A5101098697- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Dementia and Cognitive Impairment Research
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- EEG and Brain-Computer Interfaces
- Syphilis Diagnosis and Treatment
- Schizophrenia research and treatment
- Neurological Disease Mechanisms and Treatments
- Blood Pressure and Hypertension Studies
- Neuroscience and Music Perception
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Face Recognition and Perception
- Fluoride Effects and Removal
- Body Image and Dysmorphia Studies
- Bipolar Disorder and Treatment
- Medicinal Plants and Neuroprotection
- Islanding Detection in Power Systems
- Epilepsy research and treatment
- Esophageal and GI Pathology
- HIV, TB, and STIs Epidemiology
Guiyang Medical University
2025
Affiliated Hospital of Guizhou Medical University
2025
Guangzhou Medical University
2016-2025
Southern Medical University
2020-2025
Second Affiliated Hospital of Guangzhou Medical University
2025
Qingdao Eighth People's Hospital
2024
Guangzhou Psychiatric Hospital
2016-2023
Abstract INTRODUCTION With the advancement of disease‐modifying therapies for Alzheimer's disease (AD), validating plasma biomarkers against cerebrospinal fluid (CSF) and positron emission tomography (PET) standards is crucial in both research real‐world settings. METHODS We measured phosphorylated tau (p‐tau)217, p‐tau181, amyloid beta (Aβ)1‐40, Aβ1‐42, neurofilament light chain cohorts. Participants were categorized by brain status using US Food Drug Administration/European Medicines...
Odor identification dysfunction occurs early in Alzheimer's disease (AD) and is considered a preclinical symptom along with subjective cognitive decline (SCD). Nevertheless, whether subjects SCD are co-symptomatic odor remains unclear.To compare the degree of assess relation between performance AD spectrum (including SCD, mild impairment (MCI), AD).Patients (84 129 MCI, 52 AD) 35 controls underwent Sniffin' Sticks Screen 16 test comprehensive neuropsychological examination.Odor scores were...
Abstract Background Odor identification (OI) dysfunction is an early marker of Alzheimer’s disease (AD), but it remains unclear how olfactory-related regions change from stages subjective cognitive decline (SCD) and mild impairment (MCI) to AD dementia. Methods Two hundred sixty-nine individuals were recruited in the present study. The defined as interest, grey matter volume (GMV), low-frequency fluctuation, regional homogeneity (ReHo), functional connectivity (FC) compared for exploring...
Abnormal apoptosis both maintains endometrial cell growth and induces pathogenesis. The etiology of endometriosis is unclear no treatment curative. Therefore, the aim herein was to identify genes involved in pathogenesis endometriosis. Using data from our previous results RNA sequencing normal tissue ovarian endometrioma (OMA) tissue, along with Gene Expression Omnibus (GEO) dataset on endometriosis, we identified an apoptotic-related gene, meis homeobox I (MEIS1). Normal endometrium,...
<h3>Background</h3> Patients with late-life depression (LLD) suicidal ideation (SI) often have more explicit suicide plans, and attempts among older adults are highly lethal than in other age groups. Increasing evidence suggests that people SI exhibit abnormal brain network connectivity; however, the relationship between LLD dynamics is still unclear. <h3>Methods</h3> We recruited patients (LLD-SI), without (LLD-NSI), age-matched healthy adults. collected 64-channel resting state...
Late-life depression patients are at a high risk of developing Alzheimer's disease, and diminished olfactory identification is an indicator in early screening for disease the elderly. However, whether associated with late-life remains unclear.One hundred twenty-five patients, 50 60 normal controls were continuously recruited. The participants underwent clinical evaluation, test, neuropsychological assessment, neuroimaging assessment.The impairment was milder than that patients. Diminished...
Patients with late life depression (LLD) have a higher incident of developing dementia, especially individuals memory deficits. However, little is known about the white matter characteristics LLD deficits(LLD-MD) in human connectome, for rich-club coefficient, which an indicator that describes organization pattern hub network. To address this question, diffusion tensor imaging 69 participants(15 LLD-MD patients; 24 patients intact memory(LLD-IM); and 30 healthy controls(HC)) was applied to...
Neurosyphilis is caused by the invasion of Treponema pallidum into central nervous system. General paresis (GP) a type neurosyphilis. The main manifestation general dementia; however, this different from other types dementia, which can be cured adequate doses penicillin in early stage. "great imitator" because it mimic many medical disorders. In addition, manifestations neurosyphilis are not typical. Psychiatric disorders as cause have become more common due to use antibiotics. Patients with...
Abstract Background Acute myocardial infarction (AMI) is a serious cardiovascular disease that adversely affects human health. Circular RNAs (circRNAs) are involved in the pathological and physiological processes of AMI, but biological mechanism their involvement clinical significance remain unknown. We aimed to identify circRNAs significantly associated with morbidity peripheral blood patients AMI evaluate diagnostic utility. Methods High-throughput sequencing was used screen for...
Objectives: Although previous studies have extensively confirmed the cross-sectional relationship between cognitive impairment and depression in depressed elderly patients, findings of their longitudinal associations are still mixed. The purpose this study was to explore two-way causal symptoms cognition patients with late-life (LLD). Methods: A total 90 LLD were assessed across two time points (baseline 1-year follow up) on measures 3 aspects depressive symptoms. data then fitted a...
Abstract Aims The present study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) nonamnestic (naMCI), which enhances understanding their different pathophysiologies provides targets for individualized intervention. Methods Sixty‐five naMCI 48 aMCI subjects 75 healthy controls were recruited. A sliding window analysis was used evaluate dynamic amplitude low‐frequency (dALFF), regional homogeneity (dReHo), functional...
Cognitive impairment in late-life depression (LLD) is considered to be caused by neurodegenerative changes. Elevated homocysteine (Hcy) levels may linked cognitive abnormalities associated with LLD. The important role of white matter (WM) damage and pathogenesis patients LLD has been widely reported. However, no research explored the interrelationships these features LLD.The goal study was examine interrelationship between Hcy levels, cognition, variations WM microstructure detected...
Abstract Background Subjective cognitive decline (SCD) is a putative Alzheimer’s disease (AD) precursor without objective neuropsychological deficits. The hippocampus plays an important role in function and emotional responses generally aberrant SCD. However, previous studies have mainly focused on static functional connectivity (sFC) by resting-state magnetic resonance imaging (fMRI) SCD individuals, it remains unclear whether hippocampal dynamic (dFC) changes exist those are associated...
Microglia play a crucial role in regulating the progression of traumatic brain injury (TBI). In specific, microglia can self-activate and secrete various substances that exacerbate or alleviate neuroimmune response to TBI. addition, microRNAs (miRNAs) are involved functional regulation microglia. However, molecular markers reflect dynamics TBI have not yet been found peripheral tissues. Paired samples blood were collected from patients with before after treatment. Next-generation sequencing...
Negative bias in cognition is closely associated with susceptibility to recurrent episodes of depression. Given the high recurrence rate depression, previous studies have focused on attentive level late-life depression (LLD), but relapse difficult detect as a lower chief complaint elderly people. Facial expression mismatch negativity (EMMN) tool that can measure cognitive pre-attentive processing. In this study, we sought explore emotional information processing LLD. Thirty patients remitted...
Olfactory identification (OI) deficits have been regarded as an indicator of cognitive impairment in the elderly, but few studies analyzed mixed effect depression on OI. Since is common elderly and strongly associated with OI, we aimed to explore whether comorbidit y may be worse outcomes. In total, 153 patients 154 normal were recruited. Subjects underwent assessments depression, function, Information factors that affect OI performance was collected (age, sex, smoking history, diabetes,...
Abstract Early detection of patients with late-life depression (LLD) a high risk developing dementia contributes to early intervention. Odor identification (OI) dysfunction serves as marker for predicting dementia, but whether OI increases the in LLD remains unclear. The present study aimed explore interactive effect and on its underlying neuroimaging changes. One hundred fifty-seven 101 normal controls were recruited, data their OI, cognition, activity daily living (ADL), resting-state...
Abstract Background Slowed information processing speed (IPS) is the core contributor to cognitive impairment in patients with late-life depression (LLD). The hippocampus an important link between and dementia, it may be involved IPS slowing LLD. However, relationship a slowed dynamic activity connectivity of hippocampal subregions LLD remains unclear. Methods One hundred thirty-four 89 healthy controls were recruited. Sliding-window analysis was used assess whole-brain functional (dFC),...
Patients with schizophrenia consistently exhibit abnormalities in the N170 event-related potential (ERP) component evoked by images of faces. However, relationship between these face-specific patients and clinical characteristics this disorder has not been elucidated. Here, ERP recordings were conducted for healthy controls. The amplitude latency recorded while participants passively viewed face non-face (table) to explore correlation processing schizophrenia. results provided evidence a...
Our previous study in animal models revealed that bilirubin could induce Aβ formation and deposition. Bilirubin may be important neurodegenerative dementia with Hence, lowering the concentration of free capable crossing blood brain-barrier benefit treatment Alzheimer's disease (AD).The objectives this were to examine change serum albumin concentrations patients deposition, determine effects intravenous administration AD.Bilirubin deposition examined. Cell viability apoptosis determined...
Background: Odor identification dysfunction is an early predictor of the development Alzheimer's disease (AD), but neuropsychiatric symptoms (NPS), which are common in AD and mild cognitive impairment (MCI), also associated with odor dysfunction. Whether NPS affect specificity using to predict decline MCI remains unclear. Methods: Patients (233 45 AD) healthy controls (HCs) underwent assessments (Sniffin' Sticks), (Neuropsychiatric Inventory-12), function (global cognition, memory, language,...
Functional abnormalities of the habenula in patients with depression have been demonstrated an increasing number studies, and is involved cognitive processing. However, whether late-life (LLD) exhibit disrupted habenular functional connectivity (FC) FC mediates relationship between depressive symptoms impairment remain unclear.