A5100317955- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Ion Channels and Receptors
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- Neurobiology and Insect Physiology Research
- IL-33, ST2, and ILC Pathways
- Amino Acid Enzymes and Metabolism
- Cancer Cells and Metastasis
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- interferon and immune responses
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Erythrocyte Function and Pathophysiology
- Cancer Research and Treatments
- Spaceflight effects on biology
- Antimicrobial Peptides and Activities
- Galectins and Cancer Biology
Huazhong University of Science and Technology
2017-2025
Union Hospital
2017-2025
University of Michigan–Ann Arbor
2006-2020
Union Hospital
2018
Michigan United
2016
Institute of High Energy Physics
2013
Chinese Academy of Sciences
2013
Whether mutations in cancer driver genes directly affect immune phenotype and T cell immunity remains a standing question. ARID1A is core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. occur human cancers drive development. Here, we studied molecular, cellular, clinical impact aberrations on immunity. We demonstrated that resulted limited accessibility to IFN-responsive genes, impaired IFN gene expression, anemic tumor infiltration, poor immunity, shortened...
The expression and biological role of IL33 in colon cancer is poorly understood. In this study, we show that expressed by vascular endothelial cells tumor the human microenvironment. Administration overexpression murine enhanced cell growth vivo, respectively. stimulated sphere formation prevented chemotherapy-induced apoptosis. Mechanistically, activated core stem genes NANOG, NOTCH3, OCT3/4 via ST2 signaling pathway, induced phosphorylation c-Jun N terminal kinase (JNK) activation binding...
Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing antigen dosage and frequency while maintaining immunity levels inducing TEM-biased combat infection at early stage. The underlying mechanisms by fullerenol-based formulation induces above-mentioned polyvalent are involved in activating...
Naïve T cells are poorly studied in cancer patients. We report that naïve prone to undergo apoptosis due a selective loss of FAK family-interacting protein 200 kDa (FIP200) ovarian patients and tumor-bearing mice. This results poor antitumor immunity via autophagy deficiency, mitochondria overactivation, high reactive oxygen species production cells. Mechanistically, FIP200 disables the balance between proapoptotic antiapoptotic Bcl-2 family members enhanced argonaute 2 (Ago2) degradation,...
The primary objective of this study was to examine whether ARID1A mutations confer a fitness advantage gastric cancer from an immunological perspective, along with elucidating the underlying mechanism. Additionally, we aimed identify clinical potential combining epigenetic inhibitors immune checkpoint improve efficacy immunotherapy for cancer. correlation between gene expression and patient survival analyzed using GEO dataset GSE62254. association chemokines (CXCL9, CXCL10) conducted...
Abstract Naive T cells are thought to be functionally quiescent. In this study, we studied and compared the phenotype, cytokine profile, potential function of human naive CD4+ in umbilical cord peripheral blood. We found that cells, but not memory expressed high levels chemokine CXCL8. CXCL8+ were preferentially enriched CD31+ did express cell activation markers or typical Th effector cytokines, including IFN-γ, IL-4, IL-17, IL-22. addition, upon activation, retained CXCL8 expression....
Nearly all species employ mechanosensitive channels to detect mechanical cues, such as touch and sound waves, convert these forces into electrochemical signals. Genetic, biochemical electrophysiological studies of touch-insensitive mutants in model organisms Caenorhabditis elegans Drosophila melanogaster provide insights the molecular basis mechanosensory transduction.
Abstract Glycolysis is considered a hallmark of cancer. However, its involvement in tumor immune regulation and breast cancer stem cell biology poorly understood. Here we investigated how glycolysis affected the development myeloid derived suppressor cells (MDSCs) turn controlled stemness G-CSF promotes MDSC 4T1 model. We found that knock down LDH-A resulted decreased production reduced numbers. Accompanied with these findings was inhibited glycolysis, potential, increased mouse survival....