A5030045781- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Advanced Radiotherapy Techniques
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer therapeutics and mechanisms
- Neuroblastoma Research and Treatments
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- ZnO doping and properties
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Tracheal and airway disorders
- GaN-based semiconductor devices and materials
- Viral-associated cancers and disorders
Sun Yat-sen University Cancer Center
2022-2024
Sun Yat-sen University
2022-2024
Zhejiang Cancer Hospital
2016-2024
Chinese Academy of Sciences
2019-2024
University of Chinese Academy of Sciences
2020-2023
State Key Laboratory of Oncology in South China
2023
Cancer Hospital of Chinese Academy of Medical Sciences
2021
Soochow University
2019-2020
Wenzhou Medical University
2017-2018
Zhejiang Hospital
2017
Abstract Purpose: In this multicenter phase 3 trial, the efficacy and safety of 60 Gy 50 doses delivered with modern radiotherapy technology for definitive concurrent chemoradiotherapy (CCRT) in patients inoperable esophageal squamous cell carcinoma (ESCC) were evaluated. Patients Methods: pathologically confirmed stage IIA‒IVA ESCC randomized 1:1 to receive conventional fractionated or tumor regional lymph nodes. Concurrent weekly chemotherapy (docetaxel 25 mg/m2; cisplatin mg/m2) two...
Background The thoracic radiotherapy (TRT) target volume for limited‐stage small‐cell lung cancer (SCLC) has been controversial decades. In this report, the final results of a prospective randomized trial on TRT before and after induction chemotherapy are presented. Methods After 2 cycles etoposide cisplatin, patients arm were to receive postchemotherapy or prechemotherapy tumor in study control arm. Involved‐field was received both arms. consisted 1.5 grays (Gy) twice daily 30 fractions up...
The optimal treatment for elderly patients with early-stage non-small cell lung cancer (NSCLC) remains inconclusive. Previous studies have shown that stereotactic body radiotherapy (SBRT) provides encouraging local control though higher incidence of toxicity in than younger populations. objective this study was to compare the outcomes SBRT and surgical clinical stage I-II NSCLC.This retrospective analysis included 205 aged ≥70 years I NSCLC who underwent or surgery at Zhejiang Cancer...
Gray matter (GM) damage after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients can result cognitive impairment, while there may be no visible brain tissue change according to the conventional magnetic resonance imaging (MRI). This study investigated radiation-induced GM volume differences between NPC who received RT and those did not.High-resolution structural MRI data from two groups of were acquired. The pre-RT group was composed 56 newly diagnosed but not yet medically treated...
Purpose To accurately assess disease progression after Stereotactic Ablative Radiotherapy (SABR) of early-stage Non-Small Cell Lung Cancer (NSCLC), a combined predictive model based on pre-treatment CT radiomics features and clinical factors was established. Methods This study retrospectively analyzed the data 96 patients with NSCLC treated SABR. Clinical included general information (e.g. gender, age, KPS, Charlson score, lung function, smoking status), lesion status diameter, location,...
Objectives: To explore the relationship between peripheral blood inflammation parameters and overall survival (OS) progression-free (PFS) of early-stage non-small cell lung cancer patients who underwent stereotactic body radiotherapy (SBRT). Patients methods: In this study, eligible treated with SBRT from 2013 to 2018, both serum complete count biochemical results were available prior (within 60 days) included. Results: A review hospital registries identified 148 patients, 5-year OS PFS...
Patients who previously underwent surgical resection of initial primary lung cancer are at a high risk developing multiple cancers (MPLCs). The purpose this study was to compare the efficacy and safety between stereotactic body radiation therapy (SBRT) surgery for MPLCs patients after prior radical first cancers.In multicenter retrospective study, eligible MPLC with tumor diameter 5.0 cm or less N0M0 SBRT reoperation January 2013 August 2020 were enrolled. endpoint 3-year locoregional...
An accurate, reproducible, and comfortable immobilization device is essential for stereotactic radiotherapy (SBRT) in patients with lung cancer. This study compared thermoplastic masks (TMP) vacuum cushion (VCS) system to assess the differences interfraction intrafraction setup accuracy impact of body mass index (BMI) respect choice. retrospective was conducted on treated SBRT between 2012 2015 at Zhejiang cancer hospital. The treatment analyzed 121 patients. A total 687 cone beam computed...
Background: The objective of this study was to evaluate the clinical efficacy stereotactic body radiotherapy (SBRT) and surgical treatment for stage I–II non-small cell lung cancer (NSCLC). Methods: This retrospective analysis included 879 patients with primary NSCLC who underwent SBRT or in Zhejiang Cancer Hospital, Hangzhou, China from January 2012 December 2017. Results: Propensity score matching (PSM) performed between two groups. Each group 66 met inclusion criteria. median follow-up...
Definitive treatment of lung cancer with radiotherapy is challenging, as respiratory motion and anatomical changes can increase the risk severe off-target effects during radiotherapy. Online adaptive (ART) an evolving approach that enables timely modification a plan interfraction radiotherapy, in response to physiologic or anatomic variations, aiming improve dose distribution for precise targeting delivery patients. The effectiveness online ART depends on seamless integration multiple...
Surgery and stereotactic body radiotherapy (SBRT) are both suitable treatment options for early stage Non-small cell lung cancer (NSCLC), which accounts the majority of cancer. This study compared outcomes sublobar resection (SLR) SBRT in patients with T1-2N0M0 NSCLC tumor size ≤5 cm.Patients who underwent SLR or between January, 2012 December, 2016 were included this retrospective study. The survival toxicity cohorts using Kaplan-Meier plots. In a second exploratory analysis, propensity...
A prospective phase II study showed that Endostar combined with concurrent chemoradiotherapy (CCRT) can improve overall survival (OS) in patients inoperable locally advanced non-small cell lung cancer (NSCLC). This aimed to retrospectively compare the 5-year rates of NSCLC who received a combination and CCRT receiving CCRT.Treatment-naive had long-term follow-up data were included this study. Patients + group treated plus radical CCRT, CCRT. For radiation dose ≥60 Gy, Kaplan-Meier method was...
Compared the overall outcomes of video-assisted thoracoscopic surgery (VATS) versus stereotactic body radiotherapy (SBRT) for stage I-II non-small cell lung cancer (NSCLC).We retrospectively compared survival (OS), cancer-specific (CSS), locoregional control (LRC), and disease-free (DFS) at our institution between January 2012 December 2016. Propensity score-matching was performed to reduce patient selection bias based on age, gender, Karnofsky performance score, Charlson comorbidity index,...
Computed tomography (CT) appearance pattern after lung tumor stereotactic body radiation therapy(SBRT) might predicts survival. This study aimed to investigate the correlation between CT SBRT and outcomes in patients with early-stage non-small-cell cancer (NSCLC).Clinical data of inoperable NSCLC undergoing were retrospectively analyzed from 2012 2015 at Zhejiang Cancer Hospital. The relationship patient's survival was analyzed.The 173 treated analyzed. One month SBRT, diffuse consolidation...
Oligometastatic non-small-cell lung cancer (NSCLC) is potentially curable. Oligo-recurrence occurs with oligometastatic disease characterized by well-controlled primary lesion. The purpose of the present study was to explore value definitive local therapy (DLT) for extracranial single-organ oligorecurrent NSCLC. A total 81 patients NSCLC who had oligorecurrence after receiving radical treatment at Cancer Hospital University Chinese Academy Sciences from January 2010 December 2017 were...
e20057 Background: Immune checkpoint inhibitors (ICIs) have become the standard consolidation therapy for stage III unresectable non-small cell lung cancer (NSCLC). Whether induction ICIs combined with chemotherapy can further improve efficacy is controversial. In this study, we used real-world data to explore possibility of plus before definitive chemoradiation (CRT). Methods: Patients NSCLC (including postoperative recurrence), who received CRT from 2016 2022, was retrospective reviewed....
e20038 Background: The frequent false-positive results of lung cancer screening low-dose computed tomography (LDCT) remains a challenge. In this study, we aimed to establish novel panel cancer-specific methylated regions detected from circulating cell-free DNA (cfDNA) for differentiating malignant pulmonary nodules (PNs) benign lesions in high-risk patients. Methods: We performed methylation profiling by high throughput bisulfite sequencing tissue samples (nodule size < 3 cm diameter)...
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC). TQB2450 (benmelstobart) is a novel humanized immunoglobulin G1 monoclonal antibody against programmed death-ligand 1 (PD-L1). Anlotinib, an oral multitargeted anti-angiogenic agent with potential synergy ICIs, has shown efficacy in relapsed and advanced NSCLC. Accumulating preclinical data suggest synergism between immunological therapies through improvement immune microenvironment...
This study is to analyse the failure patterns and long-term survival after stereotactic body radiotherapy (SBRT) in patients with T1-3N0M0 inoperable non-small cell lung cancer (NSCLC). Early-stage NSCLC patitents who received SBRT at Zhejiang Cancer Hospital from January 2012 September 2018 were retrospectively analyzed. The primary endpoint of disease progression, which divided into local recurrence, regional failure, distant metastasis. Kaplan-Meier method analysis was used calculate...