A5100380659- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Microtubule and mitosis dynamics
- Zebrafish Biomedical Research Applications
- Proteoglycans and glycosaminoglycans research
- Escherichia coli research studies
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Bacterial Genetics and Biotechnology
- Gut microbiota and health
- Hippo pathway signaling and YAP/TAZ
- Biochemical effects in animals
- Antibiotic Resistance in Bacteria
- Ophthalmology and Visual Impairment Studies
- Aldose Reductase and Taurine
- Focus Groups and Qualitative Methods
- Immunotoxicology and immune responses
- Genomics, phytochemicals, and oxidative stress
- Psoriasis: Treatment and Pathogenesis
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Neurogenesis and neuroplasticity mechanisms
- China's Ethnic Minorities and Relations
- Calpain Protease Function and Regulation
- Advanced Banach Space Theory
Beijing Anzhen Hospital
2025
Capital Medical University
2025
Nankai University
2006-2024
Tianjin Economic-Technological Development Area
2011-2024
Wuhan University
2022-2024
Tianjin First Center Hospital
2024
Tianjin Medical University
2024
Jiangsu University
2023
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Although over 50 complete Escherichia coli/Shigella genome sequences are available, it is only for closely related strains, example the O55:H7 and O157:H7 clones of E. coli, that we can assign differences to individual evolutionary events along specific lineages. Here sequence genomes 14 isolates a uropathogenic coli clone persisted 3 years within household, including dog, causing urinary tract infection (UTI) in dog after 2 years. The 20 mutations observed fit single tree allows us estimate...
Heparanase (HPSE) is the endogenous endoglycosidase that degrades heparan sulfate proteoglycans and promotes tumor growth, invasion, metastasis angiogenesis. Our previous studies have shown HPSE highly expressed in neuroblastoma (NB), most common extracranial solid childhood. However, underlying regulatory mechanisms remain largely unknown. In this study, we identified one binding site of microRNA-558 (miR-558) within promoter. NB tissues cell lines, miR-558 was up-regulated positively...
Abstract Background Gram-positive bacteria of the genus Anoxybacillus have been found in diverse thermophilic habitats, such as geothermal hot springs and manure, processed foods gelatin milk powder. flavithermus is a facultatively anaerobic bacterium super-saturated silica solutions opaline sinter. The ability A. to grow makes it an ideal subject study processes sinter formation, which might be similar biomineralization that occurred at dawn life. Results We report here complete genome...
Although triple-negative breast cancer (TNBC) is the most refractory subtype among all cancers, it has been shown to have higher immune infiltration than other subtypes. We identified marine-derived small molecule MHO7, which acts as a potent immunogenic cell death (ICD) inducer through endoplasmic reticulum (ER) stress-C/EBP-homologous protein (CHOP) pathway, treat TNBC. MHO7 exerted cytostatic and cytotoxic effects on TNBC cells at an IC50 of 0.96-1.75 µM suppressed tumor growth with...
Diseases in pregnancy endanger millions of fetuses worldwide every year. The onset these diseases can be early warned by the dynamic abnormalities biochemicals amniotic fluid, thus requiring real-time monitoring. However, when continuously penetrated detection devices, amnion is prone to loss robustness and rupture, which difficult regenerate. Here, an interface-stabilized fiber sensor presented for monitoring biochemical dynamics fluid during pregnancy. seamlessly integrated into through...
In this paper the authors explore problems inherent with sampling bloggers and their blogs, specifically several factors unique to these populations: spam abandoned access-restricted non-traditional blogs. Reviewing 24 blogging studies, they focus on four strategies that researchers have employed sample blogs Internet: self-selected convenience samples, through blog hosts, assistance of aggregators or indexing websites, from ready-published lists They look closely at practicality such...
Background Calpain is activated following myocardial infarction and ablation of calpastatin (CAST), an endogenous inhibitor calpains, promotes left ventricular remodeling after (MI). The present study aimed to investigate the effect transgenic over-expression CAST on post-infarction process. Method We established mice (TG) ubiquitously over-expressing human protein produced MI in TG C57BL/6J wild-type (WT) littermates. Results expression was profoundly upregulated tissue compared with WT...
The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation during mitosis. Here, we show that ULK1, a serine/threonine kinase plays key role in initiation autophagy, also has an important function activation SAC. ULK1 phosphorylates SAC protein Mad1 at Ser546 to recruit kinetochores. Furthermore, Rod/ZW10/Zwilch (RZZ) complex may serve as receptor for phos-Ser546-Mad1 kinetochore, since phosphorylation by strengthens interaction between and RZZ complex. In addition,...
The occurrence of unilateral flagellar phase variation was previously demonstrated in Escherichia coli strains carrying the non-fliC flagellin-specifying locus flk. In this study, we investigated mechanism involved process. By using sequencing and sequence analysis, flk region between chromosomal genes yhaC rnpB characterized all described flk-positive E. strains, including H35 strain identified study (the other used are H3, H36, H47, H53 strains), found to contain a putative integrase gene...
Abstract T-helper 17 cells play a dual role in immunological responses, serving as essential components tissue homeostasis and host defense against microbial pathogens while also contributing to proinflammatory conditions autoimmunity. While transforming growth factor β1 is pivotal for the differentiation of nonpathogenic cells, β3 activin steering toward pathogenic phenotype has been acknowledged. However, molecular mechanisms governing this dichotomy remain elusive. In study, we...
Adherent-invasive
The O-antigen gene cluster of E. coli O99, which was located between galF and gnd, found to contain putative genes for the synthesis d-Rha, encoding sugar transferases, ATP-binding cassette (ABC) transporter (wzm wzt). Our findings indicate that in translocation occurs by an ABC transporter-dependent process.
Breast cancer is one of the most common types in women. Although mortality rate breast has fallen over past 10 years, effective treatments that reduce occurrence metastasis remain lacking. In this study, we explored role receptor for hyaluronan mediated motility (RHAMM) and associated signaling pathway cell migration luminal A cancer. We first examined RHAMM expression levels using human tissue microarray patient tissues. then studied loss-of-function gain-of-function strategies vitro models...
ABSTRACT MHO7 (6‐epi‐ophiobolin G), a novel component extracted from mangrove fungus, exhibits significant anticancer effects against breast cancer. However, the precise mechanism underlying of in prostate cancer (PCa) is yet to be fully elucidated. Therefore, this study was undertaken assess effect on PCa cells and elucidate its mechanism. A series vitro experiments were conducted, including Cell Counting Kit‐8, plate clone formation assays, flow cytometry analysis, electron microscopy,...
It is important to note that 2-Amino-3-methylimidazole[4,5-f]quinoline (IQ) one of the most common heterocyclic amines (HCAs), which a class mutagenic/carcinogenic harmful compounds mainly found in high-protein thermal processed foods and contaminated environments. However, pre-carcinogenic toxicity IQ liver its mechanism are poorly understood, further research needed. In light this, we exposed zebrafish (0, 8, 80, 800 ng/mL) for 35 days, followed by comprehensive experimental studies....
Abstract Background Osteosarcoma (OS) is a fatal adolescent tumor, which susceptible to remote metastases at an early stage, and its treatment remains major challenge. ubiquitin‐specific protease 10 (USP10) primarily located in the cytoplasm can therefore deubiquitinate various cytoplasmic proteins. However, expression mechanism of USP10 OS remain ambiguous. The aim this study was explore how affects Yes‐associated protein1 (YAP1) influence metastasis epithelial–mesenchymal transition (EMT)....
Diesel exhaust particles are priority pollutants in the environment due to their carcinogenicity and mutagenicity. 1-Nitropyrene (1-NP), a typical diesel nitro-polycyclic aromatic hydrocarbon, was defined as possible carcinogenic factor by International Agency for Research on Cancer. However, there is insufficient information about cancer hematogenous metastasis induced 1-NP, an urgent need determine oncogenic signaling pathway of 1-NP. Our study revealed stronger effect 1-NP endothelial...