A5068589946- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Reproductive System and Pregnancy
- Tea Polyphenols and Effects
- RNA Research and Splicing
- Phytochemicals and Antioxidant Activities
- Proteins in Food Systems
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Reproductive Biology and Fertility
- Thyroid Disorders and Treatments
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Plant Diversity and Evolution
- Food composition and properties
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Renal and related cancers
- Ovarian function and disorders
- Circular RNAs in diseases
- Chronic Disease Management Strategies
- Meat and Animal Product Quality
First Affiliated Hospital of Zhengzhou University
2019-2025
Northeast Agricultural University
2022-2024
Shanghai Medical College of Fudan University
2015-2024
Fudan University Shanghai Cancer Center
2020-2024
Qingdao University
2023
Zhejiang Cancer Hospital
2016-2023
Chinese Academy of Sciences
2020-2023
Chinese People's Liberation Army
2015-2021
Southeast University
2017-2021
Shanghai Mental Health Center
2020-2021
Thyroid nodules (TNs) have annual increasing trends worldwide, and large-scale investigations on the prevalence of TNs in Beijing communities not been conducted since introduction salt iodization 1995. We performed a cross-sectional study to determine TNs, their epidemiological characteristics, correlation with lifestyle factors. A total 6324 permanent residents aged 18 years or older (mean age, 52.15 ± 11.58 years) from seven representative were included analyses. Once informed consent was...
<h3>Importance</h3> Most older patients with esophageal cancer cannot complete the standard concurrent chemoradiotherapy (CCRT). An effective and tolerable regimen for is needed. <h3>Objective</h3> To evaluate efficacy toxic effects of CCRT S-1 vs radiotherapy (RT) alone in cancer. <h3>Design, Setting, Participants</h3> A randomized, open-label, phase 3 clinical trial was conducted at 23 Chinese centers between June 1, 2016, August 31, 2018. The study enrolled 298 aged 70 to 85 years....
This research explored the influences of ultrasonic and thermal treatments on structure, functional properties, beany flavor soy protein isolate (SPI). In comparison with traditional treatment, treatment effectively induced structural unfolding exposure hydrophobic groups, which reduced relative content α-helix, increased β-turn, β-sheet random coil, improved solubility, emulsifying foaming properties SPI. Both significantly decreased species contents compounds, such as hexanal,...
Obesity is defined as the excessive accumulation or abnormal distribution of body fat. According to data from World Atlas 2024, increase in prevalence obesity has become a major worldwide health problem adults well among children and adolescents. Although an increasing number drugs have been approved for treatment recent years, many these inevitable side effects which increased demand new safe, accessible effective prompt interest natural products. Berberine (BBR) its metabolites, known...
Melatonin is widely observed in the female reproductive system and regulates trophoblast cell functions, but its effects on embryo implantation underlying mechanisms are not well understood. By constructing an vitro culture model, we found that melatonin enhances migration human mouse cells. It also significantly promoted HTR-8/SVneo proliferation, inhibited apoptosis, enhanced migration, mitigated oxidative damage. Further investigation revealed increased rate of spheroids by promotes...
Abstract In the physiological state, female fertility declines with age, as evidenced by a steady decline in oocyte quantity and quality. Aging of first organ, ovary, is accompanied increased oxidative stress levels causing ovarian reserve follicular atresia. Ferroptosis novel mode programmed cell death discovered recent years involved onset development various diseases. To investigate whether ferroptosis regulates aging, we examined granulosa cells from patients normal reserve, decreased...
Previous studies have shown that long noncoding RNAs (lncRNAs) show a highly tissue- and disease-specific expression pattern they regulate the of neighboring genes. Because lncRNAs been to be secreted into general circulation, may used as diagnostic tools for some diseases. Primary ovarian insufficiency (POI) is disease in which women menstrual cessation before age 40, accompanied by elevated follicle stimulating hormone decreased estrogen levels. In this study, cortical tissues from five...
Thyroid nodule (TN) and goiter are two common disorders of the thyroid. Despite their benign nature, both conditions can be associated with multiple pathologic including thyroid cancer. In this study, we conducted a large-scale epidemiological study in Chinese women to identify risk factors implicated occurrence TN goiter. We analyzed demographic data, lifestyle, medical history, body height, weight, waist circumference, mass index (BMI), blood pressure, serum glucose lipids. addition,...
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is an extracellular matrix that plays important role in the process of ovulation. According to previous studies, expression level ADAMTS1 granulosa cells polycystic ovarian syndrome (PCOS) patients mechanism for regulating oocyte quality embryonic development potential are still unclear. Our research clarified was significantly increased PCOS as compared ovulatory controls. After silencing cells, cell proliferation E...
Abstract Backgrounds Long non-coding RNA is a novel group of non-protein coding transcripts over 200 nt in length. Recent studies have found that they are widely involved many pathological and physiological processes. In our previous study, we lnc-GULP1–2:1 was significantly down-regulated the ovarian cortical tissue patients with primary insufficiency predicted has regulatory effect on COL3A1. Results this mainly localized cytoplasm luteinized granulosa cells. The expression lower...
This study aimed to investigate the aggressive behavior of triple‑negative breast cancer (TNBC) cells that had survived ionizing radiation and explore potential targets TNBC combination treatment. Consistent with previous literature, Axl was highly expressed in closely associated degree malignancy based on immunohistochemical staining. Using a gradient irradiation method, radiation‑resistant mouse cell line 4T‑1/IRR established. It found expression upregulated cells. After by X‑ray,...
In this study, the structure of anthocyanin fractions isolated from black rice (Oryza sativa L.) was modified by enzyme catalysis method using caffeic acid as an acyl donor. At same time, effects acylation on lipophilicity, antioxidant activity, and stability anthocyanins were comprehensively evaluated. The structural analyses acylated derivatives based ultraviolet-visible spectroscopy, Fourier-transform infrared ultra-high-performance liquid chromatography-high-resolution mass spectrometry,...
Abstract Mammalian ovarian follicular development is an intricate, elaborate, and well‐organized phenomenon regulated by various signaling pathways; however, the underlying mechanism remains unclear. sirtuins (sirtuin 1 to sirtuin 7) are a group of NAD + ‐dependent deacetylases implicated in physiological processes including cell proliferation, apoptosis, cycle progression, insulin signaling. have been studied using adult aged bovine, porcine, murine models. However, limited information...
Peripheral inflammation plays a key role in the development of depression-like behaviors. However, mechanisms underlying these effects remain largely unknown. Here, we found that level citrullinated histone H3 (cit-H3) significantly increased plasma wildtype mice treated with lipopolysaccharide (LPS), which indicated neutrophil extracellular traps (NETs) were formed. Moreover, LPS-induced and asocial behaviors alleviated deficient NETs. Mechanistically, NETs formation aggravated peripheral...
To investigate the association between health locus of control and self-management behaviors in patients receiving hemodialysis. Patients hemodialysis Xiamen, Fujian province, from December 2014 to March 2015 answered Chinese version Multidimensional Health Locus Control scale behavior questionnaire. The participants this study indicated that they believed others exerted more over their than themselves or chance. In addition, majority had a medium low level behaviors. Positive correlations...
A prospective phase II study showed that Endostar combined with concurrent chemoradiotherapy (CCRT) can improve overall survival (OS) in patients inoperable locally advanced non-small cell lung cancer (NSCLC). This aimed to retrospectively compare the 5-year rates of NSCLC who received a combination and CCRT receiving CCRT.Treatment-naive had long-term follow-up data were included this study. Patients + group treated plus radical CCRT, CCRT. For radiation dose ≥60 Gy, Kaplan-Meier method was...