A5069796009- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Iron Metabolism and Disorders
- Birth, Development, and Health
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Hemoglobinopathies and Related Disorders
- Endometriosis Research and Treatment
- Vitamin D Research Studies
- Reproductive System and Pregnancy
- Metabolism and Genetic Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal and Maternal Infections
- Breastfeeding Practices and Influences
- Intestinal and Peritoneal Adhesions
- Folate and B Vitamins Research
- Vitamin K Research Studies
- Neuroblastoma Research and Treatments
- Traditional Chinese Medicine Analysis
- Gestational Diabetes Research and Management
- Machine Learning in Bioinformatics
- Glycosylation and Glycoproteins Research
- Pediatric Hepatobiliary Diseases and Treatments
- Health, Work, and Social Studies in Poland
Medical University of Warsaw
2016-2024
Instytut Matki i Dziecka
2020
Instytut Farmaceutyczny
1996
An evaluation of the association between concentrations vitamin D-binding protein and lactoferrin in plasma peritoneal fluid may facilitate elucidation molecular mechanisms endometriosis. Vitamin were measured by ELISA samples from 95 women with suspected endometriosis as classified laparoscopy into groups (n = 59) without 36). There no differences (p > 0.05) In endometriosis, there was a significant correlation (r 0.821; p 0.000), but those compartments 0.049; 0.05). Furthermore, found...
The aim of this study was to investigate the relationship between lactoferrin and iron its binding proteins in women with endometriosis by simultaneously measuring these parameters plasma peritoneal fluid. Ninety were evaluated, whom 57 confirmed as having endometriosis. Lactoferrin measured ELISA, transferrin, ferritin on a Cobas 8000 analyser. transferrin fluid lower compared plasma, contrast iron. In showeds associations group without correlated lactoferrin, patients ratio concentration...
Aim: The aim was to measure concentrations of four neutrophil-derived proteins in meconium as biomarkers describing prenatal environment. Methods: Calprotectin, lactoferrin, myeloperoxidase and PMN-elastase were measured using ELISA kits serial portions (n = 81) from 20 healthy neonates. Results. highest concentration for calprotectin (286.5 ± 214.6 µg/g) with a positive correlation (r 0.75, p < 0.0001) (1.81 1.72 µg/g). For (1.70 2.69 negative observed -0.51, 0.0001; r -0.60, 0.0001,...
Alpha-1 antitrypsin (AAT), vitamin-D binding protein (VDBP) and neutrophil granule proteins are specifically related to the function may be considered candidate biomarkers detected measured in meconium (the first feces of newborn infants) as signals indicating abnormal processes fetal stage. Individual found can a source information pertaining intrauterine metabolic processes.Concentrations AAT, VDBP, calprotectin, myeloperoxidase, lactoferrin elastase were using ELISA tests 80 samples...
The lack of specific biological materials and biomarkers limits our knowledge the mechanisms underlying intrauterine regulation iron supply to fetus. Determining meconium content proteins commonly used in laboratory assess transport, storage, distribution body may elucidate their roles fetal development. Ferritin, transferrin, haptoglobin, ceruloplasmin, lactoferrin, myeloperoxidase (MPO), neutrophil gelatinase-associated lipocalin (NGAL), calprotectin were determined by ELISA samples...
Abstract Aim The proteins accumulated in the meconium reflect intrauterine environment and are naturally excreted by a neonate. identification classification of individual may be valuable source information about physiological pathological processes utero . Methods Proteomic analysis was used to study protein composition pooled 50 serial portions from 10 neonates. were classified based on gene ontology database. amounts relative number (%) identified categories their subcategories assessed....
Understanding the pathomechanisms underlying high meconium calprotectin concentrations is key to potential uses of this parameter for assessment intrauterine environment in which fetus develops. The aim study was measure serial portions passed after birth and calculate individual variations total content accumulated during gestation.Calprotectin were measured using Calprotectin ELISA kit (Immundiagnostik AG) all (n = 81) from 20 healthy neonates. For each neonate, calculated, reflecting sum...
Neutrophil gelatinase-associated lipocalin (NGAL) and lactoferrin (Lf) are among the key components of innate immune system due to their ability bind iron with high affinity thus control inflammation. The aim this study was test use NGAL LF measurements in meconium for assessment intrauterine homeostasis. Lf concentrations were measured using ELISA kits all serial portions (n = 81) collected from 20 healthy neonates. Mean ± SD concentration 45.07 78.53 µg/g more than 1000-fold higher...
Abstract Intrauterine environmental factors can be associated with perinatal complications and long-term health outcomes although the underlying mechanisms remain poorly defined. Meconium formed exclusively in utero passed naturally by a neonate may contain proteins which characterise intrauterine environment. The aim of study was proteomic analysis composition meconium their classification biological function. Proteomic techniques combining isoelectrofocussing fractionation LC-MS/MS were...
The molecular mechanisms regulating homeostasis in the developing fetus have not been satisfactorily elucidated. Meconium contains substances accumulated fetal intestines. Measurements of transferrin and ferritin concentrations meconium assessment transferrin–ferritin relationships could enhance knowledge about specific processes intrauterine period involving two proteins their effects on development growth fetus. Transferrin were measured by ELISA homogenates first portions from 125...
Ferritin is an indirect marker for total body iron stores. Comparison of the ferritin concentrations in meconium with proteins regulating metabolism could aid better understanding principles behind adjustment between fetal pool and newborn size. Ferritin, transferrin, haptoglobin, ceruloplasmin, lactoferrin, myeloperoxidase, neutrophil gelatinase-associated lipocalin (NGAL) calprotectin were measured by ELISA samples from 122 neonates. The neonates classified according to tertiles values...
Establishing any characteristic associations between the serum parameters of thyroid function and proteins in pregnancy may aid elucidating role gland regulation pregnancy-specific metabolic processes selecting candidate biomarkers for use their clinical assessment. Concentrations stimulating hormone (TSH), free tri-iodothyronine (fT3) thyroxine (fT4), six electrophoretically separated protein fractions (albumin, alpha-1-, alpha2-, beta-1-, beta-2- gamma-globulins), representative...