A5102945678- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Mobile Health and mHealth Applications
- Breastfeeding Practices and Influences
- interferon and immune responses
- Cancer-related Molecular Pathways
- Neuroblastoma Research and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Medical Research and Treatments
- Cannabis and Cannabinoid Research
- Health Literacy and Information Accessibility
- Bauxite Residue and Utilization
- Aortic aneurysm repair treatments
- Ethics in medical practice
- Advanced Glycation End Products research
- Patient Dignity and Privacy
- Thyroid Disorders and Treatments
- Head and Neck Anomalies
Chinese Research Academy of Environmental Sciences
2025
Qingdao University of Technology
2025
Qingdao University of Science and Technology
2025
Guangzhou Medical University
2011-2023
Second Affiliated Hospital of Guangzhou Medical University
2009-2023
Monash University
2019-2020
The University of Sydney
2019
Third Affiliated Hospital of Guangzhou Medical University
2017
Lishui Central Hospital
2012
Prior randomized trials have generally shown harm or no benefit of stenting added to medical therapy for patients with symptomatic severe intracranial atherosclerotic stenosis, but it remains uncertain as whether refined patient selection and more experienced surgeons might result in improved outcomes.To compare plus vs alone stenosis.Multicenter, open-label, randomized, outcome assessor-blinded trial conducted at 8 centers China. A total 380 transient ischemic attack nondisabling,...
<h3>BACKGROUND AND PURPOSE:</h3> Although flow diverters have been reported with favorable clinical and angiographic outcomes in various literatures, randomized trials determining their true effectiveness safety are still lack. The Parent Artery Reconstruction for Large or Giant Cerebral Aneurysms Using the Tubridge Flow Diverter (PARAT) trial was designed to evaluate efficacy of diverter treatment large giant aneurysms comparison Enterprise stent-assisted coiling. <h3>MATERIALS...
<h3>BACKGROUND AND PURPOSE:</h3> On the basis of high 1-month stroke and/or death (14.7%) rates associated with stent placement in Stenting versus Aggressive Medical Management for Preventing Recurrent Stroke Intracranial Stenosis trial, modifications patient selection and procedural aspects intracranial have been recommended. We performed a multicenter prospective single-arm trial to determine whether such would result lower periprocedural death. <h3>MATERIALS METHODS:</h3> The study...
Background Patients with symptomatic stenosis of intradural arteries are at high risk for subsequent stroke. Since the SAMMPRIS trial, stenting is no longer recommended as primary treatment; however, results this its inclusion criteria and center selection received significant criticism did not appear to reflect our experience regarding natural history nor treatment complications rate. As intracranial atherosclerosis (ICAS) most common cause stroke in Asian countries, we hereby proposing a...
Abstract With the growth of industrial aluminum smelting sector, and increasing proportion incineration treatment in field waste management disposal, there has been a corresponding increase production secondary dross (SAD) municipal solid fly ash (MSWIFA) annually. In this research, ceramsite is prepared using SAD, MSWIFA, bottom (MSWIBA) as raw materials. This study explores impact various factors on mechanical properties their mechanisms under different conditions, including sintering...
Activator protein 1 (AP-1) is a transcriptional factor composed of the dimeric members bZIP proteins, which are frequently deregulated in human cancer cells. In this study, we aimed to identify an oncogenic AP-1 dimer critical for proliferation neuroblastoma cells and investigate whether histone deacetylase inhibitors (HDACIs), new generation anticancer agents, could target dimer. We report here that HDACIs including trichostatin A, suberoylanilidehydroxamic acid, valproic acid M344 can...
Background A recent trial failed to show any benefit of stenting plus medical therapy over alone in patients with symptomatic intracranial stenosis. We aimed examine whether the qualifying artery modifies effect therapy. Methods This is a post-hoc analysis CASSISS that included stenosis, randomly assigned undergo or alone; 358/380 were included. Multivariable logistic regression was used an interaction term estimate altered treatment by artery. The primary outcome composite stroke death...
Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown. Clinical Registration Trial Intracranial Stenting Patients with Symptomatic Artery Stenosis (CRTICAS) was prospective, multicentre, registry designed to assess these and the impact centre experience. Methods 1140 severe, symptomatic arterial (ICAS) patients treated were included from 26 centres, further divided into three groups according annual volume...
Background: Patients with symptomatic stenosis of intracranial arteries are at high risk for future stroke. Since the SAMMPRIS trial, stenting is not recommended as primary treatment; however, results this its inclusion criteria and center selection received significant criticism did appear to reflect our experience regarding treatment complications rate. As atherosclerosis (ICAS) most common cause stroke in Asian countries, we propose a refined prospective, randomised, multicenter study...
Objective To investigate the mechanism of histone deacetylase inhibitors in proliferation glioma cells. Methods (1) Glioma cell line U251 was cultured vitro and treated with Trichostatin A (TSA) at 0.1, 0.2, 0.5, 1.0 or 2.0 μmol/L for 48 h to determine IC50 TSA, then, cells were TSA concentration (0.5 μmol/L) 8, 16, 24, h; 1 M344, 0.5 LBH589, 6 mmol/L NaBu VPA used treat same volume solvent given as control group; MTT assay performed viability. (2) Western blotting test Jun N-terminal...
Purpose: Based on the results of SAMMPRIS trial, modifications in patient selection and procedural aspects for intracranial stent placement have been recommended. We performed a multicenter prospective single arm trial to determine if such will result lower rates peri-procedural stroke and/or death. Materials Methods: The study enrolled patients with recent transient ischemic attack or (excluding lacunar events) related high-grade (70-99% severity) stenosis major artery. Patients were...
Objective To investigate the roles ofc-Jun/Fral dimer in viability of dopaminergic neurons. Methods （1） Dopaminergic neuron-like cell line SH-SYSY was cultured vitro. Cells were lysed for immunoprecipitation to determine whether c-Jun dimerized with Fral. （2） received treatments divided into four groups： Jun N-terminal kinase （JNK） inhibitor SP600125 treatment group, mitogen-activated （MEK） 1/2 U0126 SP600125＋U0126 group and control （treated dimethyl sulfoxide [DMSO]）. Western blotting...
Objective To analyze the clinical diagnosis,treatment and prognosis of rhabdoid meningioma.Methods Two cases meningioma treated in our department were analyzed retrospectively,and relevant literatures reviewed.Results Both two patients underwent complete removal under microscope(Simpson grade I)without postoperative radiotherapy or chemotherapy.The followed up for 2 months years.One patient experienced recurred years after operative,and died due to refusal a second operation.The other...
Objective To investigate the clinical and neuroimaging features microsurgical approaches of intracranial cavernous angiomas (CA). Methods The mierosurgical were analyzed retrospectively in 189 cases CA. Results Of cases, 183 presented with CA cerebral parenchyma manifestations including predominantly headache, epilepsy, hemorrhage, managed by radical resection other 6 showed middle cranial fossa, for which was performed 5 biopsy 1 case. Conclusion Microsurgeries are safe effective treatment...
Objective To explore the vascular architecture features of cerebral arteriovenous malformations (AVMs) and discuss application Onyx for endovascular embolization. Methods Twenty-six patients with AVMs treated in our department from March 2005 to December 2006 were enrolled this study. Based on angioarchitecture hindbrain identified by angiography ultraselective angiography, was used embolizations AVMs. Results Prior embolization Onyx, segmentation, number draining veins, presence open...
Objective To explore the pathogenic bacterium，medicamentum susceptibilitv and information of drug fast which were in trouble with nosocomial infection lung comatose patients dued to cerebral hemorrhage tracheotomy．Methods The informations sputum bacterial culture medicamentum susceptibility retrospective analyzed 56 Datients coma tracheotomy during 2006～2008．Resuits In 112 tests among cases，the positive 102，positive rate was 91．07％,and 126 strains bacterium cultured．Among bacterium，Gram...