A5023655441- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- IL-33, ST2, and ILC Pathways
- Parasites and Host Interactions
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
- Energy, Environment, Economic Growth
- Chromatin Remodeling and Cancer
- Cancer Cells and Metastasis
- Drug-Induced Hepatotoxicity and Protection
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Climate Change Policy and Economics
- Systemic Lupus Erythematosus Research
- Mycotoxins in Agriculture and Food
- Vehicle Dynamics and Control Systems
- Vibration Control and Rheological Fluids
- Single-cell and spatial transcriptomics
- Lung Cancer Treatments and Mutations
- Eosinophilic Esophagitis
Guangxi Medical University
2022-2025
Fujian Medical University
2023
Mengchao Hepatobiliary Hospital
2023
University of Florida
2023
Guangxi Hydraulic Power Machinery Research Institute
2022
University of Houston
2021-2022
Guhua Hospital
2022
Cancer Hospital of Chinese Academy of Medical Sciences
2021
University of Chinese Academy of Sciences
2021
Zhejiang Cancer Hospital
2021
The expression and biological role of IL33 in colon cancer is poorly understood. In this study, we show that expressed by vascular endothelial cells tumor the human microenvironment. Administration overexpression murine enhanced cell growth vivo, respectively. stimulated sphere formation prevented chemotherapy-induced apoptosis. Mechanistically, activated core stem genes NANOG, NOTCH3, OCT3/4 via ST2 signaling pathway, induced phosphorylation c-Jun N terminal kinase (JNK) activation binding...
Cancer is a major threat to public health in the 21st century because it one of leading causes death worldwide. The mechanisms carcinogenesis, cancer invasion, and metastasis remain unclear. Thus, development novel approach for detection urgent, real-time monitoring crucial revealing its underlying biological mechanisms. With optical chemical advantages quantum dots (QDs), QD-based nanotechnology helpful constructing biomedical imaging platform behavior study. This review mainly focuses on...
Background Extensive evidence links Clonorchis sinensis ( C . ) to cholangiocarcinoma; however, its association with hepatocellular carcinoma (HCC) is less acknowledged, and the underlying mechanism remains unclear. This study was designed investigate between infection HCC reveal relationship cancer stemness. Methods A comprehensive analysis of 839 patients categorized into (-) (+) groups conducted. Chi-square Mann–Whitney U tests were used assess clinical factors. Kaplan–Meier Cox...
Clonorchis sinensis (C. sinensis) infection is a significant risk factor for hepatocellular carcinoma (HCC), yet its underlying mechanisms remain poorly understood. This study aimed to investigate the impact of C. on serum proteomic and metabolomic profiling HCC patients, focusing potential mechanisms. A retrospective clinical analysis was conducted 1121 comparing those with without infection. The influence proteome metabolome in further assessed. correlated younger age at cancer onset, male...
nuclear-associated antigen Ki67 (Ki67) emerges as a clinically practical biomarker for proliferation assessment among many cancer types. However, the definite prognostic value of against specific type has remained vague. This study aims to perform comprehensive pan-cancer analysis prognosis across various explored expression, value, and tumor-infiltrating immune MKI67 in TCGA database by pan-cancer, then performed immunohistochemical, correlation using 10028 patients top 10 China we...
ABSTRACT Colon cancer (CC) is one of the most common cancers globally, which associated with gut microbiota intimately. In current research, exploring complex interaction between microbiomes and CC a hotspot. However, information on in previous studies based fecal, does not fully display microbial environment CC. Herein, we collected mucosal tissue samples from both tumor normal regions 19 patients clarified composition by 16S rRNA metagenomic sequencing. Additionally, RNA-Seq was also...
Clonorchis sinensis (Cs)-infected hepatocellular carcinoma (HCC) patients have a poorer prognosis than non-Cs-infected HCCs. However, the molecular mechanisms of Cs-infected HCC remain unclear. To address this, this study aims to uncover tumor microenvironment and features that may contribute these poor outcomes. The research involved bulk RNA sequencing paired adjacent tissue samples from 10 Cs + - patients. Differentially expressed genes were identified, followed by enrichment analyses...
Conflicting results have been reported on the association of Pro12Ala polymorphism PPARγ2 gene with risk type 2 diabetes or obesity.A total 3146 subjects 1145 cases and 2001 healthy controls were included in study. Genomic DNA was obtained from blood samples screening for polymorphisms done using an allelic discrimination assay-by-design TaqMan method. Overall, Ala allele frequency 5.6% control 3.9% (P = 0.023). We found a statistically significant carriers greater homoeostasis model...
To investigate the diagnostic value of positron emission tomography (PET)/magnetic resonance imaging (MRI) radiomics in predicting histological classification lung adenocarcinoma and squamous cell carcinoma. PET/MRI clinical data were retrospectively collected from 61 patients with cancer. According to pathological results surgery or fiberscope, divided into two groups, carcinoma group, which set as positive for (40 cases) negative (21 cases). The characteristics most related cancer...
Background Our objective is to develop a predictive model utilizing the ferritin and transferrin ratio (FTR) clinical factors forecast overall survival (OS) in breast cancer (BC) patients. Methods We conducted retrospective analysis of data from 2858 BC patients diagnosed between 2013 2021. Subsequently, cohort underwent random assignment into distinct subsets: training comprising 2002 validation 856 patients, maintaining proportional 7:3. Employing multivariable Cox regression within...
The goal is to discover novel circulating immune complexes (ICx) in the serum of lupus nephritis (LN) as potential biomarkers.Protein A/G magnetic beads or C1q-coated plates were used capture ICx LN, followed by identification immunoglobulin-binding proteins using liquid chromatography and tandem mass spectrometry (LC-MS/MS). Bioinformatic approaches single-cell RNA sequencing (scRNA Seq) databases select candidate markers LN. selected further validated ELISA.A total 300 discovered...
The objective of this study was to investigate the correlation between dual-energy computed tomography (DECT)-based iodine quantitation and fluorine-18 fluorodeoxyglucose (F-FDG) positron emission (PET)/computed (CT) imaging for response evaluation lung cancers treatment.In prospective study, a total 32 pairs DECT F-FDG PET/CT acquired consecutively from 13 patients with primary or metastatic receiving either radiotherapy alone chemoradiotherapy were analyzed. Imaging examinations performed...
This paper examines how financial frictions and policy uncertainty jointly influence firms' investments in pollution abatement. Our data analyses suggest that financially constrained firms are less likely to invest abatement more release toxic pollutants, with this pattern intensified by surrounding future environmental regulations, as measured "close" gubernatorial elections or revealed earnings conference calls. We then develop a general equilibrium model heterogeneous firms, including...
Clonorchis sinensis (C. sinensis) infection plays an important role in the progression of hepatocarcinogenesis. However, its specific HCC remains unclear. This study aimed to investigate whether C. contributes angiogenesis HCC.
Food toxins are a hidden threat that can cause cancer and tremendously impact human health. Therefore, the detection of food in timely manner with high sensitivity is paramount importance for public health safety. However, current methods relatively time-consuming not practical field tests. In present work, we developed novel aptamer-chip-based sample-to-answer biosensor (ACSB) ochratoxin A (OTA) via fluorescence resonance energy transfer (FRET). this system, cyanine 3 (Cy3)-labeled...
Background: Hepatocellular carcinoma (HCC) is one of the most common aggressive malignancies with increasing incidence worldwide. The oncogenic roles transcription factors (TFs) were increasingly recognized in various cancers. This study aimed to develop a predicting signature based on TFs for prognosis and treatment HCC. Methods: Differentially expressed screened from data TCGA-LIHC ICGC-LIRI-JP cohorts. Univariate multivariate Cox regression analyses applied establish TF-based prognostic...
A prospective phase II study showed that Endostar combined with concurrent chemoradiotherapy (CCRT) can improve overall survival (OS) in patients inoperable locally advanced non-small cell lung cancer (NSCLC). This aimed to retrospectively compare the 5-year rates of NSCLC who received a combination and CCRT receiving CCRT.Treatment-naive had long-term follow-up data were included this study. Patients + group treated plus radical CCRT, CCRT. For radiation dose ≥60 Gy, Kaplan-Meier method was...
Accurate prognosis is crucial for improving hepatocellular carcinoma (HCC) patients, clinical management, and outcomes post-liver resection. However, the lack of reliable prognostic indicators poses a significant challenge. This study aimed to develop user-friendly nomogram predict HCC patients' post-resection prognosis.We retrospectively analyzed data from 1091 randomly split into training (n=767) validation (n=324) cohorts. Receiver operating characteristic (ROC) curves determined optimal...
This study aimed to investigate the differentiation state and clinical significance of colorectal cancer cells, as well predict immune response prognosis patients based on differentiation-related genes cancer.Colorectal cells exhibit different states under influence tumor microenvironment, which determines cell fates.We combined single-cell sequencing (scRNA-seq) data from The Cancer Genome Atlas source with extensive transcriptome Gene Expression Omnibus database. We obtained using...
Background Breast cancer (BC) is the most common and prominent deadly disease among women. Predicting BC survival mainly relies on TNM staging, molecular profiling imaging, hampered by subjectivity expenses. This study aimed to establish an economical reliable model using preoperative routine blood tests (RT) data for surveillance strategy management. Methods We examined 2863 patients, dividing them into training validation cohorts (7:3). collected demographic features, pathomics...
<title>Abstract</title> <bold>Background:</bold> nuclear-associated antigen Ki67 (Ki67) emerges as a clinically practical biomarker for proliferation assessment among many cancer types. However, the definite prognostic value of against specific type has remained vague. This study aims to perform comprehensive pan-cancer analysis prognosis across various <bold>Methods:</bold> explored expression, value, and tumor-infiltrating immune MKI67 in TCGA database by pan-cancer, then performed...
Abstract Background : IL-33 is considered to be a multifunctional cytokine with dual functions. However, the clinicopathological and prognostic significance of in cancer patients, especially hepatocellular carcinoma (HCC)，remains controversial. Therefore, we conducted 565 patients HCC 561 healthy controls meta-analysis quantitatively evaluate above problems. Methods We collected blood controls. ELISA was used detect concentration ST2 serum, RT-PCR method levels mRNA content. Meanwhile,...