A5090469974- Sphingolipid Metabolism and Signaling
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Mast cells and histamine
- Drug Transport and Resistance Mechanisms
- Dermatology and Skin Diseases
- Liver Diseases and Immunity
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Natural Compounds
- Reproductive Physiology in Livestock
- Toxin Mechanisms and Immunotoxins
- Reproductive tract infections research
- Ginseng Biological Effects and Applications
- Inflammasome and immune disorders
- HIV Research and Treatment
- Ferrocene Chemistry and Applications
- Milk Quality and Mastitis in Dairy Cows
- Psoriasis: Treatment and Pathogenesis
- Ion Channels and Receptors
- Pregnancy and Medication Impact
- Metal complexes synthesis and properties
- Hops Chemistry and Applications
- Research on Leishmaniasis Studies
- Liver Disease Diagnosis and Treatment
- Chromatography in Natural Products
University Hospital Regensburg
2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
1988-2025
German Cancer Research Center
2025
Helmholtz Institute Mainz
2025
University Hospital Heidelberg
2025
Johannes Gutenberg University Mainz
2016-2025
Heidelberg University
2025
Universitätsklinikum Erlangen
2021-2022
Leibniz Institute of Plant Biochemistry
2018-2022
Helmholtz Zentrum München
2019
ABSTRACT Human immunodeficiency viruses in 321 samples from tenofovir-naïve patients were retrospectively evaluated for resistance to this nucleotide analogue. All virus strains with insertions between amino acids 67 and 70 of the reverse transcriptase ( n = 6) highly resistant. Virus Q151M mutation divided into susceptible 12) resistant 8) viruses. This difference was due absence or presence K65R mutation, which confirmed by site-directed mutagenesis. Viral clones various combinations...
Abstract The MAS-related G protein-coupled receptor-X2 (MRGPRX2), an orphan receptor expressed on mast cells (MCs), is upregulated upon inflammation and induces hypersensitivity inflammatory diseases. In contrast to the large number of MRGPRX2 agonists, only a few antagonists have been described, no optimization has reported improve potency, selectivity, drug-like properties. Antagonists with ancillary inhibition putative mouse ortholog MRGPRB2 not described. Here, we present...
Abstract Pruritus is a common and disabling symptom in patients with hepatobiliary disorders, particularly those cholestatic features. Serum levels of lysophosphatidic acid (LPA) its forming enzyme autotaxin were increased suffering from hepatic pruritus, correlated itch severity response to treatment. Here we show that culture dorsal root ganglia LPA 18:1 surprisingly activated large fraction satellite glia cells, responses inversely neuronal expressed transient receptor potential channels....
Breast cancer is the most common malignancy in women affecting one out of eight females throughout their lives. Autotaxin (ATX) upregulated breast which results increased lysophosphatidic acid (LPA) formation within tumor. This study's aim was to identify role different mammary cell populations ATX-LPA axis.Epithelial-cell-adhesion-molecule-positive (EpCAM) and -negative cells from tumors, adipose-derived stem (ADSCs) tumor-adjacent tumor-distant fat were isolated compared healthy ADSCs,...
Abstract Previous studies provide high evidence that autotaxin (ATX)-lysophosphatidic acid (LPA) signaling through LPA receptors (LPAR) plays an important role in breast cancer initiation, progression, and invasion. However, its specific different cell lines remains to be fully elucidated offer improvements targeted therapies. Within this study, we analyzed vitro the effect of 18:1 LPAR1, LPAR3 (and LPAR2) inhibitor Ki16425 on cellular functions human (MDA-MB-231, MDA-MB-468, MCF-7, BT-474,...
Intracellular persistence of Chlamydia trachomatis has been implicated in the development chronic infection that can result pelvic inflammatory disease and tubal sterility. By inhibition host cell apoptosis, chlamydiae have evolved a strategy to maintain intracellular environment for replication persistence. Both antiapoptotic cell-derived factors chlamydial protease-like activity factor (CPAF) are involved Chlamydia-mediated apoptosis resistance. Here, we show HeLa cells infected with gamma...
In this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). loaded with different quantities EO (SBA-15|EO1⁻SBA-15|EO5: 8⁻36%) and characterized by traditional methods. Several parameters (stabilities) in vitro behavior on tumor cell lines (melanoma A375, B16 B16F10) were investigated. suppresses release extremely acidic milieu, pointing out that will not be discharged stomach. Furthermore, protects from photodecomposition....
Abstract Acute pruritus occurs in various disorders. Despite severe repercussions on quality of life treatment options remain limited. Voltage-gated sodium channels (Na V ) are indispensable for transformation and propagation sensory signals implicating them as drug targets. Here, Na 1.7, 1.8 1.9 were compared their contribution to itch by analysing -specific knockout mice. was induced a comprehensive panel pruritogens (C48/80, endothelin, 5-HT, chloroquine, histamine, lysophosphatidic acid,...
Hormone receptor (HR) status has become an established target in treatment strategies of breast cancer. Population-based estimates contralateral cancer (CBC) incidence by HR subtype particular are limited. The aim this study was to provide detailed data on CBC for Germany. Invasive were extracted 49,804 women yielding 594 second primaries from the registries Federal States Brandenburg and Saarland area Munich period 1998 2007. Multiple imputation used missing values status. We estimated...
Background: Chronic pruritus affects up to 70% of patients with immune-mediated hepatobiliary disorders. Antagonists the μ-opioid receptor (MOR) and agonists κ-opioid (KOR) are used treat hepatic itch, albeit limited success. An imbalance between ligands MOR KOR receptors has recently been suggested as a potential mechanism pruritus. In this study, we therefore investigated systemic levels important endogenous opioids such β-endorphin, dynorphin A, Leu- Met-enkephalin in plasma large cohort...
Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol characterized by standard analytical methods. The anticancer potential XN IXN into SBA-15 has evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated containing xanthohumol,...
Infection of cattle with chlamydiae is ubiquitous and, even in the absence clinical sequeleae, has a quantifiable negative impact on livestock productivity. Despite recent progress, our knowledge about immune response mechanisms capable counteracting infection and preventing its detrimental effects still limited. A well-established model bovine acute respiratory Chlamydia (C.) psittaci was used here to characterize kinetics local systemic reactions calves. In course two weeks following...
Triphenyltin(IV) compounds with naphthoquinone derivatives containing N-acetylcysteine, N-acetyl-S-(1,2-dion-4-naphthyl)cysteine (1,2-NQC), 1, and N-acetyl-S-(1,4-dion-2-naphthyl)cysteine (1,4-NQC), 2, were synthesized characterized by elemental microanalysis, IR, multinuclear (1H, 13C, 119Sn) NMR spectroscopy as well HR-ESI mass spectrometry. With the aim of in vitro anticancer activity determination ligand precursors novel organotin(IV) against human cervix adenocarcinoma (HeLa), colon...
For efficient cardiovascular risk protection antihypertensive treatment is often combined with cholesterol-lowering treatment, although solid data of interaction and side effects are missing. This a prospective, single-center study conducted in fixed sequence design at steady state candesartan, amlodipine, atorvastatin. Five-day monotherapy candesartan 8 mg was followed by 5-day atorvastatin 40 subsequently 9-day amlodipine 5 monotherapy; each separated washout phases. Immediately after...