A5101505007- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Immune cells in cancer
- RNA modifications and cancer
- Advanced Glycation End Products research
- Colorectal and Anal Carcinomas
- Drug-Induced Hepatotoxicity and Protection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Protein Degradation and Inhibitors
- Sepsis Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Fatty Acid Research and Health
- Ferroptosis and cancer prognosis
Union Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Xi’an University of Posts and Telecommunications
2024
Union Hospital
2016-2024
Nantong University
2024
Wuhan Union Hospital
2018-2023
Wuhan University
2021-2022
Takeda (United States)
2021
Millennium Engineering and Integration (United States)
2021
Sun Yat-sen Memorial Hospital
2021
Drugs, viruses, and chemical poisons stimulating live in a short period of time can cause acute liver injury (ALI). ALI further develop into serious diseases such as cirrhosis cancer. Therefore, how to effectively prevent treat has become the focus research. Numerous studies have reported Maresin1 (MaR1) anti-inflammatory effect protective functions on organs. In present study, we used d-galactosamine/lipopolysaccharide (D-GalN/LPS) establish an model, explored mechanism cells death caused...
Cuproptosis, a novel copper-induced cell death pathway, is linked to mitochondrial respiration and mediated by protein lipoylation. The discovery of cuproptosis unfolds new areas investigation, particularly in cancers. present study aimed explore the role colorectal cancer progression. genetic alterations colon were evaluated using database. MTT assays, colony formation, flow cytometry used examine effect elesclomol-Cu 4-Octyl itaconate (4-OI) on oxaliplatin-resistant viability. anti-tumor...
Maresin 1 (MaR 1) was recently reported to have protective properties in several different animal models of acute inflammation by inhibiting inflammatory response. However, its function liver injury is still unknown. To address this question, we induced BALB/c mice with intraperitoneal injection carbon tetrachloride or without treatment MaR 1. Our data showed that attenuated hepatic injury, oxidative stress, and lipid peroxidation tetrachloride, as evidenced increased thiobarbituric acid...
Recently, the combination of immunotherapy with chemotherapy has been recommended as first-line treatment metastatic gastric/gastroesophageal junction (G/GEJ) in clinical guidelines many countries; therapeutic potential this application needs to be further investigated for neoadjuvant therapy advanced G/GEJ cancer patients.We performed a prospective, single-arm, open-label, phase 2 trial PD-1 inhibitor tislelizumab combined S-1 plus oxaliplatin (SOX) patients LAG/GEJ cancer. All underwent...
Abstract Oxaliplatin is widely used in chemotherapy for colorectal cancer (CRC), but its sensitivity has become a major obstacle to limiting efficacy. Many literatures reported that Nrf2 activation promoted tumor chemoresistance. In this study, we explored the role and mechanism of inhibition oxaliplatin-based chemosensitivity CRC. vitro experiments, applied 4-octyl itaconate (4-OI) activate Nrf2, lentivirus knock down CRC cell lines. By measuring viability, colony formation, apoptosis,...
Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HCC). However, whether or not IFN-γ induces HCC cells, its biological and regulatory mechanism development progression are poorly defined. Quantitative PCR western blotting analysis were used to detect EZH2 levels cell lines stimulated with IFN-γ. Bioinformatics luciferase reporter assay...
Oxidative stress, inflammation, and apoptosis are crucial in the pathogenesis of acute liver failure (ALF). 4‐Octyl itaconate (OI) showed antioxidative anti‐inflammatory properties many disease models. However, its role lipopolysaccharide‐ (LPS‐)/D‐galactosamine‐ (D‐GalN‐) induced ALF is still not investigated. Here, we established an murine model by LPS/D‐GalN administration. And found that OI improved survival rate model. Our results also alleviated LPS/D‐GalN‐induced hepatic...
The liver is an important metabolic organ, and acute injury (ALI) potentially lethal. Itaconate, a intermediate from the tricarboxylic acid cycle, showed emerging anti-oxidative anti-inflammation properties, accumulating protective effect in multiple diseases, but its role ALI still needs to be further explored. Here we established model induced by carbon tetrachloride mice. Our results that 4-Octyl itaconate (OI), derivate of itaconate, mitigated hepatic damage improving function, reducing...
Introduction: Sepsis is a major global health challenge with high mortality rates and no effective treatment.Recent studies have suggested that sepsis may be associated immune system dysfunction.Itaconate exert anti-inflammatory effects via Nrf2 signaling.Although regulates oxidative/exogenous stress responses inhibits inflammatory responses, the mechanism which checkpoints in remains unclear.Objectives: This study aimed to investigate role of signaling pathway immunosuppression injury by...
Although PARP inhibitor (PARPi) has been proven to be a promising anticancer drug in cancer patients harboring BRCA1/2 mutation, it provides limited clinical benefit colorectal with low prevalence of mutations. In our study, we found PARPi talazoparib significantly induced cellular senescence via inhibiting p53 ubiquitination and activating p21. Furthermore, CDK4/6i palbociclib amplified this therapy-induced (TIS) vitro vivo. Mechanistically, combination senescence-associated secretory...
The most common cause of gastric cancer is infection with helicobacter pylori (HP), but the associated molecular mechanism not well understood. In present study, we found a marked increase in expression B7-H1, member B7 co-stimulatory family molecules that bind to programmed death-1 (PD-1) and play critical immunoregulatory role cell-mediated immune response, HP-positive tissue. Infection cultured cells HP promoted B7-H1 inhibited miR-152 miR-200b expression. We further demonstrated these...
Sepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic inflammation response syndrome (SIRS). Maresin 1 (Mar1) a new proresolving mediator with potent anti-inflammatory effect in several animal models. However, its sepsis still not investigated. To address this question, we developed model BALB/c mice cecal ligation and puncture (CLP) or without Mar1 treatment. Our data showed that markedly improved survival rate decreased the levels proinflammatory...
// Yaxin Wang 2 , Di 1 Gengchen Xie Yuping Yin Ende Zhao Kaixiong Tao Ruidong Li Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University Science and Technology, Wuhan 430022, China Critical Care Medicine, Correspondence to: Tao, email: tao_kaixiongg@yahoo.com Li, liruidonghust@163.com Keywords: gastric cancer, microRNA-152, B7-H1, immune response Received: December 19, 2016 Accepted: February 20, 2017 Published: March 06, ABSTRACT MiR-152 has been...
Background: Bromodomain-containing protein 4(BRD4) is reported to play a vital role in the development of numerous malignant diseases, which considered as promising target for cancer therapy.AZD5153, novel specific BRD4 inhibitor, showed potent anticancer effects several types, but its therapeutic potential has not been fully evaluated colorectal cells.Objective: We sought evaluate inhibition by AZD5153 and combined effect with PARP inhibitor BMN673 vitro vivo cancer.Methods: analyzed The...
Although triple-negative breast cancer (TNBC) is the most refractory subtype among all cancers, it has been shown to have higher immune infiltration than other subtypes. We identified marine-derived small molecule MHO7, which acts as a potent immunogenic cell death (ICD) inducer through endoplasmic reticulum (ER) stress-C/EBP-homologous protein (CHOP) pathway, treat TNBC. MHO7 exerted cytostatic and cytotoxic effects on TNBC cells at an IC50 of 0.96-1.75 µM suppressed tumor growth with...
Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect not satisfactory. Immune responsive gene 1 (IRG1) highly expressed in macrophage response to inflammatory and catalyzes production of itaconate. Studies have reported that IRG1/itaconate has significant antioxidant effect. This study aimed investigate mechanism on dextran sulfate sodium (DSS)-induced colitis vivo vitro. In experiments, we found exerted protective effects against...