A5000391659- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Gynecological conditions and treatments
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Growth Hormone and Insulin-like Growth Factors
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Intestinal and Peritoneal Adhesions
- Hemodynamic Monitoring and Therapy
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Music Therapy and Health
- Angiogenesis and VEGF in Cancer
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- Cervical Cancer and HPV Research
Medical University of Lublin
2016-2025
Optimum Technologies (United States)
2020
Hofstra University
2015-2017
Lublin Oncology Center
2016
Yahoo (United Kingdom)
2016
University of Economics and Innovation
2003-2013
Instytut Medycyny Wsi im. Witolda Chodźki
1999-2001
Endometriosis is a chronic, hormone-dependent disease characterized by the presence of endometrial tissue in ectopic locations. Since treatment options for this are still limited, and cure rate unsatisfactory, search ways to treat symptoms modify course key importance improving quality life patients with endometriosis. So far, literature has shown that nutrition can influence endometriosis through hormonal modification altering inflammatory or oxidative response. subject scientific research,...
The most common manifestation of endometriosis, a condition characterized by the presence endometrial-like tissue outside uterus, is endometrioma, cystic ovarian lesion. It commonly occurring associated with chronic pelvic pain exacerbated prior to and during menstruation, as well infertility. exact pathomechanisms endometrioma are still not fully understood. Emerging evidence suggests pivotal role immune dysregulation in pathogenesis endometriomas, primarily influencing both local systemic...
Endometriosis in half of affected women is closely related to problems with fertility. Endometriosis-associated infertility caused by a wide range abnormalities affecting the female reproductive tract, from oocyte quality impairment disturbances eutopic endometrium or mechanical resulting disease progression. Since supportive antioxidant therapies, addition surgical treatment assisted techniques (ARTs), have overall been proven be effective tools endometriosis management, objective our...
Cancer during pregnancy is a rare condition involving neoplasm diagnosed or within year after labor. symptoms may be masked by symptoms, which might delay diagnosis and proper treatment. Another phenomenon the occurrence of multiple primary malignancies. This defined as appearance two more unrelated neoplasms in one individual, can located same various organs. The risk increased due to advances cancer treatment, resulting growing population survivors. Since co-occurrence both conditions has...
Ultrasound-guided transvaginal ethanol sclerotherapy is one of the methods for ovarian endometrioma treatment. It involves aspiration cyst content and subsequent administration some fibrosis agent. This minimally invasive procedure does not reduce reserve hence, it addressed to patients with fertility plans. To date, there have been no reports this method being used in advanced disease stages. Therefore, we present a case patient deep infiltrating endometriosis who underwent treatment...
The study was undertaken to evaluate macrophage-derived chemokine (CCL22) levels in the peritoneal fluid (PF) and plasma of patients with ovarian cancer (n = 93) relation regulatory T cells (Tregs; n 75). CCL22 concentrations were significantly higher epithelial (EOC) than benign tumors-serous cystadenoma 32). There no difference EOC compared non-cancer healthy volunteers 10). significant differences PF based on tumor grade. However, women stage IV FIGO (International Federation...
The cause of endometriosis remains unknown. However, studies investigating the link between this condition and immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major checkpoint, programmed cell death protein 1 (PD-1) displays an important inhibitory function in maintenance peripheral tolerance. expression PD-1 its ligand (PD-L1) may contribute to continuous T activation development inflammation injury tissue. To our knowledge, is first study...
Endometriosis is a common disease, affecting up to 60-80% of women, with pelvic pain or/and infertility. Despite years studies, its pathogenesis still remains enigmatic. Genetic, hormonal, environmental, and lifestyle-related factors may be involved in pathogenesis. Thus, the design review was discuss possible role environmental development endometriosis. The results individual studies greatly differ, making it very difficult draw any definite conclusions. There no reasonable consistency...
Data on the possible role of peritoneal fluid free radical-mediated oxidative damage in pathogenesis endometriosis still remains inconsistent. The aim study was to determine iron metabolism markers and their influence stress arameters women with endometriosis.110 119 patients benign ovarian cysts were included study. All visible aspirated during laparoscopy from anterior posterior cul-de-sacs. under direct vision avoid blood contamination. Haemoglobin, iron, total status, antioxidant status...
Abstract The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. Muller F element (∼5.2 Mb) is smallest chromosome Drosophila melanogaster, but it substantially larger (>18.7 D. ananassae. To identify major contributors expansion assess their impact, we improved sequence annotated genes a 1.4-Mb region ananassae element, 1.7-Mb from D for comparison. We find that transposons (particularly LTR LINE...
Immune system dysregulation is clinically evident in the pathogenesis of endometriosis (EMS). Changes dendritic cells (DCs) activity or phenotype may be involved implantation and growth endometrial tissue outside uterus disease. The TIM-3/Gal-9 axis implicated development immune tolerance. However, knowledge about exact role this pathway EMS extremely poor. In present study, we evaluated expression Gal-9 on myeloid DCs (mDCs) plasmacytoid (pDCs) peripheral blood (PB) peritoneal fluid (PF)...
Abstract Background: Evaluation of immature myeloid and lymphoid dendritic cells (DCs) in the peritoneal fluid (PF) peripheral blood (PB) mononuclears women with ovarian carcinoma ( n = 47) benign tumors 37). Methods: Mononuclear were isolated from PF PB, stained monoclonal antibodies (mAbs) against DC antigens (anti‐BDCA‐1, anti‐BDCA‐2), estimated using flow cytometry. Results: The percentage (MDC) was significantly lower patients cancer comparison to group nonmalignant (0.65% 6.95%). DCs...
The etiopathogenesis of endometriosis still remains unknown. Recent data provide new valuable information concerning the role oxidative stress in pathophysiology disease. It has been proved that levels different lipid peroxidation end products are increased both peritoneal fluid (PF) and serum endometriotic patients. We assessed concentration oxidized low-density lipoproteins (oxLDL) PF 110 women with stages 119 serous (n = 78) or dermoid 41) ovarian cysts, as reference groups. oxLDL were...
Anti-Müllerian hormone (AMH) is a glycoprotein produced by the granulosa cells of preantral and small antral follicles. AMH concentrations reflect ovarian physiology with high precision, thus serving as more sensitive marker reserve than chronological age. This plays role in pathogenesis menstrual disorders fertility obesity polycystic ovary syndrome. The evaluation may also be useful diagnosis or monitoring therapy tumors.
The molecular bases of miR‐182 deregulation in epithelial ovarian cancers (EOCs) remain unknown and its diagnostic or prognostic role EOCs is still unclear. We performed expression analysis using a microarray approach real‐time PCR (qPCR). also used array comparative genomic hybridization methylated DNA immunoprecipitation to study copy number changes methylation aberrations within coding locus/promoter sequences EOC tissues, respectively. have found that significantly increased ( P <...
Altered immune mechanisms are implicated in the pathogenesis of endometriosis. CTLA-4 is a membrane receptor that favors anergic state lymphocytes, which may disrupt system response endometriotic environment. In this study, we examined expression on T and B cells by flow cytometry its levels blood serum peritoneal fluid ELISA. Levels CTLA-4+ were significantly higher patients with more advanced endometriosis than those less disease. Additionally, negative correlation lymphocytes percentage...
The interaction between dendritic cells (DCs) and T mediated by the programmed cell death 1 (PD-1)/programmed ligand (PD-L1)/programmed 2 (PD-L2) pathway is most important point in regulating immunological tolerance autoimmunity. Disturbances quantity, maturity, activity of DCs may be involved implantation growth endometrial tissue outside uterus endometriosis (EMS). However, little known about role immune checkpoint pathways EMS. In our study, we examined expression PD-L1/PD-L2 on myeloid...