A5100382273- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Zebrafish Biomedical Research Applications
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Hepatitis B Virus Studies
- Adipose Tissue and Metabolism
- Heavy Metal Exposure and Toxicity
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Virology and Viral Diseases
- Drug-Induced Hepatotoxicity and Protection
- Metamaterials and Metasurfaces Applications
- Cervical Cancer and HPV Research
- Viral gastroenteritis research and epidemiology
- Adenosine and Purinergic Signaling
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Plasmonic and Surface Plasmon Research
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- Retinal Development and Disorders
- Trace Elements in Health
- Venomous Animal Envenomation and Studies
Xingtai People's Hospital
2024-2025
Hebei Medical University
2024-2025
First Affiliated Hospital of Dalian Medical University
2019-2024
Zhengzhou University
2024
Dalian Medical University
2019-2024
Nankai University
2017-2023
Chinese Academy of Sciences
2011-2023
Institute of Hydrobiology
2011-2023
Chongqing Medical University
2019-2023
Second Affiliated Hospital of Chongqing Medical University
2019-2023
We design and numerically analyze a high-quality (Q)-factor, high modulation depth, multiple Fano resonance device based on periodical asymmetric paired bars in the near-infrared regime. There are four sharp peaks arising from interference between subradiant modes magnetic dipole mode that can be easily tailored by adjusting different geometric parameters. The maximal Q-factor exceed 105 magnitude, depths ΔT reach nearly 100%. Combining narrow line-widths with strong near-field confinement,...
Abstract Background Progranulin is a secreted high molecular weight growth factor bearing seven and one half copies of the cysteine-rich granulin-epithelin motif. While inappropriate over-expression progranulin gene has been associated with many cancers, haploinsufficiency leads to atrophy frontotemporal lobes development form dementia (frontotemporal lobar degeneration ubiquitin positive inclusions, FTLD-U) formation ubiquitinated inclusions. Recent reports indicate that neurotrophic...
Coarse cereal intake has been reported to be associated with reduced risk of colorectal cancer. However, evidence from intervention studies is absent and the molecular basis this phenomenon remains largely unexplored. This study sought investigate effects foxtail millet rice, two common staple grains in Asia, on progression colitis-associated cancer (CAC) define mechanism involved. In total, 40 BALB/c mice were randomized into four groups. The Normal azoxymethane/dextran sodium sulfate...
Abstract Graphene‐based metasurfaces have emerged as promising photoelectric devices that can dynamically control the behavior of electromagnetic waves. The high‐order anomalous reflection provides an additional degree freedom in field photonic research. Here, a series gradient graphene with modes to manipulate wavefront reflected light is proposed. By properly arranging nanostructures, 5‐order and 15‐order high‐quality Laguerre–Gaussian beams are achieved. Furthermore, efficiency controlled...
Background Solanum nigrum is a herbaceous perennial plant, which widely used in traditional medicine systems for its antioxidant, antiulcerogenic, antitumorigenic, and anti-inflammatory characteristics. The purpose of this study was to investigate the protective effects S. against alcoholic liver damage primary hepatocytes mice, using glutathione S-transferase alpha 1 (GSTA1) as an indicator. Methods Primary were obtained by inverse perfusion method improved on Seglen two-step situ. Results...
Adiponectin is an adipokine that exerts insulin-sensitizing and anti-inflammatory roles in insulin target tissues including liver. While the function of adiponectin has been extensively investigated, precise mechanism by which alleviates diet-induced hepatic inflammation remains elusive. Here, we report hepatocyte-specific knockout (KO) adaptor protein APPL2 enhanced sensitivity prevented mice from developing high-fat inflammation, resistance, glucose intolerance, although it caused fatty...
Monocyte proinflammatory activity has been demonstrated in obesity, insulin resistance, and type 2 diabetes, metabolic conditions that are frequently associated with elevated levels of nonesterified fatty acids (NEFA). We therefore tested the hypothesis NEFA may induce monocyte inflammation.Monocytes exposed to for days a dose-related increase intracellular reactive oxygen species (ROS) formation adhesion endothelial cells. All these effects were inhibited by coaddition antioxidants such as...
<i>Background:</i> Hepatitis B virus (HBV) infection is a severe health problem in the world; however, there still no satisfactory therapeutic strategy for HBV infection. In search new anti-HBV agents with higher efficiency and less side effects, activities of traditional Chinese medicine <i>Rheum palmatum </i>L. ethanol extract (RPE) isolated anthraquinones were evaluated. <i>Methods:</i> The RPE demonstrated stable HBV-producing cell line HepG2 2.2.15 by...
Atrial fibrillation (AF) is the most common human arrhythmia in clinical practice and may be promoted by atrial inflammation fibrosis. Ubiquitination an important posttranslational modification process that reversed deubiquitinating enzymes (DUBs). DUBs play critical roles modulating degradation, activity, trafficking, recycling of substrates. However, less research has focused on role AF. Here, we investigated effect ubiquitin C-terminal hydrolase 1 (UCHL1), DUB, development AF induced...
Irinotecan (IRI) is considered an option for second-line treatment of advanced gastric cancer; however, acquired drug resistance currently limits its clinical application. Recently, many researchers have shown that autophagy plays a crucial role in the tumor cells to chemotherapy and radiotherapy. In this study, we investigated relationship between antitumor activity IRI cancer cells.We used MTT assay, flow cytometry immunofluorescence staining detect viability, apoptosis cancer. Western...
Objective— The pathogenic role of macrophage apoptosis in atherosclerosis is still debatable, but it considered to be a suppressor plaque progression early stages promoter necrosis advanced stages. Apoptosis signal-regulating kinase 1 (ASK1) mitogen-activated protein that plays pivotal stress-induced apoptosis. In the current study, we investigated functions ASK1 hyperlipidemia-induced atherosclerosis. Methods and Results— We generated apolipoprotein E (apoE) double-knockout mice (ASK1 −/−...
Human papillomaviruses (HPV), mainly HPV16 and HPV18, of high-risk classification are involved in cervical cancer carcinogenesis progression. Octamer-binding transcription factor 4 (OCT4) is a key that increased various types. Cervical patients with higher levels OCT4 had worse survival rates. However, the definite mechanisms underlying its function development still remain to be explicated. Here, our study demonstrated expression was slightly tissues than precancerous ones. significantly...
Background Cadmium (Cd) accumulates in the body over time, damaging organs such as liver, kidneys, and brain. Some researchers have suggested that elevated blood Cd levels may contribute to onset progression of nonalcoholic fatty liver disease (NAFLD). However, only a few studies explored relationship between exposure long-term health outcomes patients with NAFLD. This study aimed evaluate predictive value cadmium for mortality risk Methods analyzed data from 13,450 NAFLD National Health...
The pathogenesis of thyroid cancer is closely related to environmental factors. Gene mutation and molecular biological changes tissue caused by are one the important factors inducing cancer. Although mechanism still not fully elucidated, with development biology technology, more cancer-specific genetic markers have been excavated. This article systematically summarizes current research progress miR-520d-5p LMO4 in cancer, discusses how they participate regulation behavior tumor cells...
Western blotting (WB) is one of the most widely used techniques to identify proteins as well post translational modifications proteins. The selection electroblotted membrane key factors affecting detection sensitivity protein which transferred from gel in WB. common membranes are polyvinylidene fluoride (PVDF) and nitrocellulose (NC) membranes. Which these two more suitable for WB has not been reported so far. Here, by incubating were PVDF or NC with a series antibodies different types...
Histocompatibility Minor 13 (HM13) is reported to participate in regulating multiple cancers. In the present study, we uncovered that HM13 was highly expressed breast cancer and correlated with worse prognosis. Downregulation of could suppress cell proliferation metastasis abilities. Tumorigenicity mediated by also observed xenograft model. Knockdown activate autophagy inducing endoplasmic reticulum (ER) stress. Moreover, further experiments demonstrated downregulated inhibit PI3K-AKT-mTOR...
Several transgenic zebrafish lines for liver development studies had been obtained in the first decade of this century, but not any GFP that mark through and organogenesis were reported. In study, we analyzed expression pattern endogenous Apo-14 embryogenesis by whole-mount situ hybridization, revealed its primordium following development. Subsequently, isolated promoter 1763 bp 5′-flanking sequence, developed an promoter-driven Tg(Apo14: GFP). And, maternal post-fertilization translocation...
Spring viremia of carp virus (SVCV) is the causative agent spring (SVC), an important infectious disease that causes high mortality in aquaculture cyprinids. How host defends against SVCV infection and underlying mechanisms are still elusive. In this study, we identify a novel gene named
Abstract Photoreceptor degeneration is one of the major causes progressive blindness which lacks curative treatment. GW2580, a highly selective inhibitor colony-stimulating factor 1 receptor, has protective potential on neurons; however, little was known about application GW2580 photoreceptor degeneration. In this study, BV-2 and 661W cells coculture system constructed to investigate interaction between microglia photoreceptors. loaded into zeolitic imidazolate framework-90-rhodamine B...
Epalrestat, an aldose reductase inhibitor (ARI), has been clinically adopted in treating diabetic neuropathy China and Japan.Apart from the involvement complications, AR implicated inflammation.Here, we seek to investigate feasibility of approved ARI, epalrestat, for treatment rheumatoid arthritis (RA).The mRNA level was markedly upregulated peripheral blood mononuclear cells (PBMCs) RA patients when compared those healthy donors.Besides, disease activity is positively correlated with...