A5070274049- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Vibrio bacteria research studies
- Membrane Separation Technologies
- Trace Elements in Health
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Wastewater Treatment and Nitrogen Removal
- Microbial Metabolic Engineering and Bioproduction
- Gut microbiota and health
- Electrochemical Analysis and Applications
- Advancements in Battery Materials
- Bacterial Genetics and Biotechnology
- Fermentation and Sensory Analysis
- Biochemical effects in animals
- Cancer Research and Treatments
- Electrochemical sensors and biosensors
- Plant Disease Resistance and Genetics
- Constructed Wetlands for Wastewater Treatment
- Supercapacitor Materials and Fabrication
- Antibiotic Resistance in Bacteria
- Biofuel production and bioconversion
- Legume Nitrogen Fixing Symbiosis
- Water Quality Monitoring and Analysis
- Protein Kinase Regulation and GTPase Signaling
Nankai University
2014-2025
Tianjin Economic-Technological Development Area
2018-2024
Ministry of Education of the People's Republic of China
2009-2024
Revolution Medicines (United States)
2023-2024
Ocean University of China
2024
Shenzhen Second People's Hospital
2021-2024
Nanjing Medical University
2023
Soochow University
2023
Shandong Institute of Food and Drug Inspection
2023
University of Electronic Science and Technology of China
2019-2022
A two step programmed method is developed to load mono dispersed SnO2 nanoparticles onto single layer graphene sheets. The SnO2-G composite has near dispersion of the nanocrystals as well a high content over 60 wt%. These outstanding features are desirable and enable material be an excellent anode for Li-ion batteries.
RuO2/CNT nanocomposites with well-dispersed RuO2 nanoparticles (diameter <2 nm) on the carbon nanotubes' surface, synthesized through an easy and efficient solution-based method, have been investigated for potential application in electrochemical capacitors (ECs) as electrode materials. The results demonstrate that supporting material of CNT can significantly promote supercapacitance performance RuO2. composite a mass ratio 6:7 could achieve specific capacitance high 953 F g−1. also resulted...
Abstract Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S . exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on synthesis are mediated bacterial protein SopE2, a type III secretion system (T3SS) effector encoded pathogenicity island SPI-1. changes metabolism promote intracellular replication via two mechanisms: glucose levels...
Abstract RAS oncogenes (collectively NRAS , HRAS and especially KRAS ) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 61 1 . Small molecule inhibitors of KRAS(G12C) oncoprotein have demonstrated clinical efficacy patients multiple cancer types led to regulatory approvals for treatment non-small cell lung 2,3 Nevertheless, G12C account only around 15% -mutated cancers 4,5 there no approved majority tumours containing other...
Abstract Broad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human patients with cancer whose tumours are driven by mutations 1,2 . RMC-7977 is highly selective inhibitor active GTP-bound forms KRAS, HRAS and NRAS, affinity for both mutant wild-type variants 3 More than 90% cases pancreatic ductal adenocarcinoma (PDAC) activating in KRAS 4 Here we assessed therapeutic comprehensive range PDAC models. We observed broad pronounced anti-tumour activity across models...
A beaker-in-autoclave setup is designed for interfacial synthesis of Fe3O4 nanoparticles with precise size control. They exhibit superparamagnetic properties and can be homogeneously incorporated into a carbon matrix to form Fe3O4@C composite, in which remains highly dispersed the solid state. The composites excellent cycling rate performances as anode material lithium-ion batteries.
Well-organized carbon nanotube (CNT)@TiO2 core/porous-sheath coaxial nanocables are synthesized by controlled hydrolysis of tetrabutyl titanate in the presence CNTs, and investigated with scanning electron microscopy, transmission X-ray diffraction, electrochemical experiments. The CNT@TiO2 show excellent rate capability cycling performance compared both pure CNT TiO2 when used as anode materials for lithium-ion batteries (LIBs). Both specific capacity core that sheath much higher than...
Hierarchical flower-like SnO2 nanomicrostructure has been synthesized via a solvent-induced and surfactant assisted self-assembly technique at ambient temperature followed by suitable thermal treatment. A possible growth mechanism governing the formation of such is discussed. The applications in gas sensors for detecting CO H2 reveal that obtained material exhibits remarkable sensitivity extremely low limit (5 ppm), as well good reproducibility short response/recovery times, which benefit...
Uropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infections (UTIs). Invasion into bladder epithelial cells (BECs) on the luminal surface via type 1 fimbria first critical step in UPEC infection. Although expression increases during invasion BECs, underlying regulatory mechanisms remain poorly understood. This study reported previously uncharacterized two-component system (TCS) GrpP/GrpQ that directly activates to promote and therefore pathogenicity response D-serine...
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major intestinal pathogen of both humans and animals. pathogenicity island 1 (SPI-1)-encoded virulence genes are required for S. invasion. While oxygen (O2) limitation an important signal SPI-1 induction under host conditions, how the received integrated to central regulatory system in not clear. Here, we report transduction pathway that activates expression response low O2. A novel regulator encoded within SPI-14 (STM14_1008),...
Cr2O3-based nanospheres have been synthesized by a facile soft-template assisted method without sacrificing the template. Two types of Cr2O3 materials, Cr2O3–C composite (referred to as Cr2O3–C) with novel hierarchical core/shell structure, and pure mesoporous spheres Cr2O3) obtained using certain thermal treatment adding more carbon precursor. The coating layers in distribute from inside surface continuously. Both are investigated XRD, SEM, TEM, electrochemical tests toward lithium storage....
Clostridium acetobutylicum is a model fermentative anaerobe for consolidated bioprocessing of lignocellulose hydrolysates into acetone-butanol-ethanol (ABE). However, the main inhibitors (acids, furans and phenols) ubiquitous in strictly limit conversion efficiency. Thus, it essential to understand underlying mechanisms hydrolysate identify key industrial bottlenecks that undermine efficient biofuel production. The recently developed omics strategy intracellular metabolites protein...
ABSTRACT Salmonella is one of the most important enteric pathogens worldwide, which able to cause lethal systemic infection via survival and replication in host macrophages. Lactate, a byproduct anaerobic or aerobic glycolysis, can induce macrophage M2 polarization, but relationship between lactate-mediated polarization bacterial poorly understood. Here, we evaluated role lactate pathogenicity . We found that levels were significantly increased -infected macrophages, was derived from host....
Aims: To evaluate the interrelation between neutrophil to lymphocyte ratio (NLR) coupled with gene signatures, inflammation, and diastolic dysfunction in patients heart failure (HF) preserved ejection fraction (HFpEF). Methods: The clinical profile of 172 HFpEF (EF ≥ 50%) 173 non-HF control individuals was analyzed retrospectively. association NLR predictive performance for were assessed by binary logistic regression analysis receiver operating characteristic curve (ROC). Multivariate linear...
Ultrasound has been widely used for physical modifications of starch because its effectiveness and environment friendliness; however, only a few reports have focused on the effect varying ultrasonic treatments physicochemical properties potato flour. In present study, ultrasound at power levels (200, 300, 400, 500, 600 W) time intervals (20, 40, 60, 80, 100 min) were to obtain sonicated Sonicated flour exhibited significant (P < 0.05) decrease in blue value oil holding capacity but an...
Citrobacter species are opportunistic bacterial pathogens that have been implicated in both nosocomial and community-acquired infections. Among the genus Citrobacter, koseri is often isolated from clinical material, has known to cause meningitis brain abscess neonates immunocompromised individuals. The virulence determinants of however, remain largely unknown. Based on traditional methods, divided into 11 species, but this problematic. Here, we determined an improved, fine scale, more...
The taxonomic position of P. shigelloides has been the subject debate for a long time, and until now, evolutionary dynamics pathogenesis were unclear. In this study, pan-genome analysis indicated extensive genetic diversity presence large variable gene repertoires. Our results revealed that horizontal transfer was focal driving force might have contributed to emergence novel properties. Vibrionaceae Aeromonadaceae found be predominant donor taxa genes, which caused confusion historically....