Introduction For centuries, various species from the genus Alchemilla have been utilized in traditional medicine worldwide. Among them, vulgaris L. (Rosaceae) stands out as a promising herbal drug candidate due to its phytochemicals displaying anti-inflammatory and antioxidant properties. Methods In our study, we investigated interaction between human gut microbiota lady’s mantle herb extract (AV) following biotransformation of extract’s constituents their impact on colorectal cancer cells...

Abstract Propolis and Bacopa monnieri (L.) Wettst. (Brahmi) are natural products that contain many active substances possess anticancer properties. The aim of this study was to investigate the chemical composition Polish propolis extract (PPE) by gas chromatography-mass spectrometry (GC–MS), B. extracts (BcH, BcS) high performance liquid chromatography with diode array detector mass coupled electrospray ionization (LC–ESI–MS) finally determine its anti-proliferative potential combined BcH...

Helichrysum italicum is a plant traditionally used for skin-related disorders that becoming an increasingly popular ingredient in cosmetic products. In this work, "green" ultrasound-assisted extraction method H. phenolics was developed using skin-friendly cyclodextrins (CDs). Extraction conditions needed the greatest yield of target compounds (total phenolics, phenolic acids, and flavonoids) were calculated. The composition extracts determined LC-MS spectrophotometric methods. Among tested...

In this report, we discuss the effects of undescribed flavone derivatives, HZ4 and SP9, newly isolated from aerial parts Hottonia palustris L. Scleranthus perennis on membranes. Interaction flavonoids with lipid bilayers is important for medicinal applications. The experiments were performed FTIR NMR techniques liposomes prepared DPPC (dipalmitoylphosphatidylcholine) EYPC (egg yolk phosphatidylcholine). data showed that examined polyphenols incorporate into polar head group region...

Various phytochemical studies have revealed that jackfruit (Artocarpusheterophyllus Lam.) is rich in bioactive compounds, including carotenoids, flavonoids, volatile acids, tannins, and lectins. The aim of the study was to analyze biological activity water-soluble polysaccharide (WSP) isolated from assess its immunomodulatory, cytotoxic, anti-oxidative effects on human colon carcinoma cells vitro. neutral red (NR) uptake assay no toxic influence polymer viability tumor (HT29 SW620). After 24...

The effects of different extracts obtained from Jasione montana L. (JM1–JM6) and their main metabolites on biological processes during wound healing were evaluated. effect closure in the scratch test was established, collagen type I synthesis anti-inflammatory assessed by flow cytometry a human dermal fibroblast model (PCS-201-012). Additionally, antioxidant activity (DPPH FRAP) degree inhibition elastase participating proliferation skin fibroblasts determined an vitro model. fractions...

Despite the common use of Potentilla L. species (Rosaceae) as herbal medicines, a number still remain unexplored. Thus, present study is continuation evaluating phytochemical and biological profiles aqueous acetone extracts from selected species. Altogether, 10 were obtained aerial parts P. aurea (PAU7), erecta (PER7), hyparctica (PHY7), megalantha (PME7), nepalensis (PNE7), pensylvanica (PPE7), pulcherrima (PPU7), rigoi (PRI7), thuringiaca (PTH7), leaves fruticosa (PFR7), well underground...

The isolation of phenolics from aerial parts Corispermum marschallii yielded a total 13 compounds including nine previously undescribed patuletin and spinacetin glycosides. These were identified as 3- O-β-d-galactopyranosyl-7- O-β-d-glucopyranoside (1), (2), O-(6″- O-β-d-glucopyranosyl)-β-d-galactopyranoside (3), O-α-l-arabinopyranosyl)-β-d-galactopyranoside (4), O-(2″- O-(5‴- O-α-l-arabinopyranosyl)-β-d-apiofuranosyl)-β-d-galactopyranoside (5), O-β-d-apiofuranosyl)-β-d-galactopyranoside...

Previously, we have revealed that prolonged administration of a polyphenol-rich 0.1% extract from the berries Aronia melanocarpa L. (chokeberries) alone and under chronic exposure to cadmium influences body status zinc (Zn) copper (Cu). The aim this study was evaluate, in an vitro model, chelating properties (0.05% 0.1%) its main polyphenolic ingredients (cyanidin 3-O-β-galactoside, chlorogenic acid, neochlorogenic (+)-catechin, (−)-epicatechin, quercetin, kaempferol) regarding divalent ions...

Jasione montana L. (Campanulaceae) is used in traditional Belarusian herbal medicine for sleep disorders children, but the chemical composition and biological activity have not been investigated. In this study, activities of J. extracts, their fractions main compounds were evaluated amelanotic melanoma C32 (CRL-1585) cells normal fibroblasts (PCS-201-012). The extracts analyzed using liquid chromatography-photodiode array detection-electrospray ionization-mass spectrometry...

Four new compounds, 5-hydroxy-2',6'-dimethoxyflavone (4), 5-hydroxy-2',3',6'-trimethoxyflavone (5), 5-dihydroxy-6-methoxyflavone (6), and 5,6'-dihydroxy-2',3'-dimethoxyflavone (7), three known 1,3-diphenylpropane-1,3-dione (1), 5-hydroxyflavone (2), 5-hydroxy-2'-methoxyflavone (3), were isolated from the aerial parts of Hottonia palustris. Their chemical structures determined through use spectral, spectroscopic crystallographic methods. The quantitative analysis compounds (1-7) zapotin (ZAP)...

The aim of this study was to determine the anti-tumor activity extracts isolated from Potentilla alba L. on human colon cancer cells HT-29 line and non-cancer epithelial CCD 841 CoTr line. research methods we used cytotoxic proliferative properties were 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) neutral red (NR) assays, ability produce nitric oxide, Griess method, biochemical like 2,2-diphenyl-1-picrylhydrazyl (DPPH) ferric reducing antioxidant power (FRAP) indicating...

Rosemary extract (RE) and lemon balm (LBE) attract particular attention of pharmacists due to their high therapeutic potential. Osteogenesis imperfecta (OI) type I is a heritable disease caused by mutations in collagen characterized its reduced amount. The aim the study was evaluate effect extracts rosmarinic acid (RA) on level OI skin fibroblasts. Phytochemical analysis RE LBE carried out liquid chromatography–photodiode array detection–mass spectrometry. expression at transcript protein...

In the present study, hydrogels containing dried extract of tormentil ( Potentilla erecta (L.) Raeusch., Rosaceae) were designed and qualitatively evaluated regarding their viscosity, thixotropy, texture properties. As mucoadhesiveness is a crucial factor determining drug retention within oral cavity, mucoadhesive properties expressed as work adhesion maximum detachment force under presence porcine buccal mucosa two different models layers: mucin gelatin discs evaluated. The fingerprints...

The mixture of three phytosterols (campesterol, stigmasterol and β-sitosterol), β-sitosterol 3-O-glucoside syringin were isolated from hexane methanol extract Cirsium rivulare roots after chromatographic separation. main component the source was which obtained with yield 0.08% dry source. In extract, qualitative quantitative composition fatty acids determined. predominant linoleic acid (23.31 mg/g extract). extracts showed antioxidant activity. ability to scavenge DPPH• free radical in...

Cinquefoils have been widely used in local folk medicine Europe and Asia to manage various gastrointestinal inflammations and/or infections, certain forms of cancer, thyroid gland disorders, wound healing. In the present paper, acetone extracts from aerial parts selected Potentilla species, namely P. alba (PAL7), argentea (PAR7), grandiflora (PGR7), norvegica (PN7), recta (PRE7) , closely related Drymocalis rupestris (syn. ) (PRU7), were analysed for their cytotoxicity antiproliferative...

Comfrey root (Symphytum officinale L., Boraginaceae) has been used in folk medicine for a long time to treat different diseases. It is recommended swellings, phlebitis, contusions, gastro-duodenal ulcers, respiratory diseases, and metrorrhagia. Currently, preparations from S. are only topically due its wound-healing effects, reducing inflammation the treatment of broken bones, tendon damage, painful joints muscles. Although it widespread plant material, little known about interaction...