Ziguang Yan

ORCID: 0000-0003-0464-7525
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Research Areas
  • Peripheral Artery Disease Management
  • Cerebrovascular and Carotid Artery Diseases
  • Renal and Vascular Pathologies
  • Angiogenesis and VEGF in Cancer
  • Abdominal vascular conditions and treatments
  • Hematopoietic Stem Cell Transplantation
  • Acute Ischemic Stroke Management
  • Intracranial Aneurysms: Treatment and Complications
  • Acute Myeloid Leukemia Research
  • Cardiovascular Health and Disease Prevention
  • Vasculitis and related conditions
  • Aortic aneurysm repair treatments
  • Vascular Procedures and Complications
  • Liver Disease Diagnosis and Treatment
  • Lymphatic System and Diseases
  • Lipid metabolism and disorders
  • Mesenchymal stem cell research
  • Tuberous Sclerosis Complex Research
  • Cancer-related molecular mechanisms research
  • Coronary Interventions and Diagnostics
  • Aortic Thrombus and Embolism
  • State Capitalism and Financial Governance
  • Vascular Anomalies and Treatments
  • Neuroendocrine Tumor Research Advances
  • Pediatric Urology and Nephrology Studies

Shenzhen Second People's Hospital
2025

Shantou University
2025

Shantou University Medical College
2025

Peking University First Hospital
2014-2024

Peking University
2014-2024

Xuzhou Medical College
2008-2024

Qinghai Provincial Peoples Hospital
2023

Affiliated Hospital of Xuzhou Medical College
2010-2013

Crohn's disease (CD) and peripheral arterial (PAD) are closely related. The pathophysiological mechanisms underlying the coexistence of CD PAD unknown. aim this study was to investigate key molecules pathways mediating co-occurrence through quantitative bioinformatic analysis a public RNA sequencing database.Datasets (GSE111889) (GSE120642) were downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) analyzed using 'edgeR' 'limma' packages R. Ontology...

10.3389/fimmu.2022.896645 article EN cc-by Frontiers in Immunology 2022-06-20

Abstract Background Mesenchymal stem cells (MSCs) can improve limb perfusion and increase vessel density in a murine model of hindlimb ischemia. But low engraftment rate those limited their therapeutic effect. Endothelial (ECs) play an important role neovascularization. And MSCs differentiate into ECs vitro. The aim this study is to investigate if EC differentiation vitro before transplantation effective improving outcomes the treatment ischemic disease ischemia animal model. Methods were...

10.1186/s13287-020-01710-x article EN cc-by Stem Cell Research & Therapy 2020-06-08

We report a rare case of rhabdoid meningioma (RM) originating from the optic nerve in 57‐year‐old female. The tumor exhibited or epithelioid histology and harbored BAP1 inactivation mutations. Optic typically originates outer meningeal cells within canal is usually benign, with most cases classified as meningothelial transitional meningiomas. This first reported RM involving nerve, presenting World Health Organization (WHO) central nervous system (CNS) grade 1 histological features but...

10.1111/neup.13028 article EN Neuropathology 2025-01-26

*BACKGROUND: Different lipids and lipoproteins have different relationships with atherosclerotic disease. We did Mendelian randomization study to explore the between them. METHODS: conducted this (MR) analyze causal relationship TG levels/TG total ratio in lipoprotein subfractions Coronary revascularization. RESULTS: The of chylomicrons(CM) extremely large VLDL(P=2.43e-03, OR: 0.53, 95% CI: 0.36-0.80), very VLDL(P=7.94e-04, 0.68, 95%CI: 0.55-0.85), VLDL(P=4.01e-06,OR:0.53,95%CI:0.41-0.69),...

10.1101/2025.04.28.25326612 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2025-05-01

Objective To evaluate the long-term efficacy and safety of selective arterial embolization (SAE) in treatment renal angiomyolipomas (AMLs). Methods This was a retrospective review medical records imaging findings from patients with AMLs who attended our clinic received SAE between January 2007 2014. Only patents complete records, preoperative computed tomography scans using typical follow-up data were included. Results A total 79 enrolled study. Technical clinical success rates 100% 91% ( n...

10.1177/0300060516684251 article EN cc-by-nc Journal of International Medical Research 2017-01-30

Background: Renovascular disease underlies 5–10% of all childhood hypertension. We evaluated the long-term outcomes percutaneous transluminal renal angioplasty (PTRA) for pediatric renovascular hypertension (RVH).

10.21037/tp-23-215 article EN Translational Pediatrics 2023-08-01

Rationale: Renal aneurysm is a rare disease with the atypical symptoms and mostly diagnosed by imaging modalities. Endovascular therapy one of treatment methods. Patient concerns: A retrospective analysis 32 patients renal artery aneurysm, from June 2010 to May 2016 in our hospital, was made study. All them underwent therapy, effects perioperative characteristics it were analyzed. Diagnosis: taken contrast-enhanced CT diuretic dynamic evaluate state illness. Interventions: The preoperative...

10.1097/md.0000000000008615 article EN cc-by-nc Medicine 2017-11-01

Open surgery is the gold standard for treatment of aortoiliac occlusive disease (AIOD). Endovascular therapy has emerged as an attractive alternative AIOD due to its minimal invasiveness. The aims present study were investigate long-term patency endovascular and compare outcomes Transatlantic Inter-Society Consensus II (TASC II) A/B C/D lesions.Patients with (n=156) enrolled in this retrospective cohort study. Patency rates assessed at 12, 36, 60 months after procedure. Parameters...

10.21037/qims-20-599 article EN Quantitative Imaging in Medicine and Surgery 2021-01-27

Abstract Background Iron overload plays an important role in hydrocephalus development following intraventricular hemorrhage (IVH). Aquaporin 4 (AQP4) participates the balance of cerebrospinal fluid secretion and absorption. The current study investigated AQP4 formation caused by iron after IVH. Methods There were three parts to this study. First, Sprague–Dawley rats received injection 100 µl autologous blood or saline control. Second, had IVH treated with deferoxamine (DFX), chelator,...

10.1007/s12028-023-01746-w article EN cc-by Neurocritical Care 2023-05-19

Summary Introduction: Circulating endothelial cells (ECs) are known to reflect injury, and injury is associated with graft‐versus‐host disease (GVHD). We hypothesised that circulating ECs might be systemic acute (aGVHD). Methods: BALB/c (H‐2k d ) mice were treated total body irradiation then infused C57B/6‐derived T‐cell‐depleted bone marrow (TCD‐BM) or TCD‐BM splenocytes. Cyclosporine was used prevent aGVHD. allogeneic lymphocytes analysed by flow cytometry at multiple time points. The...

10.1111/j.1751-553x.2011.01322.x article EN International Journal of Laboratory Hematology 2011-05-24

The pathophysiological mechanisms of intermittent claudication (IC) progression to chronic limb-threatening ischemia (CLTI) are still vague and which patients with IC will become CLTI unknown. This study aimed investigate the key molecules pathways mediating by a quantitative bioinformatic analysis public RNA-sequencing database peripheral artery disease (PAD) screen biomarkers discriminating CLTI.The GSE120642 dataset was downloaded from Gene Expression Omnibus (GEO) database....

10.3389/fcvm.2022.864461 article EN cc-by Frontiers in Cardiovascular Medicine 2022-04-01

The discrepancy between the high technical success rate and relatively low clinical response of renal artery stenting (RAS) raises importance to identify atherosclerotic stenosis (ARAS) patients who are most likely benefit from RAS. This study aimed investigate feasibility accuracy blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) in predicting split function (SRF) improvement after RAS with ARAS.Thirty severe ARAS were treated enrolled. Baseline cortical medullary R2*...

10.3389/fcvm.2022.793777 article EN cc-by Frontiers in Cardiovascular Medicine 2022-02-28
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