A5086754636- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- Immune cells in cancer
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Biomarkers in Disease Mechanisms
- Cannabis and Cannabinoid Research
- Pharmacological Receptor Mechanisms and Effects
- Neurotransmitter Receptor Influence on Behavior
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- T-cell and B-cell Immunology
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Macrophage Migration Inhibitory Factor
- Cancer Cells and Metastasis
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
Medical University of Lublin
2020-2024
Endometrial cancer (EC) is one of the most common malignant tumors among women in 21st century, whose mortality rate increasing every year. Currently, diagnosis EC possible only after a biopsy. However, it necessary to find new biomarker that will help both and treatment non-invasive way. Circular RNAs (circRNAs) are small, covalently closed spherical stable long non-coding (lncRNAs) molecules, which abundant body fluids human tissues expressed various ways. Considering molecular...
Immune system dysregulation is clinically evident in the pathogenesis of endometriosis (EMS). Changes dendritic cells (DCs) activity or phenotype may be involved implantation and growth endometrial tissue outside uterus disease. The TIM-3/Gal-9 axis implicated development immune tolerance. However, knowledge about exact role this pathway EMS extremely poor. In present study, we evaluated expression Gal-9 on myeloid DCs (mDCs) plasmacytoid (pDCs) peripheral blood (PB) peritoneal fluid (PF)...
Endometriosis (EMS) is an oestrogen-dependent, chronic disease affecting women of a reproductive age. One the important factors involved in development this complex disorders associated with functioning immune system. Recent evidence has shown that EMS changes systemic and local immunity, including functional disturbances effector antigen-presenting cells. reasons for imbalance can be improper expression checkpoints (ICPs). ICPs their ligands are responsible maintaining self-tolerance...
Ovarian cancer (OC) is one of the deadliest gynecological cancers. Recent studies suggest a crucial role inflammatory immune system cells in progression and metastasis OC. The understanding mechanisms pivotal for selection biomarker that allows differentiation between malignant benign tumors, monitoring disease, identification patients will respond to implemented treatment. Our study aimed at evaluating profile IL-6 plasma peritoneal fluid (PF) with various clinical manifestations OC...
The interaction between dendritic cells (DCs) and T mediated by the programmed cell death 1 (PD-1)/programmed ligand (PD-L1)/programmed 2 (PD-L2) pathway is most important point in regulating immunological tolerance autoimmunity. Disturbances quantity, maturity, activity of DCs may be involved implantation growth endometrial tissue outside uterus endometriosis (EMS). However, little known about role immune checkpoint pathways EMS. In our study, we examined expression PD-L1/PD-L2 on myeloid...
<h3>Introduction/Background</h3> Endometrial cancer (EC) is the most common gynaecological and second female malignancy in world. Gal-9 a ligand for TIM-3 which on surface of T cells, eosinophils or dendritic cells. The high concentration may bring to apoptosis activated has been proven play therapeutic role autoimmune disease. management remains challenging important deeper understanding immunology diversity this cancer. study aimed evaluate concentrations soluble plasma patients with...
<h3>Introduction/Background</h3> Endometrial cancer (EC) is the most common gynecological and second female malignancy in developed world. Circulating soluble programmed death-2 ligand (sPD-L2) plays a crucial role within tumor microenvironment for tumorigenesis. Not much known about functional consequence of cell surfaced-expressed PD-L2 or sPD-L2 oncologic diseases, but understanding molecular alterations involved endometrial provides personalized treatments through incorporation targeted...