A5100760993- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- T-cell and B-cell Immunology
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Cell death mechanisms and regulation
- Cancer-related molecular mechanisms research
- Silk-based biomaterials and applications
Huazhong University of Science and Technology
2016-2025
Shandong First Medical University
2025
Union Hospital
2012-2025
Anhui Medical University
2014-2025
First Affiliated Hospital of Anhui Medical University
2014-2025
Union Hospital
2015-2024
First Affiliated Hospital Zhejiang University
2024
Jining First People's Hospital
2023
Affiliated Hospital of Southwest Medical University
2023
Shanghai Jiao Tong University
2022
The interaction between T cell immunoglobulin- and mucin-domain-containing molecule (Tim-3) expressed on helper 1 (Th1) cells, its ligand, galectin-9, negatively regulates Th1-mediated immune responses. However, it is poorly understood if how the Tim-3/galectin-9 signaling pathway involved in escape patients with hepatocellular carcinoma (HCC). Here we studied expression, function, regulation of hepatitis B virus (HBV)-associated HCC. We detected different levels galectin-9 expression...
Abstract Foxp3+CD4+ regulatory T (Treg) cells inhibit immune responses and temper inflammation. IL-17+CD4+ (Th17) mediate inflammation of autoimmune diseases. A small population IL-17+Foxp3+CD4+ has been observed in peripheral blood healthy human beings. However, the biology remains poorly understood humans. We investigated their phenotype, cytokine profile, generation, pathological relevance patients with ulcerative colitis. that high levels were selectively accumulated colitic...
Infiltration of tumors with effector T cells is positively associated therapeutic efficacy and patient survival. However, the mechanisms underlying T-cell trafficking to tumor microenvironment remain poorly understood in patients colon cancer. The polycomb repressive complex 2 (PRC2) involved cancer progression, but regulation immunity by epigenetic has yet be investigated. In this study, we examined relationship between PRC2 machinery trafficking. We found that components demethylase...
Myocardial infarction (MI), a main cause of heart failure, leads to irreversible cardiomyocytes loss and cardiac function impairment.Current clinical treatments for MI are largely ineffective as they mostly aim alleviate symptoms rather than repairing the injured myocardium.Thus, development more effective therapies is compelling.This study aims investigate whether extracellular vesicles (EVs) carrying specific anti-apoptotic miRNA can be efficiently internalized into myocardium achieve...
Chemodrug resistance is a major reason accounting for tumor recurrence. Given the mechanistic complexity of chemodrug resistance, molecular inhibitors and targeting drugs often fail to eliminate drug-resistant cancer cells, sometimes even promote chemoresistance by activating alternative pathways. Here, exploiting biochemical fragility high-level but dynamically balanced cellular redox homeostasis in we design nanosized copper/catechol-based metal-organic framework (CuHPT) that effectively...
Reciprocal cellular crosstalk within the tumour microenvironment (TME) actively participates in progression. The anterior gradient-2 (AGR2) can be secreted to extracellular compartments and contribute colorectal cancer (CRC) metastasis. We investigated source for AGR2 TME underlying mechanisms mediating AGR2's effects.Tissue microarray, tissues, blood samples tumour-associated neutrophils (TANs) from patients with CRC were isolated phenotypical functional analyses. role of TAN-secreted was...
Activated T cells may express FOXP3. It is thought that FOXP3 not a specific marker to determine regulatory (Treg) in humans. Here, we examined the functional phenotype and cytokine profile of vitro induced FOXP3(+) cells, primary FOXP3(-) patients with ulcerative colitis tumors including colon carcinoma, melanoma, hepatic ovarian pancreatic cancer, renal cell carcinoma. We observed similar levels suppressive capacity blood, tumors, colitic tissues. Compared same microenvironment, these...
The expression and biological role of IL33 in colon cancer is poorly understood. In this study, we show that expressed by vascular endothelial cells tumor the human microenvironment. Administration overexpression murine enhanced cell growth vivo, respectively. stimulated sphere formation prevented chemotherapy-induced apoptosis. Mechanistically, activated core stem genes NANOG, NOTCH3, OCT3/4 via ST2 signaling pathway, induced phosphorylation c-Jun N terminal kinase (JNK) activation binding...
Severe side effects of cancer chemotherapy prompt developing better drug delivery systems. Injectable hydrogels are an effective site-target system. For most injectable hydrogels, once delivered in vivo, some properties including release and degradation, which critical to chemotherapeutic safety, challenging monitor. Developing a system for therapy with vivo real-time noninvasive trackability is highly desired. Although fluorescence dyes used imaging the cytotoxicity limits their...
Human prostate cancer frequently metastasizes to bone marrow. What defines the cellular and molecular predilection for metastasize marrow is not well understood. CD4+CD25+ regulatory T (Treg) cells contribute self-tolerance tumor immune pathology. We now show that functional Treg are increased in microenvironment patients with metastasis, CXCR4/CXCL12 signaling pathway contributes cell trafficking. exhibit active cycling marrow, dendritic express high levels of receptor activator NFκB...
The severe cytotoxicity of cancer chemotherapy drugs limits their clinical applications. Various protein-based nanoparticles with good biocompatibility have been developed for drug delivery in hope reducing drugs' side effects. Sericin, a natural protein from silk, has no immunogenicity and possesses diverse bioactivities that prompted sericin's application studies. However, the potential sericin as multifunctional nanoscale vehicle therapy not fully explored. Here we report successful...
Full-thickness skin injury affects millions of people worldwide each year. It often leads to scar formation and loss appendages even after clinical treatment. The majority wound dressings currently used cannot achieve scarless regeneration with complete recovery such as hair follicles sebaceous glands. Functional these is a great challenge. However, we achieved this goal by the successful development utilization photo-crosslinkable sericin hydrogel (SMH) new type dressing for repairing...
Bone defects affect millions of people worldwide each year, leading to severe disabilities. Biomimetic scaffolds mediated tissue regeneration represents a promising alternative for bone repair. However, the major problem associated with most currently clinical available artificial substitutes (scaffolds) is that they mainly possess filling function but lack osteo-induction abilities. Therefore, development biomaterials property effective highly desired. Methods: We report design and...
Stroke is one of most common causes death and disability. Most neuroprotective agents fail to rescue neurons from cerebral ischemic insults, mainly because targeting downstream cascading events, such as excitotoxicity, oxidative nitrosative stress, inflammation, rather than improving hypoxia that initially occurs. Here, we report a near-infrared light (NIR)-driven nanophotosynthesis biosystem capable generating oxygen absorbing carbon dioxide, thus rescuing ischemia toward treating stroke....
Recently, the combination of immunotherapy with chemotherapy has been recommended as first-line treatment metastatic gastric/gastroesophageal junction (G/GEJ) in clinical guidelines many countries; therapeutic potential this application needs to be further investigated for neoadjuvant therapy advanced G/GEJ cancer patients.We performed a prospective, single-arm, open-label, phase 2 trial PD-1 inhibitor tislelizumab combined S-1 plus oxaliplatin (SOX) patients LAG/GEJ cancer. All underwent...