A5007350641- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Cholinesterase and Neurodegenerative Diseases
- Pomegranate: compositions and health benefits
- Morinda citrifolia extract uses
- Natural Compounds in Disease Treatment
- Medicinal Plants and Neuroprotection
- Medicinal Plants and Bioactive Compounds
- Bioactive Compounds and Antitumor Agents
- Ginseng Biological Effects and Applications
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Signaling Pathways in Disease
- Plant-based Medicinal Research
- Plant biochemistry and biosynthesis
- Phytochemistry and Bioactivity Studies
- Phytochemical Studies and Bioactivities
- DNA and Nucleic Acid Chemistry
- Curcumin's Biomedical Applications
- Flavonoids in Medical Research
- Phytochemistry and biological activities of Ficus species
Guangdong Pharmaceutical University
2019-2025
University of Toyama
2012-2021
Nagasaki University
2021
University of Kinshasa
2021
Komatsu (Japan)
2021
Minzu University of China
2020
State Administration of Traditional Chinese Medicine of the People's Republic of China
2020
Peking University
2009-2012
Chinese Academy of Medical Sciences & Peking Union Medical College
2007
This study aimed to explore the mechanism of fucoidan in chronic kidney disease (CKD)-triggered cognitive dysfunction. The adenine-induced ICR strain CKD mice model was applied, and RNA-Seq performed for differential gene analysis between aged-CKD normal mice. As a result, (100 200 mg kg
Acetaminophen (APAP) overdose has long been recognized as the main cause of drug-induced liver injury (DILI), characterized by glutathione (GSH) depletion and reactive oxygen species (ROS) accumulation, leading to ferroptosis inflammatory responses. There is an urgent need for liver-protective agents combat ferroptosis, modulate oxidative stress, ameliorate inflammation. Catechin, a well-known polyphenol compound, shown have antioxidant potential. However, its protective role on APAP-induced...
Introduction Sepsis is a life-threatening condition that often leads to organ dysfunction and systemic inflammation, with gut microbiota dysbiosis playing crucial role in its pathogenesis. The of Desulfovibrio vulgaris ( D. ), potentially pathogenic bacterium, sepsis remains unclear. Methods We first assessed the abundance feces septic mice patients using qPCR. Mice were then orally gavaged (2 × 10 8 CFU/mouse/day) for 7 consecutive days followed by cecal ligation puncture (CLP) surgery....
Ellagic acid (EA) is a dietary polyphenol that widely exists in grapes, strawberries, and walnuts. It usually exerts multiple biological activities together with its vivo metabolites called urolithins. EA urolithins had been proposed as natural agents for applying on the early intervention of Alzheimer’s disease (AD). However, neuroprotective effects those small molecules have not confirmed, action mechanism clear. Deposition beta-amyloid (Aβ) protein well documented being involved...
Dried Eleutherococcus senticosus leaves (ESL), also known as Siberian ginseng tea, are beneficial for human neural disorders. Our previous studies showed that the aqueous extract of ESL enhanced memory in mice, and its saponin fraction (ESL-SAP) exhibited promising neuroprotective activities vitro; however, vivo neurally related effect, bioactive material basis, possible mechanism action ESL-SAP have not been investigated. Here, a series learning tests were carried out, results evidenced...
An aqueous extract of Eleutherococcus senticosus leaves exerted a beneficial effect in restoring the neurite outgrowth from Aβ25–35-induced degeneration using an axonal density assay. Subsequent bioassay-guided fractionation afforded seven new oleanane-type triterpene saponins, ezoukoginosides A–G (1–7), along with nine known analogues. The structures 1–7 were elucidated through chemical and spectroscopic approaches, their effects on investigated. results revealed that hydrophilic saponins...
The pharmacological properties of Eleutherococcus senticosus leaf have not been clarified although it is taken as a food item. In this study, the effects water extract leaves on memory function were investigated in normal mice. Oral administration for 17 days significantly enhanced object recognition memory. Compounds absorbed blood and brain after oral detected by LC-MS/MS analyses. Primarily compounds plasma cerebral cortex ciwujianoside C3, eleutheroside M, B, A1. Pure except A1...
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the dose-limiting side effects cancer chemotherapy. Although control CIPN important, it difficult to manage with currently available therapeutic drugs. Therefore, there a need for novel agents treating CIPN. Goshajinkigan (GJG) Kampo formula composed ten crude While GJG has been used treatment CIPN, active constituents and their underlying mechanisms pharmacological are still unknown. Our previous study revealed that repetitive oral...