A5019379949- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Hormonal and reproductive studies
- Uterine Myomas and Treatments
- Hormonal Regulation and Hypertension
- Lipid metabolism and disorders
- Menstrual Health and Disorders
- Intestinal and Peritoneal Adhesions
- Cancer, Lipids, and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ginseng Biological Effects and Applications
- Reproductive tract infections research
- Cardiovascular Disease and Adiposity
- Growth Hormone and Insulin-like Growth Factors
- Endometrial and Cervical Cancer Treatments
- Apelin-related biomedical research
- Genetics and Physical Performance
- Optimism, Hope, and Well-being
- Hair Growth and Disorders
- Gynecological conditions and treatments
- Vitamin D Research Studies
- Effects and risks of endocrine disrupting chemicals
Poznan University of Medical Sciences
2013-2025
Semnan University
2023
University of California, Davis
2007-2012
Weatherford College
2007
Yale University
2005-2007
A majority of women with polycystic ovary syndrome (PCOS) have metabolic abnormalities that result in an increased risk developing type 2 diabetes and heart disease. Correlative studies shown association between changes the gut microbiome disorders. Two recent reported a decrease α diversity PCOS compared healthy women.We investigated whether correlated specific clinical parameters women. We also there were ovarian morphology (PCOM) who lacked other diagnostic criteria PCOS.Subjects...
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Hyperandrogenism central feature PCOS. Studies on isolated ovarian theca-interstitial cells suggest that resveratrol, a natural polyphenol, reduces androgen production.This study was designed to evaluate endocrine and metabolic effects resveratrol PCOS.This randomized (1:1) double-blind, placebo-controlled trial evaluated over period 3 months in an academic hospital.Subjects with PCOS were...
Context: Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and cardiovascular risks including dyslipidemia systemic inflammation. In vitro, statins decrease proliferation steroidogenesis of ovarian theca-interstitial cells.
A randomized trial on women with polycystic ovary syndrome (PCOS) compared simvastatin, metformin, and a combination of these drugs.The aim the study was to evaluate long-term effects simvastatin metformin PCOS.Women PCOS (n = 139) were (S), (M), or plus (SM) groups. Evaluations performed at baseline 3 6 months.The conducted university medical center.We measured change serum total testosterone.Ninety-seven subjects completed study. Total testosterone decreased significantly comparably in all...
Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction and hyperandrogenism; it also associated with increased cardiovascular risks such as adverse lipid profile endothelial dysfunction. Metformin and, more recently, statins have been shown to improve endocrine metabolic aspects of PCOS.The aim the study was compare effects simvastatin metformin on PCOS.In a prospective trial, women PCOS (n = 136) were randomized (S), (M), or plus (SM) groups. Evaluations performed at...
Abstract STUDY QUESTION Are there specific autoantibody profiles in patients with endometriosis that are different from those controls? SUMMARY ANSWER This study did not reveal a significantly higher prevalence of autoantibodies the studied groups patients. WHAT IS KNOWN ALREADY Various inflammatory factors postulated to be involved pathomechanisms endometriosis, and potential link exists autoimmune diseases, which may also play an important role. As diagnosis remains invasive, it can only...
Polycystic ovary syndrome (PCOS) is a complex condition with clear genetic susceptibilities that impact the heterogeneous clinical presentation of symptoms and severity through unknown mechanisms. Chronic inflammation linked to PCOS, but cause-and-effect relationship has yet be established. This study used an in depth systems immunology approach letrozole-induced PCOS mouse model identify changes inflammatory factors associated symptoms. By analyzing immune cells secreted cytokines from 22...
Endometriosis is a common disease, affecting up to 60-80% of women, with pelvic pain or/and infertility. Despite years studies, its pathogenesis still remains enigmatic. Genetic, hormonal, environmental, and lifestyle-related factors may be involved in pathogenesis. Thus, the design review was discuss possible role environmental development endometriosis. The results individual studies greatly differ, making it very difficult draw any definite conclusions. There no reasonable consistency...
An evaluation of the association between concentrations vitamin D-binding protein and lactoferrin in plasma peritoneal fluid may facilitate elucidation molecular mechanisms endometriosis. Vitamin were measured by ELISA samples from 95 women with suspected endometriosis as classified laparoscopy into groups (n = 59) without 36). There no differences (p > 0.05) In endometriosis, there was a significant correlation (r 0.821; p 0.000), but those compartments 0.049; 0.05). Furthermore, found...
The aim of this study was to investigate the relationship between lactoferrin and iron its binding proteins in women with endometriosis by simultaneously measuring these parameters plasma peritoneal fluid. Ninety were evaluated, whom 57 confirmed as having endometriosis. Lactoferrin measured ELISA, transferrin, ferritin on a Cobas 8000 analyser. transferrin fluid lower compared plasma, contrast iron. In showeds associations group without correlated lactoferrin, patients ratio concentration...
Is polycystic ovary syndrome (PCOS) associated with an elevation of markers endotoxemia?In women PCOS serum levels lipopolysaccharides (LPS), the LPS to high-density lipoprotein (HDL) ratio and LPS-binding protein (LBP) are significantly greater than those normal control subjects.Mononuclear cells from respond excessively by releasing pro-inflammatory cytokines. In rat ovarian theca-interstitial cell cultures stimulates androgen production.Cross-sectional study comparing endotoxemia in (n =...
Abstract Context Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Objective This study was designed to evaluate effects lifestyle modifications and synbiotic supplementation on PCOS. Design A randomized (1:1) double-blind, placebo-controlled trial. Setting Academic hospital. Patients or Other Participants Overweight obese with PCOS were identified according Rotterdam criteria. Evaluations performed at baseline repeated after 3 months...
Laparoscopy as a diagnostic tool for patients with suspected endometriosis is associated several potentially life-threatening complications. Therefore, it imperative to identify reliable, non-invasive biomarkers of the disease. The aim this study was analyse concentrations fibronectin and type IV collagen in peritoneal fluid plasma assess their role potential diagnosis endometriosis. Fibronectin protein levels were assessed by surface plasmon resonance imaging (SPRi) biosensors usage...
Cadherin 12 (CDH 12) can play a role in the pathogenesis of endometriosis. The aim this study was to compare levels cadherin peritoneal fluid between women with and without This multicenter cross-sectional study. Eighty-two patients undergoing laparoscopic procedures were enrolled concentrations determined using enzyme-linked immunosorbent assay. level statistical significance set at p < 0.05. No differences endometriosis observed (p = 0.4). Subgroup analyses showed that CDH significantly...
The aim of the study was to assess prevalence and severity emotional problems among Polish women with polycystic ovary syndrome (PCOS) seek factors which increase risk their occurrence.The group consisted 82 (aged 18-48), who were diagnosed PCOS based on Rotterdam criteria. During hospitalization, patients completed a number questionnaires, providing sociodemographic data information concerning inconvenience disease-associated symptoms. question-naires included Beck Depression Inventory...
Abstract Embryo–fetal exposure to bisphenol A (BPA) could be related poor male reproductive parameters in rodents, but this concept has not been convincingly confirmed humans. We investigated the association of environmental BPA pregnant women with selected endocrine and anthropometric newborns. analyzed plasma from mothers, umbilical cord, placental tissues ( n = 117/each group) by liquid chromatography mass spectrometry. LH, FSH, AMH, TGFβ2, inhibin B, sex steroids were measured cord...