A5041159032- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Multiple Sclerosis Research Studies
- Ovarian function and disorders
- Cardiovascular and Diving-Related Complications
- Metabolism and Genetic Disorders
- Polyomavirus and related diseases
- Biochemical Analysis and Sensing Techniques
- Neonatal and fetal brain pathology
- Pregnancy and Medication Impact
- Sleep and Wakefulness Research
- Reproductive System and Pregnancy
- Sleep and related disorders
- Metabolomics and Mass Spectrometry Studies
- Biomedical Text Mining and Ontologies
- Fetal and Pediatric Neurological Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Memory and Neural Mechanisms
- Peripheral Neuropathies and Disorders
- Dementia and Cognitive Impairment Research
- Restless Legs Syndrome Research
- Olfactory and Sensory Function Studies
- Currency Recognition and Detection
- Health, Environment, Cognitive Aging
Sichuan University
2017-2025
West China Hospital of Sichuan University
2017-2025
Army Medical University
2018
Southwest Hospital
2018
Alice Ho Miu Ling Nethersole Hospital
2013
Background Mild cognitive impairment (MCI) is an important prodromal stage of Alzheimer's disease (AD), affecting 69 million individuals worldwide. At present, there a lack community-applicable tool for MCI screening. Exhaled breath volatile organic compounds (VOCs) have been used to distinguish from cognitively normal (CN) only in small sample size studies and the efficacy has not compared with blood biomarkers. Objective This diagnostic study aimed assess feasibility using exhaled VOCs...
Objectives To assess the influence of patent foramen ovale (PFO) on prevalence migraine without aura based propensity score-matched samples in Southwest China. Design Propensity-matched cross-sectional study. Participants Residents over 20 years age were recruited from 15 communities Western China July 2020 to October 2020. A total 3741 residents having accepted undergo contrast-transthoracic echocardiography and a standard structured questionnaire was assessed for relationship between PFO...
Background: Using monitoring devices could help avoid injuries and even death. Currently, wearable sensors such as motion other are used to detect when the patient is having a seizure alarm their caregivers. However, development phase of these requires labor-intensive work on labeling collected data, resulting in difficulties developing devices. Thus, more automated auxiliary method data device seizures for daily use necessary. Methods: We from epileptics outside hospital with our proposed...
Although a growing body of research has indicated strong link between oxidative stress and epilepsy, the exact nature their interaction remains elusive. To elucidate this intricate relationship, we conducted bidirectional Mendelian randomization (MR) analysis employing two independent datasets.
Abstract Objective Closure surgery of patent foramen ovale (PFO) has been found to effectively control cryptogenic stroke and migraine, but it is uncertain whether PFO closure could also alleviate epileptic seizures. This study aims observe the therapeutic effect on Methods Since July 11th, 2017, in neurology department West China Hospital, Sichuan University, Chengdu, we have regularly monitoring patients with epilepsy who undergone closure. The patient's clinical information, such as...
Abstract To assess the risk factors for polycystic ovary syndrome (PCOS) in women with epilepsy (WWE) and develop a practical approach PCOS screening based on clinical characteristic, blood indicator, anti‐seizure medication (ASM) profiles. This cross‐sectional study was conducted 248 WWE who were consecutively enrolled from Epilepsy Center of West China Hospital between April 2021 March 2022. The characteristics, indicators, use ASMs compared without PCOS. Multivariate logistic regression...
Differential diagnosis between epileptic seizures and psychogenic nonepileptic events (PNEEs) is a worldwide problem for neurologists. The present study aims to identify important characteristics from body fluid tests develop diagnostic models based on them.This register-based observational in patients with of epilepsy or PNEEs at West China Hospital Sichuan University. Data 2009 2019 were used as training set. We constructed random forest approach eight subsets divided by sex categories...
<b><i>Introduction:</i></b> Women with epilepsy (WWE) are more likely to develop reproductive endocrine disorders, especially polycystic ovary syndrome (PCOS). This study aimed explore the genetic factors of PCOS in WWE hope improving individual precision diagnosis and treatment. <b><i>Methods:</i></b> registered at West China Hospital between January 2022 October were enrolled this study. Demographic epilepsy-related characteristics recorded,...
To investigate the relationship between right-to-left shunt and migraine to account for unexplained high prevalence of in patients with epilepsy.This is a cross-sectional study. The diagnosis interview process was based on International Classification Headache Disorders-3 beta epilepsy. Participants underwent transthoracic echocardiography (TTE) contrast medium identify shunt. highest number microbubbles were recorded left atrium before complete microbubble outflow right atrium. A...
Epilepsy is a common chronic neurological disease that characterized by spontaneous seizures. It commonly comorbid with behavioral and mood disorders. No studies have yet examined the or structural brain changes associated coriaria lactone (CL)-induced pentylenetetrazol (PTZ)-induced kindlings. This study whether increased seizure susceptibility induced CL/PTZ accompanied impairments aimed to identify changes. Kindling models were using CL PTZ, 10 rats in each group. After successful...
Background: Subjective gastrointestinal complaints have been repeatedly reported in patients with REM sleep behavior disorder (RBD), but objective evidence is scarce. We aimed to objectively investigate the dysfunction individuals probable RBD (pRBD) using an electrogastrogram. Methods: Thirty-two participants pRBD and 60 age- gender-matched healthy controls were enrolled. was diagnosed based on questionnaires further assessed by experienced neurologists. After thorough assessment of...
Backgroundï¼ÂšThe discovery of aquaporin-4 (AQP4) antibody was a major advance since it indicated that neuromyelitis optica (NMO) is an independent disease distinct from multiplesclerosis. Thereafter, broad spectrum disorders in which AQP4 could be found were grouped together and termed as disorder (NMOSD).Recently, scholars have proposed the condition antibody-positivity patients should considered autoimmune channelopathy, NMOSD regarded part. Methods: We describe 41-year-old woman with...
This cross-sectional study sought to evaluate the effectiveness of Montreal Cognitive Assessment (MoCA) and saccade in discerning cognitive function levels among community populations characterized by diverse educational backgrounds.
Abstract Background The effective management of epilepsy in women child-bearing age necessitates a concerted effort from multidisciplinary teams. Nevertheless, there exists an inadequacy the seamless exchange knowledge among healthcare providers within this context. Consequently, it is imperative to enhance availability informatics resources and development decision support tools address issue comprehensively. Materials methods Women with Epilepsy Child-Bearing Age Ontology (WWECA) adhered...
Introduction: In women of childbearing age with epilepsy, 30% experience the comorbidity polycystic ovary syndrome (PCOS), which is marked by a higher prevalence hyperandrogenism. Our recent clinical observations indicate potential contribution hyperandrogenism-induced PCOS to epilepsy susceptibility, and this study aimed unravel underlying factors that increase susceptibility females epilepsy. Methods: A letrozole-induced rat model was employed simulate endogenous The threshold seizure...