A5101734329- Reproductive Biology and Fertility
- Ovarian function and disorders
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Facial Trauma and Fracture Management
- Facial Rejuvenation and Surgery Techniques
- Saffron Plant Research Studies
- Radiation Dose and Imaging
- Facial Nerve Paralysis Treatment and Research
- Mesenchymal stem cell research
- Regional Development and Environment
- Genetics, Aging, and Longevity in Model Organisms
- Phytoestrogen effects and research
- Flavonoids in Medical Research
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Educational Reforms and Innovations
- Prenatal Screening and Diagnostics
- Tea Polyphenols and Effects
- MRI in cancer diagnosis
- Kruppel-like factors research
- Hops Chemistry and Applications
- Bioactive natural compounds
- Hepatocellular Carcinoma Treatment and Prognosis
First Affiliated Hospital of Zhengzhou University
2021-2023
Zhengzhou University
2022
Harbin Medical University
2015
Fourth Affiliated Hospital of Harbin Medical University
2015
Background Intracytoplasmic sperm injection (ICSI) has tremendous advantages for resolving the problem of male infertility. However, ICSI fertilization can fail in some patients because various reasons, primarily failure oocyte activation. Oocytes have been activated using calcium ionophore (A23187) previous clinical cases failure. studies on efficiency activation, its effects developmental potential embryos, and pregnancy outcomes after embryo transfer are relatively limited. Methods In...
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is an extracellular matrix that plays important role in the process of ovulation. According to previous studies, expression level ADAMTS1 granulosa cells polycystic ovarian syndrome (PCOS) patients mechanism for regulating oocyte quality embryonic development potential are still unclear. Our research clarified was significantly increased PCOS as compared ovulatory controls. After silencing cells, cell proliferation E...
The mammalian follicle is the basic functional unit of ovary, and its normal development required to obtaining oocytes capable fertilization. As women get older or decline in ovarian function due certain pathological factors, growth follicles becomes abnormal, which ultimately leads infertility other related female diseases. Kuntai capsules are currently used clinical practice improve function, they contain natural compound Baicalin, a with important biological activities. At present, role...
Ovarian aging refers to the gradual decline of ovarian function with increasing physiological age, manifested as decreased reserve, elevated aging-related markers, and reduced oocyte quality. With a declining female fertility growing population, it is urgent delay maintain improve life quality women. Theaflavin 3, 3'-digallate (TF3) naturally bioactive polyphenol compound extracted from black tea, its antioxidant properties play an important role in maintaining human health delaying aging;...
Abstract Background Follicular development in mammalian ovaries is a complex and dynamic process, the interactions regulatory-feedback loop between follicular microenvironment, granulosa cells (GCs), oocytes can affect normal ovary functions. Abnormalities any part of process may cause abnormal development, resulting infertility. Hence, exploring pathogenesis extremely important for diagnosing treating infertile women. Methods RNA sequencing was performed with ovarian cortical tissues...
Abstract From the collection of human follicular fluid to isolation primary granulosa cells, duration these two time points is variable. And there no specific experiment explore which temperature will make cell state better in subsequent experiments. In this study, collected was divided into 7 groups: one fresh control group, three vitro storage temperatures (4℃, Room Temperature, and 37℃) times (4h 8h). After isolating they were cultured evaluate their function. The results showed that...
Abstract At present, embryo morphology assessment based on the observation of embryonic morphological characteristics at several specific time points has been mainly used for selecting high-quality embryo. However, we all know that development is a dynamic process. Many research results correlation between morphokinetic parameters and quality potential were inconsistent. With help time-lapse imaging, processes outcomes total 365 embryos cultured analyzed in this study. The showed mean tPNf...