A5108132678- Thyroid Disorders and Treatments
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Hemodynamic Monitoring and Therapy
- Lymphoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Glycosylation and Glycoproteins Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Eosinophilic Disorders and Syndromes
- Vascular Malformations Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Protein purification and stability
- Atherosclerosis and Cardiovascular Diseases
- Management of metastatic bone disease
- Pharmacological Effects of Natural Compounds
- vaccines and immunoinformatics approaches
- Sulfur Compounds in Biology
- Radiation Effects in Electronics
Peking University First Hospital
2010-2024
Peking University
2010-2024
Xidian University
2024
Huazhong University of Science and Technology
2024
Union Hospital
2024
Sichuan University
2021
West China Hospital of Sichuan University
2021
Yantai Institute of Coastal Zone Research
2020
University of Chinese Academy of Sciences
2020
Hebei Medical University
2016
Hashimoto's thyroiditis (HT) can be divided into IgG4-positive and IgG4-negative HT. The potential association between HT papillary thyroid carcinoma (PTC) remains poorly understood.The aim was to investigate the relationship PTC compare prognostic parameters of patients with without HT.This a retrospective study.A total 66 (18 HT-alone, 48 PTC) serum samples stored before operation were collected. Another 18 PTC-alone collected as controls.Expression IgG4, IgG, TGF-β1 in tissues levels TgAb...
Graves’ disease (GD) is a common autoimmune disorder with an elevation in pathogenic autoantibodies, specifically anti-thyrotropin receptor antibodies (TRAbs), which are secreted by autoreactive B cells. To date, there has been little research on self-reactive cells GD. In the current study, we reported that unique B-cell subset, CD11c + cells, was expanded peripheral blood (PB) of GD patients, as detected flow cytometry. The frequency positively correlated serum TRAb levels. cytometry data...
A 17-year-old girl presented with a rare case of parasitic rachipagus conjoined twins associated spina bifida, diplomyelia, scoliosis, tethered cord syndrome, and ventricular septal defect. Physical examination found well developed breast an apophysis on the back patient, neuroimaging demonstrated bifida from T8 to L5, butterfly-shaped vertebra T6, abnormal bone behind T7, cord. Successful surgical excision mass was performed. Histological discovered uterine tube, Muller's duct, bone,...
Introduction . Transient global amnesia (TGA) following angiography is rare, and the pathogenesis has not been illustrated clearly till now. The aim of this research to explore TGA by analyzing our data reviewing literature. Methods We retrospectively studied 20836 cases with in hospital between 2007 2015 found 9 angiography. these were analyzed. Results all neural (5 4360) or cardiac (4 8817) no case peripheral (0 7659). Statistical difference was when comparing group (<mml:math...
Objective: One mechanism of hypothyroidism involves the disruption thyroid hormone synthesis and secretion by thyrocytes. Hydrogen sulfide (H2S), as a gas signaling molecule, participates in many physiopathologic processes upregulating sirtuin-1 (SIRT1). The aim current study was to explore whether H2S promotes hormones SIRT1. Methods: Real-time PCR immunohistochemistry were used detect mRNA protein expression H2S-generating enzymes normal human tissues. Serum concentrations from hypothyroid...
Severe and critical coronavirus pneumonia 2019 (COVID-19) often occurs in elder patients with multiple comorbidities, severe hypoxemia events constitute a key factor for the deterioration of some cases. The type COVID-19 could progress into acute respiratory distress syndrome multi-organ dysfunction, which are major causes death. Early non-invasive ventilation (NIV) treatment possible pathophysiological abnormalities is helpful to improve prognosis. Close monitoring oxygenation, reducing...
Background Subclinical hypothyroidism (SCH) brain structure and resting state of functional activity have remained unexplored. Purpose To investigate gray matter volume (GMV) regional with the fractional amplitude low-frequency fluctuations (fALFF) in subclinical patients before after treatment. Material Methods We enrolled 54 SCH 41 age-, sex-, education-matched controls. GMV fALFF were compared controls between pre- post-treatment within group. Correlations thyroid function status mood...
Extensive research has explored the role of aldosterone in insulin resistance. Recent evidence suggests that mineralocorticoid receptor (MR) mediates aldosterone-induced dysregulation cytokines, and most this focused on adjustments fat tissue adipocytes. However, direct effect MR blockade resistance cardiomyocytes remains largely unknown. In present study, we investigated whether improves insulin-sensitizing factors insulin-resistant rats attenuates aldosterone-related transport adiponectin...
Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown. Clinical Registration Trial Intracranial Stenting Patients with Symptomatic Artery Stenosis (CRTICAS) was prospective, multicentre, registry designed to assess these and the impact centre experience. Methods 1140 severe, symptomatic arterial (ICAS) patients treated were included from 26 centres, further divided into three groups according annual volume...
Summary Background Hashimoto's thyroiditis ( HT ) with serum IgG4 concentrations greater than 135 mg/dL can be diagnosed as elevated . also classified into and non‐IgG4 based on an immunohistochemistry analysis of IgG4. The aim our study was to determine the relationship between Method Both thyroid tissues samples stored before pathological examination from 93 patients were collected. levels IgG, IgG4, TgAb TPOA b IgG measured by ELISA s. expression TGF ‐β1 in detected immunohistochemistry....
In clinical practice, serum electrolytes of patients with hyperthyroidism are often ignored. The prevalence hypercalcemia in thyrotoxicosis was 17% to 50% literatures,1,2 and asymptomatic calcium elevation has been documented up 20%.1 We described a case related thyrotoxicosis, which had neglected by the doctors at first visit. A 35-year old man admitted Peking University First Hospital on September 14, 2009 due hypercalcemia. He three-week history palpitation, diaphoresis weight loss,...
Hashimoto's thyroiditis (HT) can be divided into IgG4 HT and non-IgG4 based on IgG immunohistochemical staining. In clinical practice, it is often necessary to identify diseases such as primary thyroid lymphoma (PTL) when a patient presents with rapidly enlarged thyroid. The aim of our study was uncover the differential points between two diseases.
Abstract Background Iron overload plays an important role in hydrocephalus development following intraventricular hemorrhage (IVH). Aquaporin 4 (AQP4) participates the balance of cerebrospinal fluid secretion and absorption. The current study investigated AQP4 formation caused by iron after IVH. Methods There were three parts to this study. First, Sprague–Dawley rats received injection 100 µl autologous blood or saline control. Second, had IVH treated with deferoxamine (DFX), chelator,...
Multiple myeloma (MM) is a malignant plasma cell disorder affecting mainly the elderly population. Revolutionary progress in immunotherapy has been made recently, including monoclonal antibodies and chimeric antigen receptor T (CAR-T) therapies; however, high relapse rate remains problematic. Therefore, combination therapies against different targets would be reasonable strategy. In this study, we present new X-chromosome encoded testis-cancer (CTA) AKAP4 as potential target for MM....
Phosphatase-catalyzed hydrolysis of organic phosphorus is an important pathway for providing bioavailable to aquatic organisms.In this paper, a eutrophic water body was used investigate how and heavy metal ions affect alkaline phosphatase activity (APA) its kinetic properties.The results show that phosphate (PO 4 3-), hexametaphosphate ((PO 3 ) 6 6-), pyrophosphate (P 2 O 7 4-), β-glycerophosphate (C H P 2-) inhibit APA the inhibition effects increased with increasing concentration at range...
Abstract Disclosure: Z. Zhu: None. Y. Huang: Cao: L. Zhang: D. Wang: S. J. Gao: Background The detection of thyroid indicators is high demand in clinical and epidemiological screenings. Compared with existing venous blood tests, peripheral fingertip tests are less invasive have a lower collection volume, which the basis for point-of-care indicators. Objective To explore feasibility minimally micro disease (TD) patients by evaluating consistency TD diagnostic efficiency between tests. Method...
Abstract Disclosure: Z. Zhu: None. Y. Huang: Cao: L. Zhang: D. Wang: S. J. Gao: Background: The detection of thyroid indicators is high demand in clinical and epidemiological screenings. Compared with existing venous blood tests, peripheral fingertip tests are less invasive have a lower collection volume, which the basis for point-of-care indicators. Objective To explore feasibility minimally micro disease (TD) patients by evaluating consistency TD diagnostic efficiency between tests. Method...