A5054632227- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- BRCA gene mutations in cancer
- RNA Research and Splicing
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Oral Health Pathology and Treatment
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Mycobacterium research and diagnosis
- Immune cells in cancer
- Nutrition, Genetics, and Disease
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Pharmacological Effects of Natural Compounds
- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Head and Neck Cancer Studies
- Growth Hormone and Insulin-like Growth Factors
- Nuclear Receptors and Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Protein Degradation and Inhibitors
Second Xiangya Hospital of Central South University
2018-2025
Central South University
2018-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Zhejiang University
2018-2024
Hunan University of Traditional Chinese Medicine
2024
Guangxi Medical University
2017-2024
First Affiliated Hospital Zhejiang University
2020-2024
Changsha Hospital for Maternal and Child Health Care
2024
Community Health Center
2024
Zhejiang Gongshang University
2022
The abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs and long ncRNAs, often contribute to the development cancers. miR-200c functions a tumour suppressor that impacts growth bladder cancer cells epithelial-to-mesenchymal transition (EMT). LncRNA X inactive specific transcript (XIST) is highly expressed in tissues, promotes progression might act an miRNA molecular sponge. This study aimed examine relationship between lncRNA XIST assess their regulation stemness properties...
Abstract Background While observational studies and experimental data suggest a link between oral lichen planus (OLP) cavity cancer (OCC), the causal relationship role of inflammatory cytokines remain unclear. Methods This study employed univariable multivariable Mendelian Randomization (MR) analysis to investigate OLP risk OCC. Additionally, potential in modulating this association was explored. Instrumental variables were derived from genetic variants associated with ( n = 377,277)...
AbstractThe aim of this study was to determine whether polysaccharopeptide (PSP) and Astragalus polysaccharides (APS) can be combined together as a new complex prescription (PSP + APS) for aiding adriamycin (AMD) chemotherapy. Ehrlich's ascites carcinoma (EAC) used establish solid tumor model in Kunming mice. Immunocytochemical immunohistochemical analysis were employed detect the immunoregulatory anti-tumor effects EAC bearing mice after 30 days administration with PSP APS. APS could...
Purpose: As a malignancy that develops from breast tissue, cancer has been widely regarded as the most common type of threatening health women worldwide. Emerging evidence demonstrated tsRNAs might play vital part in tumorigenesis and progression several types cancers. However, functions remain largely unknown. Here, we investigated tsRNA-26576 cancer. Patients methods: In this study, tsRNA deregulation states patients (four tissues four adjacent normal tissues) were evaluated using small...
To gain more information on the prevalence of germline mutations in BRCA1/2 and PALB2 genes Chinese population, to explore effects mutation status these clinical outcomes patients with breast cancer, we performed a screening for consecutive series unselected cancer population. A total 2,769 cases were enrolled between June 1993 September 2017. All exons exon–intron boundaries screened next‐generation sequencing. Of patients, BRCA1 , BRCA2 accounted 2.7% (n = 74), 76), 0.9% 24), respectively....
This study aims to comprehensively analyze the diagnosis and prognosis of lncRNAs in hepatocellular carcinoma (HCC). From Gene Expression Omnibus database, we screened out analyzed differently expressed related mRNAs using bioinformatics methods. The expressions were validated tumor tissues, cell lines Cancer Genome Atlas database. At same time, also conducted an exploratory analysis on diagnostic prognostic ability HCC. In this study, found that most targeted promote biological process...
MIBC (muscle invasive bladder cancer) only accounts for a minority of cancers, however, the disease-specific and overall survival rates patients with are low. Macrophage M2 polarization has been reported to be associated poorer prognosis in cancer. Through cancer bioinformatics experimental analyses, FGF9 was found upregulated tissues. knockdown T24 cells strongly suppressed viability, migratory capacity, capacity cells; culture medium from (si-FGF9-CM) significantly inhibited macrophage...
// Huaping Chen 1, * , Siyuan Shan Li Zhijian 1 Xuan Zhu Meiyu Dai Lingxi Kong Xiaodan Lv Zhili Huang and Xue Qin Department of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning 530021, Guangxi, China These authors contributed equally to this work should be considered as co-first Correspondence to: Qin, email: qinxue919@126.com Keywords: des-gamma-carboxyprothrombin, AFP, hepatocellular cancer, diagnosis, meta-analysis Received: June 22, 2017 Accepted: July...
<h3>Objective:</h3> Circulating tumor cells (CTCs) play a critical role in cancer metastasis, but their prevalence and significance remain unclear. This study attempted to track the epithelial-mesenchymal transition (EMT) status of CTCs breast patients investigate clinical relevance. <h3>Methods:</h3> In this study, established negFACS-IF:E/M platform was applied isolate rare characterize EMT cancer. A total 89 were recruited, including stage 0–III (<i>n</i> = 60) late 29) cases....
ABSTRACT Bladder cancer (BCa) is an aggressive malignancy of urinary system. Aerobic glycolysis refers to the phenomenon wherein cells increase glucose consumption and produce lactic acid. Our study focused on role mechanism circST6GALNAC6 in BCa glycolysis. The 24 h intake was detected using flow cytometry. Lactic acid ATP were utilizing commercially provided kits. Extracellular acidification rate measured Seahorse XF‐96p Flux Analyzer. Cell proliferation determined colony formation assay....
UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family that regulates cell survival and apoptosis in ligand-dependent manner. UNC5B plays an important role development multiple cancers, including colorectal, bladder, thyroid cancer. However, exact expression pattern mechanism breast cancer have not been well elucidated. Here, we showed was significantly upregulated using bioinformatics analysis experimental validation. High correlated with poor overall patients. knockdown...
Five RecQ helicase family members have a role in maintaining genome stability. However, their prognostic roles breast cancer remain unknown. We aimed to investigate the values of and clinical outcomes cancer.We used Kaplan-Meier Plotter database (http://kmplot.com/analysis) analyze RecQ-family mRNA expression all cancers different intrinsic subtypes clinicopathological characteristics. Protein-expression levels WRN RECQL4 were confirmed by immunohistochemistry (IHC) tissues.Increased RECQL...
Bladder cancer is one of the most frequent urologic tumours in world. MicroRNA-200c (miR-200c) has been considered a regulator tumour angiogenesis. Akt2/mTOR was vascular endothelial growth factor (VEGF) and hypoxia-inducible 1α (HIF-1α). However, mechanism by which miR-200c regulates bladder angiogenesis remains unknown.Western blotting qRT-PCR were used to detect expression protein mRNA, respectively. Cell proliferation, migration invasion detected using MTT, wound-healing transwell...
Definitive treatment of lung cancer with radiotherapy is challenging, as respiratory motion and anatomical changes can increase the risk severe off-target effects during radiotherapy. Online adaptive (ART) an evolving approach that enables timely modification a plan interfraction radiotherapy, in response to physiologic or anatomic variations, aiming improve dose distribution for precise targeting delivery patients. The effectiveness online ART depends on seamless integration multiple...
Background: Fine particulate matter (particulate 2.5, PM2.5) is considered one of the harmful factors to neuronal functions. Apoptosis mechanisms injury induced by PM2.5. Methylcobalamine (MeCbl) has been shown have anti-apoptotic and neuroprotective effects. Objective: The current work tried explore effects that MeCbl protects mice against cognitive impairment apoptosis chronic real-time PM2.5 exposure. Methods: Twenty-four 6-week-old male C57BL/6 were exposed ambient fed with for 6 months....