Diosgenin, a yam-derived compound, was found to facilitate the repair of axonal atrophy and synaptic degeneration improve memory dysfunction in transgenic mouse model Alzheimer’s disease (AD). It also enhance neuronal excitation function even normal mice. We hypothesized that diosgenin, either isolated or an extract, may represent new category cognitive enhancers with essential activities morphologically functionally reinforce networks. This study aimed investigate effects diosgenin-rich yam...

Intrapulmonary arteriovenous (IPAV) shunting has been shown to occur at rest in some subjects breathing a hypoxic gas mixture [fraction of inspired oxygen (FI(O(2))) = 0.12] for brief periods time. In the present study we set out determine if IPAV could be induced all exposed hypoxia 30 min. Twelve (6 women) breathed four levels (FI(O(2)) 0.16, 0.14, 0.12, and 0.10) min each either an ascending or descending order with 15-min normoxic break between bouts. Saline contrast echocardiography was...

The antimicrobial protein gene LJAMP2 is a plant non-specific lipid transfer from motherwort (Leonurus japonicus). In this study, it was introduced into Chinese white poplar (Populus tomentosa Carr.) via Agrobacterium-mediated transformation with neomycin phosphotransferase II conferring kanamycin resistance as selectable marker. A total of 16 lines were obtained, and polymerase chain reaction (PCR) analysis established the stable integration transgenes in genome. Reverse transcription–PCR...

Chimonanthus praecox is a famous traditional flower in China with high ornamental value. It has numerous varieties, yet its classification highly disorganized. The distinctness, uniformity, and stability (DUS) test enables the nomenclature of various species; thus, it can be used to classify varieties. In this study, traits were quantified using an automatic system based on pattern recognition instead manual measurement improve efficiency DUS testing. A total 42 features quantified,...

Concern has been raised that altering the fraction of inspired O₂ (Fi(O₂)) could accelerate or decelerate microbubble dissolution time within pulmonary vasculature and thereby invalidate ability saline contrast echocardiography to detect intrapulmonary arteriovenous shunt in subjects breathing either a low high Fi(O₂). The present study determined whether gaseous component used for affects detection exercise-induced under varying Twelve healthy human (6 men, 6 women) performed three 11-min...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in structural brain changes and memory impairment. We hypothesized that reconstructing neural networks essential for recovery AD. Heat shock cognate 70 (HSC70), member of the heat protein family molecular chaperones, upregulated AD patient brains, recent studies have demonstrated HSC70 facilitates axonal degeneration pathological progression However, direct effects inhibition on development function never been...

Abstract Trigonelline (TGN; 1-methylpyridin-1-ium-3-carboxylate) is a widely distributed alkaloid derived from plants. Since we previously found neurite outgrowth effect of TGN, hypothesised that TGN might help to improve memory deficits. Here, the efficacy in restoring amyloid β (Aβ)-induced axonal degeneration and improving function was investigated Alzheimer’s disease 5XFAD model mice overexpress mutated APP PS1 genes. Exposure Aβ25-35 for 3 days induced atrophy axons dendrites. Post...

Abstract Central nervous system axons have minimal capacity to regenerate in adult brains, hindering memory recovery Alzheimer’s disease (AD). Although recent studies shown that damaged sprouted and AD mouse long-distance axonal re-innervation their targets has not been achieved. We selectively visualized axon-growing neurons the neural circuit for formation, from hippocampus prefrontal cortex, showed successfully extended native projecting area models of (5XFAD) by administration an...

Cardiopulmonary function is reduced in adults born very preterm, but it unknown if this results pulmonary gas exchange efficiency during exercise and, consequently, leads to aerobic capacity subjects with and without bronchopulmonary dysplasia (BPD). We hypothesized that an excessively large alveolar arterial oxygen difference (AaDO2) resulting exercise-induced hypoxemia (EIAH) would contribute fitness preterm BPD. Measurements of function, lung volumes diffusion for carbon monoxide (DLco)...

Abstract Aims This multicenter prospective cohort study (registration no. ChiCTR2000032089) aimed to investigate the relationship between saliva and plasma levetiracetam concentrations determine whether could be used for routine monitoring of during pregnancy. Methods The slot in simultaneously obtained samples were measured using UPLC–MS/MS. correlations dose‐normalized compared among pregnant women different stages nonpregnant control participants with epilepsy. Results In total, 231...

We previously found diosgenin, an herbal drug-derived steroid sapogenin, to be remarkably effective at restoring Aβ-induced axonal degeneration and improving memory function in model of Alzheimer's disease (AD), 5XFAD mouse. In this study, we investigated the downstream signaling diosgenin explored new therapeutic targets AD. showed that expression heat shock cognate (HSC) 70 was increased Aβ-treated neurons mice but decreased by treatment. addition, knockdown HSC70 significantly promoted...

The pharmacological properties of Eleutherococcus senticosus leaf have not been clarified although it is taken as a food item. In this study, the effects water extract leaves on memory function were investigated in normal mice. Oral administration for 17 days significantly enhanced object recognition memory. Compounds absorbed blood and brain after oral detected by LC-MS/MS analyses. Primarily compounds plasma cerebral cortex ciwujianoside C3, eleutheroside M, B, A1. Pure except A1...

Abstract Four young researchers presented their studies in the field of traditional Japanese herbal medicine ( Wakan‐yaku ) at Fourth Annual Young Researcher Forum held day before 2023 annual meeting Japan Society Medical and Pharmaceutical Sciences for Traditional Medicine. Mr Sakoda outlined his research plan, emphasizing potential yokukansan to enhance palliative care cancer patients. Meanwhile, Ms Tanide Nishihara explored correlation among component contents Coptis japonica on Sado...

<title>Abstract</title> <bold>Background</bold><italic> Chimonanthus praecox</italic> is a unique ornamental and economic flowering tree in China, after thousands of years cultivation, it has produced large number varieties rich variety types. <italic>C.praecox</italic> utilizes heterozygous dioecious mating systems that are mainly partially autogamous, thus ensuring the inheritance good genes species, promoting improvement plant varieties. Male sterility widespread plants an important tool...

, a member of the Calycanthaceae family, is unique, traditional, and famous flowering economic tree species in China. Despite existence several varieties, only few cultivars have been formally named. Currently, expression sequence tag-simple repeat (EST-SSR) markers are extensively used to identify different varieties; large number microsatellites can be identified from transcriptome databases. A total 162,638 unigenes were assembled using RNA-seq; 82,778 annotated Nr, Nt, Swiss-Prot, Pfam,...

We previously found that the water extract of Eleutherococcus senticosus leaves (ES extract) enhanced cognitive function in normal mice. Our study also revealed rhizomes Drynaria fortunei (DR memory Alzheimer’s disease model In addition, our previous experiments suggested a combined treatment ES and DR extracts synergistically improved anti-stress response Although those two botanical are expected to be beneficial for neuropsychological function, no clinical data has ever been reported....

Strigolactones (SLs) regulate plant shoot development by inhibiting axillary bud growth and branching. However, the role of SLs in wintersweet (Chimonanthus praecox) branching remains unknown. Here, we identified isolated two genes, CCD7 CCD8, involved SL biosynthetic pathway. Quantitative real-time PCR revealed that CpCCD7 CpCCD8 were down-regulated during When new shoots formed, expression levels almost same as control (un-decapitation). was expressed all tissues, with highest tips roots,...

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Women with epilepsy (WWE) are more likely to develop reproductive endocrine disorders, especially polycystic ovary syndrome (PCOS). This study aimed explore the genetic factors of PCOS in WWE hope improving individual precision diagnosis and treatment. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; registered at West China Hospital between January 2022 October were enrolled this study. Demographic epilepsy-related characteristics recorded,...