A5100422841- Escherichia coli research studies
- Vibrio bacteria research studies
- Probiotics and Fermented Foods
- Bacterial Genetics and Biotechnology
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Aquaculture disease management and microbiota
- CRISPR and Genetic Engineering
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Antibiotic Resistance in Bacteria
- Pluripotent Stem Cells Research
- Microbial infections and disease research
- Genetic Neurodegenerative Diseases
- Urinary Tract Infections Management
- Covalent Organic Framework Applications
- Child Nutrition and Water Access
- Mitochondrial Function and Pathology
- Spectroscopy and Chemometric Analyses
- Salmonella and Campylobacter epidemiology
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Smart Agriculture and AI
Nankai University
2018-2025
Tianjin Economic-Technological Development Area
2019-2024
Huawei German Research Center
2024
Children's Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Qinghai University
2023
Ministry of Education of the People's Republic of China
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2023
East China University of Technology
2023
Tianjin University
2018-2022
Uropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infections (UTIs). Invasion into bladder epithelial cells (BECs) on the luminal surface via type 1 fimbria first critical step in UPEC infection. Although expression increases during invasion BECs, underlying regulatory mechanisms remain poorly understood. This study reported previously uncharacterized two-component system (TCS) GrpP/GrpQ that directly activates to promote and therefore pathogenicity response D-serine...
Land use change affects soil aggregate composition and stability, which impacts structure health. To reveal how land impacted aggregates of alpine grassland in a high-altitude watershed, samples from 161 sites including grassland, cropland abandoned were selected to measure analyze the distribution fractions (macro-aggregates, micro-aggregates, silt+clay), stability (mean weight diameter, geometric mean fractal dimension, etc.) related properties (soil organic carbon content, particle...
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a common food-borne pathogen that can cause acute diseases. Lysine acetylation post-translational modification (PTM) occurs in various prokaryotes and regulated by CobB, the only deacetylase found bacteria. Here, we demonstrated CobB plays an important role virulence of EHEC deletion cobB significantly decreased intestinal colonization ability Using proteomic studies, systematically identified several proteins could be O157:H7. Among these...
Summary Vibrio cholerae O1 is a natural inhabitant of aquatic environments and causes the acute diarrheal disease cholera. Entry into viable but non‐culturable (VBNC) state survival strategy by which V. withstands stresses important for transition between host during life cycle. In this study, formation VBNC induced cold seawater exposure was investigated using RNA sequencing (RNA‐seq). The analysis revealed that expression 1420 genes changed on formation. cells, related to biofilm...
The large intestinal pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 detects host cues to regulate virulence gene expression during colonization and infection. However, regulatory mechanisms of EHEC in the human intestine are not fully understood. Herein, we identified a virulence-regulating pathway where PhoQ/PhoP two-component system senses low magnesium levels signals O island 119-encoded Z4267 (LmiA; magnesium-induced regulator A), directly activating loci enterocyte...
Escherichia coli are part of the normal intestinal microbiome, but some enterohemorrhagic E. (EHEC) and enteropathogenic (EPEC) strains can cause potentially life-threatening gastroenteritis. Virulence factors underlying ability EHEC EPEC to disease include those encoded in locus enterocyte effacement (LEE) pathogenicity island. Here, we demonstrated that EsrL, a small RNA present many strains, promoted pathogenicity, adhesion, biofilm formation EPEC. PhoB, response regulator two-component...
Polymers of intrinsic microporosity (PIMs), integrating unique microporous structure and solution-processability, are one class the most promising membrane materials for energy-efficient gas separations. However, micropores generated from inefficient chain packing often exhibit wide pore size distribution, making it very challenging to achieve efficient olefin/paraffin Here, we propose a coordination-driven reconstruction (CDR) strategy, where metal ions incorporated into...
Riboflavin is produced by most commensal bacteria in the human colon, where enterohemorrhagic Escherichia coli (EHEC) colonizes and causes diseases. Sensing environmental signals to site-specifically express type-III secretion system (T3SS), which injects effectors into host cells leading intestinal colonization disease, key pathogenesis of EHEC. Here, we reveal that EHEC O157:H7, a dominant serotype frequently associated with severe diseases, acquired previously uncharacterized...
Mitochondrial dynamics are critical in cellular energy production, metabolism, apoptosis, and immune responses. Pathogenic bacteria have evolved sophisticated mechanisms to manipulate host cells' mitochondrial functions, facilitating their proliferation dissemination. Salmonella enterica serovar Typhimurium (S. Tm), an intracellular foodborne pathogen, causes diarrhea exploits macrophages for survival replication. However, S. Tm-associated during macrophage infection remain poorly...
Neonatal bacterial meningitis is associated with substantial mortality and morbidity worldwide. meningitis-causing Escherichia coli (NMEC) the most common gram-negative bacteria responsible for this disease. However, interactions of NMEC its environment within host are poorly understood. Here, we showed that a low level leucine, niche-specific signal in blood, promotes pathogenicity by enhancing survival replication blood. A leucine downregulates expression NsrP, small RNA (sRNA) identified...
Abstract Background Enterohemorrhagic Escherichia coli O157:H7 (EHEC O157) causes bloody diarrhea and hemolytic-uremic syndrome. EHEC O157 encounters varied microenvironments during infection, can efficiently adapt to these using the two-component system (TCS). Recently, a functional TCS, RstAB, has been implicated in regulation of virulence several bacterial pathogens. However, regulatory function RstAB is poorly understood. This study aimed at providing insights into global effects RstA on...
Abstract Vibrio cholerae ( V. ) is an aquatic bacterium responsible for acute and fatal cholera outbreaks worldwide. When ingested, the bacteria colonize epithelium of small intestine stimulate Paneth cells to produce large amounts cationic antimicrobial peptides (CAMPs). Human defensin 5 (HD-5) most abundant CAMPs in intestine. However, role response HD-5 remains unclear. Here we show that significantly upregulates virulence gene expression. Moreover, a two-component system, CarSR (or...
The mammalian gastrointestinal tract is a complex environment that hosts diverse microbial community. To establish infection, bacterial pathogens must be able to compete with the indigenous microbiota for nutrients, as well sense host and modulate expression of genes essential colonization virulence. Here, we found enterohemorrhagic Escherichia coli (EHEC) O157:H7 imports host- microbiota-derived L-malate using DcuABC transporters converts these substrates into fumarate fuel anaerobic...
Cytochalasins are a group of fungal secondary metabolites with diverse structures and bioactivities, including chaetoglobosin A production. Chaetoglobosin is produced by Chaetomium globosum has potential antifungal activity. Bioinformatics analysis the gene cluster (che) showed it that consists nine open reading frames, those encoding polyketide synthases (PKSs), PKS extender units, post-PKS modifications, proposed regulators. Here, role CgcheR regulator was investigated using disruption...
Rutaevin is one of the major bioactive constituents isolated from Evodia rutaecarpa, a well-known herbal medicine that has been widely prescribed for treatment gastrointestinal disorders in China. However, oral administration rutaevin shown to cause hepatotoxicity mice. Bioactivation was suggested be involved rutaevin-induced hepatotoxicity. The aim this study investigate bioactivation rat and human liver microsomes fortified with NADPH. metabolized into reactive intermediate...
EGFR C797X (C797S or C797G) mutation is the most frequent on-target mechanism of resistance to osimertinib. The hypothesis that allelic context C797X/T790M has implications for treatment on basis sporadic reports and needs validation with larger cohorts.
Adherent-invasive