A5101569278- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Advanced Radiotherapy Techniques
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced MRI Techniques and Applications
- Mast cells and histamine
- Asthma and respiratory diseases
- Renal and Vascular Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Management of metastatic bone disease
- Cardiac Imaging and Diagnostics
- Urticaria and Related Conditions
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Analysis
Johns Hopkins Medicine
2021-2024
Johns Hopkins University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Handan College
2024
Beijing Hospital
2014-2023
Hunan Normal University
2022
Peking Union Medical College Hospital
2016-2022
Army Medical University
2022
Academia Sinica
2021
Cleveland Clinic
2018-2019
Prior randomized trials have generally shown harm or no benefit of stenting added to medical therapy for patients with symptomatic severe intracranial atherosclerotic stenosis, but it remains uncertain as whether refined patient selection and more experienced surgeons might result in improved outcomes.To compare plus vs alone stenosis.Multicenter, open-label, randomized, outcome assessor-blinded trial conducted at 8 centers China. A total 380 transient ischemic attack nondisabling,...
Background: Extracranial internal carotid artery tortuosity may trigger cerebral ischemia, and body mass index is a measure of based on height weight. The main purpose this study to determine the influence extracranial artery. Methods: A total 926 angiograms were performed in 513 patients, which 116 cases matched controls selected. Arterial was defined as simple tortuosity, kinking, or coiling. severity measured by index, formula: [(actual length/straight-line length−1) ×100]. Results: Body...
Purpose: To investigate the impact of delivery techniques and planning parameters on interplay effect in lung SBRT. Methods: A dynamic virtual patient model containing normal structures a tumor with adjustable sizes, locations, 3D breathing motion was utilized. SBRT plans were developed using both step-and-shoot IMRT VMAT different (energy, isocenter location, PTV margin, dose heterogeneity). 4D doses calculated by simulating synchronized to random initial positions motion. The expected...
Background . Whether carotid tortuosity/kinking of the internal artery leads to cerebral ischemia remains unclear. There is very little research about hemodynamic variation induced by in literature. The objective this study was blood pressure changes tortuosity/kinking. Methods We first created a geometric model Based on boundary conditions, hemodynamics tortuosity and kinking were studied via finite element simulation. Then, an vitro system built validate numerical simulation results. mean...
Purpose Diabetes mellitus indicated poor clinical prognosis for patients with acute ischemic stroke. Furthermore, diabetes could also impact the hemostatic system, while its influence on histological composition of thrombus is unclear. Methods Consecutive retrieved clots were included. Histologic staining included hematoxylin and eosin, Martius Scarlet Blue, immunohistochemistry von Willebrand factor. The differences in clot compared according to history or hyperglycemia (≥7.8 mmol/L)...
Background: The prevalence of intracranial aneurysms is approximately 3% worldwide. Posterior circulation (PC) have a higher risk treatment complications than anterior aneurysms. Improving the survival rate and quality life patients with PC remains one most important issues in field. Objectives: Flow diverter (FD) controversial. We aimed to investigate effects FD analyze differences among different application methods or aneurysm types Design: This multicenter retrospective study. Methods:...
Background: For patients with acute ischemic stroke (AIS), the thrombus density on non-enhanced CT (NECT) indicates composition of thrombus, a characteristic that impacts efficacy mechanical thrombectomy (MT). A previous meta-analysis suggested correlation between higher and successful reperfusion, but some new studies have drawn different conclusions. This single-center study aimed to detect association reperfusion outcomes based various strategies. Methods: We reviewed AIS who underwent MT...
The authors compared the efficacy and cost-effectiveness of middle meningeal artery embolization (MMAE) conventional treatment for chronic subdural hematomas (cSDH).
Background Blood pressure (BP) is a key factor for the clinical outcomes of acute ischemic stroke (AIS) receiving endovascular thrombectomy (EVT). However, effect circadian pattern BP on functional outcome unclear. Methods This multicenter, retrospective, observational study was conducted from 2016 to 2023 at three hospitals in China (ChiCTR2300077202). A total 407 patients who underwent (EVT) and continuous 24-h monitoring were included. Two hundred forty-one cases Beijing Hospital...
Because MRGPRX2 is now recognized as the mast cell receptor for basic secretagogues, there currently a tremendous interest in whether MRGRPX2 could play an important role various pruritic dermatoses such chronic spontaneous urticaria. Therefore, we sought to identify new potent and selective antagonists pharmacologically characterize biological of MRGPRX2.
Kinking of the cervical carotid or vertebral artery is a common structural abnormality in patients with cerebrovascular disease. However, there no consensus about relationship between kinking and ischemic stroke/TIA. We aim to determine effect arterial on
The study aims to enhance the accuracy and practicability of CT image segmentation volume measurement ICH by using deep learning technology. A dataset including brain images clinical data 1,027 patients with spontaneous ICHs treated from January 2010 December 2020 were retrospectively analyzed, a network (AttFocusNet) integrating focus structure attention gate (AG) mechanism is proposed enable automatic, accurate ICHs. In internal validation set, experimental results showed that AttFocusNet...
The aim of this study was to verify the value collateral circulation and B-type natriuretic peptide (BNP) in predicting clinical outcomes patients with acute ischemic stroke (AIS) their biomarker for subtypes before endovascular treatment (EVT).In retrospective study, 182 who underwent EVT unilateral anterior large-vessel occlusion between March 2016 January 2022 were analyzed. modified scoring system on four-dimensional computed tomography angiography (4D CTA-CS) used assess status,...
Vulnerable carotid atherosclerotic plaque (CAP) significantly contributes to ischemic stroke. Neovascularization within plaques is an emerging biomarker linked vulnerability that can be detected using contrast-enhanced ultrasound (CEUS). Computed tomography angiography (CTA) a common method used in clinical cerebrovascular assessments employed evaluate the of CAPs. Radiomics technique automatically extracts radiomic features from images. This study aimed identify associated with...
Background The effect of penicillin therapy on clinical outcomes vary among patients with general paresis ( GP ). We sought to explore biomarkers that might serve as predictors in and identify requiring early intervention. Methods Thirty‐five inpatients were recruited. Each patient underwent comprehensive neuropsychological, neuroimaging laboratory assessments before receiving therapy, returned for follow‐up evaluations after 6 months. visual rating medial temporal lobe atrophy MTA ) the...
Background End-to-end, end-to-side, and side-to-side microvascular anastomoses are the main types of vascular bypass grafting used in microsurgery neurosurgery. Currently, there has been no animal model available for practicing all three one operation. The aim this study was to develop a novel that utilizes rat abdominal aorta (AA), common iliac arteries (CIAs), median sacral artery (MSA) these anastomosis. Methods Eight adult Sprague–Dawley rats were anesthetized then laparotomized. AA,...