A5051776059- Biosensors and Analytical Detection
- RNA modifications and cancer
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Photonic Crystals and Applications
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Ultrasound and Hyperthermia Applications
- Extracellular vesicles in disease
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- Cancer, Hypoxia, and Metabolism
- Photodynamic Therapy Research Studies
- Fatty Acid Research and Health
- Catalytic C–H Functionalization Methods
Zhongda Hospital Southeast University
2016-2024
Indiana University School of Medicine
2021
Southeast University
2015-2018
Zhejiang Normal University
2017
State Key Laboratory of Digital Medical Engineering
2016
One of the main problems in B cell lymphoma treatment is severe adverse effects and low therapeutic efficacy resulting from systemic chemotherapy. A pH-sensitive controlled drug release system based on mesoporous silica nanoparticles was constructed for targeted delivery to tumor cells reduce toxicity improve efficacy. In this study, doxorubicin (DOX) filled into mesopores functional MSNs (DMSNs). Furthermore, rituximab introduced as motif DMSNs using an avidin-biotin bridging method...
Background Lung metastasis is the primary cause of breast cancer-related mortality. Neutrophil extracellular traps (NETs) are involved in progression cancer. However, mechanism NET formation not fully understood. This study posits that tumor cell-released autophagosomes (TRAPs) play a crucial role this process. Methods TRAPs were isolated from cancer cell lines to analyze their impact on both human and mouse neutrophils. The used vitro vivo models, including Toll-like receptor 4 (TLR4 − / )...
Tumor metabolism plays a pivotal role in shaping immune responses within the tumor microenvironment influencing progression, evasion, and efficacy of cancer therapies. Radiotherapy has been shown to impact both modulation, often inducing activation through damage-associated molecular patterns STING pathway. In this study, we analyse particular characteristics tumour metabolic its effect on microenvironment. We also review changes that are induced by radiotherapy, with focus sensitisation...
Abstract An iodine‐mediated oxidative ring contraction of cyclobutanols has been developed. The reaction allows the synthesis a wide range aryl cyclopropyl ketones under mild and eco‐friendly conditions. A variety functional groups including aromatic or alkyl halides, ethers, esters, ketones, alkenes, even aldehydes are nicely tolerated in reaction. This is contrast with traditional synthetic approaches for which poor group tolerance often problem. practicality method also highlighted by...
Wound healing is a ubiquitous healthcare problem in clinical wound management. In this paper, the fabrication of graphene hybrid supramolecular hydrogel (GS hydrogel) for dressing applications demonstrated. The composed two components, including N-acryloyl glycinamide (NAGA) as scaffold and photothermally responsive active site photothermal therapy. Based on multiple hydrogen bonds between dual amide motifs side chain glycinamide, exhibits high tensile strength (≈1.7 MPa), good...
Acute myocardial infarction (AMI) is a leading cause of death and disability worldwide. Early diagnosis AMI interventional treatment can significantly reduce damage. However, owing to limitations in sensitivity specificity, existing markers are not efficient for early identification AMI. Transcriptome-wide association studies (TWASs) have shown excellent performance identifying significant gene-trait associations several cardiovascular diseases (CVDs). Furthermore, ferroptosis major driver...
Most breast cancer-related deaths are caused by metastasis in vital organs including the lungs. Development of supportive metastatic microenvironments, referred to as premetastatic niches (PMNs), certain distant before arrival cells, is critical metastasis. However, mechanisms PMN formation not fully clear. Here, we demonstrated that chemoattractant C-C motif chemokine ligand 2 (CCL2) could be stimulated heat shock protein 60 (HSP60) on surface murine 4 T1 cancer cell-released LC3+...
Chemokines have been reported to play an important role in cancer immunotherapy. This study aimed explore the chemokines involved lung immunotherapy.All public data were downloaded from The Cancer Genome Atlas Program database. Quantitative real time-PCR was used detect mRNA level of specific molecules and Western blot for protein level. Other experiments include luciferase reporter experiments, flow cytometric analysis, Chromatin immunoprecipitation assay, ELISA co-cultured system.We found...
Abstract Programmed death (PD) 1/PD ligand 1 (PDL1) inhibitors are immune checkpoint (ICIs) that may facilitate HER2‐positive breast cancer treatment; however, their clinical efficacy remains elusive. Oxygen‐enhanced photodynamic therapy (PDT) increases immunogenic cell (ICD), providing a promising strategy to render the tumor microenvironment more sensitive ICIs. Lipid‐encapsulated oxygen nanobubbles (Lipo‐NBs‐O 2 ) obtained using (NBs) water for delivery in vivo can enhanced PDT. Here,...
Pancreatic cancer is a common cause of worldwide cancer-related mortality with poor 5-year survival rate. Aldehyde dehydrogenase (ALDH) activity possible marker for malignant stem cells in solid organ systems, including the pancreas, and N,N-diethylaminobenzaldehyde (DEAB) able to inhibit ALDH activity. In present study, role DEAB treatment pancreatic potential underlying mechanisms were investigated. The activities cell lines treated or without analyzed by an ALDEFLUOR™ assay. Cell Counting...
BACKGROUND Immune-checkpoint inhibitors have propelled the field of therapeutics for small cell lung cancer (SCLC) treatment, but are only beneficial to some patients. The objective this study was identify valid biomarkers good potential response immunotherapy. MATERIAL AND METHODS We performed an integrated analysis available datasets from Gene Expression Omnibus (GEO) projects, Cancer Cell Line Encyclopedia (CCLE), TISIDB database, and Lung Explorer (LCE) database. Six prognosis-related...
Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer. Studies have found that miR-1293 related to survival LUAD patients. Unfortunately, its role in remains not fully clarified.miR-1293 expression and association with patients' clinical characteristics were analyzed TCGA database. Also, was detected cell lines. Cell viability, migration, invasion MMP2 MMP9 measured cells following transfection mimic or antagomir. Phosphoglucomutase (PGM) 5 identified be negatively...
Abstract We developed a low‐cost polymer‐film spiral inertial microfluidic device for the effective size‐dependent separation of malignant tumor cells. The was fabricated in polymer films by rapid laser cutting and chemical bonding. After fabricating prototype device, performance our evaluated using particles effects operational flow rate, cell diameter, concentration on were explored. Our successfully separated cells from polydisperse white blood according to their different migration modes...
Aim: Severe cardiac toxicity of doxorubicin and an immunosuppressive tumor micro-environment become main obstacles for the effective treatment B-cell lymphoma. In this research, rituximab-conjugated doxorubicin-loaded microbubbles (RDMs) were designed exploring a combination approach targeted with ultrasound (US) irradiation PD-1 inhibitor to overcome mentioned above. Methods: vivo studies performed on SU-DHL-4 cell-grafted mice ex CD20+ human cells T cells. Results: A greater therapeutic...
The silica–agarose photonic beads array brings a novel approach to the combined detection of tumor markers in early cancer screening because it has high accuracy, reproducibility, and acceptable agreement with common clinical method.
For multiplex bioassays, one effective strategy is to employ microfluidic chips based on an array of photonic crystal beads (PCBs) that are encoded by their characteristic reflection spectrum (CRS). In this paper, we report a hyperspectral imaging system and algorithms for the high throughput decoding PCB subsequent detection. The results showed accuracy up ∼500 PCBs 98.56% with excellent ability extract low-intensity fluorescence intensities. also demonstrated techniques which can...