A5071262988- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Acute Kidney Injury Research
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Multiple Sclerosis Research Studies
- Autoimmune and Inflammatory Disorders Research
- Immune cells in cancer
- Nutrition and Health Studies
- Neurogenesis and neuroplasticity mechanisms
- Chronic Lymphocytic Leukemia Research
- Intracranial Aneurysms: Treatment and Complications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peripheral Neuropathies and Disorders
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Cerebrovascular and Carotid Artery Diseases
- Kawasaki Disease and Coronary Complications
- Long-Term Effects of COVID-19
- Moyamoya disease diagnosis and treatment
- Endometriosis Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Whipple's Disease and Interleukins
- Galectins and Cancer Biology
- Muscle and Compartmental Disorders
Medical University of Lublin
2018-2025
The most common manifestation of endometriosis, a condition characterized by the presence endometrial-like tissue outside uterus, is endometrioma, cystic ovarian lesion. It commonly occurring associated with chronic pelvic pain exacerbated prior to and during menstruation, as well infertility. exact pathomechanisms endometrioma are still not fully understood. Emerging evidence suggests pivotal role immune dysregulation in pathogenesis endometriomas, primarily influencing both local systemic...
Chronic lymphocytic leukaemia (CLL) is a haematological malignancy primarily affecting older adults, characterised by the proliferation of functionally impaired B lymphocytes with abnormal expression CD5, typical T cell marker. The current study investigates cytotoxicity-related receptors (CD16, CD56, CD57, CD69) and checkpoint (LAG-3) on γδ cells in CLL patients. Sixty-nine treatment-naive patients fourteen healthy controls were recruited. Flow cytometry analysis revealed that had higher...
In the current study, we analysed role and prognostic value of myeloid-derived suppressor cells (MDSC) in chronic lymphocytic leukaemia (CLL). The frequency circulating monocytic MDSC (M-MDSC; defined as CD14+CD11b+CD15-HLA-DR-/low cells) was assessed correlation with clinical laboratory parameters characterising disease activity patient immune status. Samples peripheral blood from untreated CLL patients healthy volunteers were stained monoclonal antibodies for flow cytometry analysis....
Monocytes are one of the least studied immune cells with a potentially important role in pathogenesis chronic lymphocytic leukemia (CLL). Nevertheless, data regarding subpopulations monocytes CLL microenvironment still limited. For very first time, this study presents an assessment monocyte subsets divided according to SLAN and CD16 expression patients. The involved 70 freshly diagnosed patients 35 healthy donors. Using flow cytometry, were assessed among PBMCs. CD14+ can be into:...
Currently, data regarding the impact of COVID-19 disease (caused by SARS-CoV-2) on patients with childhood rheumatic diseases are significantly limited. To assess possible connection, we measured levels IgA and IgG anti-SARS-CoV-2 antibodies in children juvenile idiopathic arthritis (JIA) a control group during pandemic, prior to introduction anti-COVID-19 vaccination. We assessed PD-1 suppressive molecule inflammatory markers correlated those results serological response SARS-CoV-2. In JIA...
The role of programmed death cell protein 1 (PD-1) has already been described in a range various diseases, including COVID-19. This study provides new, innovative data, related to the expression PD-1 and risk Paediatric Inflammatory Multisystem Syndrome, temporally associated with SARS-CoV-2 infection (PIMS-TS)—a rare, but potentially life-threatening complication In this study, we evaluated patients PIMS. Blood samples were taken from at time diagnosis (n = 33), after 6 weeks 3 months 24),...
Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary vascular resistance and right heart failure, with emerging evidence suggesting key role for immune dysregulation in its pathogenesis. This study aimed to assess the involvement of lymphocytes, particularly regulatory T cells (Tregs), expression checkpoint molecules PD-1 PD-L1 on peripheral blood subpopulations patients diagnosed PAH. The involved 25 patients; mononuclear were isolated subsequently...
Interleukin 15 (IL-15) is known to be involved in the pathogenesis of multiple sclerosis (MS). An animal study revealed a distinct subset IL-15-producing γδ T cells that correlate with disease severity. The aim current was test whether such also present humans and its importance for MS. peripheral blood from 29 patients relapsing-remitting MS (including 6 relapses) 22 controls stained monoclonal antibodies analyzed flow cytometry. existence IL-15+ confirmed. Moreover, percentage...
Introduction. PECAM-1 and NKRP1A are both involved in the vascular transmigration of T lymphocytes. Vascular is a crucial process multiple sclerosis pathogenesis. Methods aim. The current paper presents an analysis expression on γδ cells. Expression subsets cells was performed with flow cytometry. Results. Based cytometry data, PECAM1 slightly differentially modulated cells-it up-regulated during relapse, but down-regulated remission. Moreover, significant downregulation CD3 noted from MS...
Introduction: Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of the central nervous system, treatment which remains great challenge for modern medicine. An important part it, apart from slowing down process demyelination, symptomatic sphincteral disorders, spasticity, muscle weakness, visual disturbances, mood, depression and gait impairment, have been carried out with use fampridine short time. Materials Methods: The study uses method literature analysis in form...