A5064505008- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Immune cells in cancer
- Endometriosis Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Polish Historical and Cultural Studies
- Language and Culture
- Natural Antidiabetic Agents Studies
- Uterine Myomas and Treatments
- Health, Work, and Social Studies in Poland
- MicroRNA in disease regulation
- Central European Literary Studies
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- Dermatology and Skin Diseases
- Ginkgo biloba and Cashew Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Education and Cultural Studies
- Liver Disease Diagnosis and Treatment
- Theology and Canon Law Studies
Medical University of Lublin
2017-2024
Pontifical University of John Paul II in Kraków
2015
Wyższa Szkoła Humanistyczna
2015
Uniwersytecki Szpital Kliniczny w Olsztynie
2010
Ovarian cancer (OC) is usually diagnosed at an advanced stage and related with poor prognosis. Despite numerous studies, the pathogenesis of OC still unknown. Recent studies indicate role immune system in development spread OC. The identification factors mechanisms involved that process their modulation crucial for creating effective antitumor therapy. We investigated potential Th17 cells patients ( n = 71) by analyzing frequencies three different environments, i.e., peripheral blood (PB),...
The latest literature demonstrates the predominant role of programmed cell death axis (PD-1/PD-L1/PD-L2) in ovarian cancer (OC) pathogenesis. However, data concerning this issue is ambiguous. Our research aimed to evaluate clinical importance PD-L1/PD-L2 expression OC environments. We evaluated patients (n = 53). analysis was performed via flow cytometry on myeloid (mDCs) and plasmacytoid dendritic cells (pDCs) monocytes/macrophages (MO/MA) peripheral blood, peritoneal fluid (PF), tumor...
Endometrial cancer (EC) is one of the most common malignant tumors among women in 21st century, whose mortality rate increasing every year. Currently, diagnosis EC possible only after a biopsy. However, it necessary to find new biomarker that will help both and treatment non-invasive way. Circular RNAs (circRNAs) are small, covalently closed spherical stable long non-coding (lncRNAs) molecules, which abundant body fluids human tissues expressed various ways. Considering molecular...
Immune system dysregulation is clinically evident in the pathogenesis of endometriosis (EMS). Changes dendritic cells (DCs) activity or phenotype may be involved implantation and growth endometrial tissue outside uterus disease. The TIM-3/Gal-9 axis implicated development immune tolerance. However, knowledge about exact role this pathway EMS extremely poor. In present study, we evaluated expression Gal-9 on myeloid DCs (mDCs) plasmacytoid (pDCs) peripheral blood (PB) peritoneal fluid (PF)...
Endometriosis (EMS) is an oestrogen-dependent, chronic disease affecting women of a reproductive age. One the important factors involved in development this complex disorders associated with functioning immune system. Recent evidence has shown that EMS changes systemic and local immunity, including functional disturbances effector antigen-presenting cells. reasons for imbalance can be improper expression checkpoints (ICPs). ICPs their ligands are responsible maintaining self-tolerance...
The aim of this study was to determine the anti-tumor activity extracts isolated from Potentilla alba L. on human colon cancer cells HT-29 line and non-cancer epithelial CCD 841 CoTr line. research methods we used cytotoxic proliferative properties were 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) neutral red (NR) assays, ability produce nitric oxide, Griess method, biochemical like 2,2-diphenyl-1-picrylhydrazyl (DPPH) ferric reducing antioxidant power (FRAP) indicating...
Ovarian cancer (OC) is one of the deadliest gynecological cancers. Recent studies suggest a crucial role inflammatory immune system cells in progression and metastasis OC. The understanding mechanisms pivotal for selection biomarker that allows differentiation between malignant benign tumors, monitoring disease, identification patients will respond to implemented treatment. Our study aimed at evaluating profile IL-6 plasma peritoneal fluid (PF) with various clinical manifestations OC...
Ovarian cancer (OC) is one of the most lethal gynecological malignancies. Recent studies suggest a crucial role PD-1/PD-L1 pathway in OC pathogenesis. Therefore, our study aimed at evaluation clinical importance PD-1 expression ovarian patients.In this study, we investigated patients (n=50) by analyzing its on CD4+ and CD8+ T cells three environments: peripheral blood (PB), peritoneal fluid (PF), tumor (TT) as well soluble (sPD-1) plasma PF terms their prognostic significance. with were...
The interaction between dendritic cells (DCs) and T mediated by the programmed cell death 1 (PD-1)/programmed ligand (PD-L1)/programmed 2 (PD-L2) pathway is most important point in regulating immunological tolerance autoimmunity. Disturbances quantity, maturity, activity of DCs may be involved implantation growth endometrial tissue outside uterus endometriosis (EMS). However, little known about role immune checkpoint pathways EMS. In our study, we examined expression PD-L1/PD-L2 on myeloid...
Endometrioza diagnozowana jest u około 5-10% kobiet w wieku rozrodczym i charakteryzuje się występowaniem tkanki endometrium poza jamą macicy.Przemieszczone komórki mają zdolność naciekania okolicznych tkanek odległych narządów, co prowadzi do ich dysfunkcji
<h3>Objectives</h3> The aim of the study was evaluation Th17 cells in patients with different clinicalmanifestation ovarian cancer (OC) three environment: peripheral blood (PB),peritoneal fluid (PF) and tissue (TT), establish their role OC pathogenesis. <h3>Methods</h3> included 59 OC, 35 women benign tumors and10 healthy donors. percentage analyzed by flowcytometry.Th17 were as CD4 + intracellularexpression IL-17A. <h3>Results</h3> highest detected among tumor infiltrating +lymphocytes it...