can cause irreversible joint deformity. There still no cure for RA, and current therapeutics, including methotrexate adalimumab, serious off-target effects immunosuppression, which in turn increases the risk of infection. Bruton's tyrosine kinase (BTK) macrophages B cells has been demonstrated to be promising therapeutic target RA. However, high doses BTK inhibitors are required efficient suppression, limits their clinical use....
Thymus is the crucial site for T cell development and once believed to be immune privileged. Recently, thymus has gained special attention as it commonly targeted by infectious agents which may cause pathogenic tolerance subsequent immunosuppression. We analyzed thymic responses challenge with Salmonella typhimurium (STm) or lipopolysaccharide (LPS) derived from STm in chicks. Newly hatched chicks were injected intraperitoneally 5 × 104 CFU/mL 50 mg/kg LPS. After LPS treatment, maximum...
Delay tolerant networks (DTNs) experience frequent and long lasting network disconnection due to various reasons such as mobility, sleep scheduling, etc. Anycast routing is an important challenging problem in DTNs. In this paper, we study the single-copy message anycast probability-contacted We first define a novel metric MDRA (Maximum Delivery Rate for Anycast) indicate maximum successful probability of routing, then propose algorithm based on metric. Rigorous theoretical analysis shows...
Web services technologies promise to create new business applications by composing existing and publish these as for further composition. The logic of is described abstract processes consisting tasks which specify the required functionality. provision refers assigning concrete perform constituent processes. It describes a promising scenario where are dynamically chosen invoked according their up-to-date functional non-functional capabilities. introduces many challenging problems has...
Macrophage migration inhibitory factor(MIF),which is a cytokine of many biological activities,plays key role in the immunoregulatory system.The MIF levels produced vivo directly influence susceptibility and severity some diseaseg.Polymorphisms exist promoter region that alters its expression.In this review,we discuss MIF,and summarize recent findings describing polymorphisms as well correlation with diseases. Key words: MIF; Promoter; Polymorphism; Disease