A5103274514- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Circular RNAs in diseases
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Diabetes Treatment and Management
- Inflammation biomarkers and pathways
- Nematode management and characterization studies
- Diet, Metabolism, and Disease
- Macrophage Migration Inhibitory Factor
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Soybean genetics and cultivation
- Immune Response and Inflammation
- Diabetes Management and Research
- Mechanisms of cancer metastasis
- Legume Nitrogen Fixing Symbiosis
- Atrial Fibrillation Management and Outcomes
- Gastroesophageal reflux and treatments
- Gout, Hyperuricemia, Uric Acid
- GDF15 and Related Biomarkers
- Melanoma and MAPK Pathways
- RNA Research and Splicing
- Intensive Care Unit Cognitive Disorders
Sichuan University
2025
Huazhong University of Science and Technology
2013-2024
Tongji Hospital
2023-2024
Army Medical University
2018-2024
Fudan University
2024
Kunming University of Science and Technology
2024
Ministry of Ecology and Environment
2022
Zunyi Medical University
2022
Southwest Medical University
2021
Affiliated Hospital of Southwest Medical University
2021
Short, but significant, microRNAs (miRNAs) are an important class of gene regulators. Small-molecule modifiers miRNA function, such as 1 (see schematic representation), were identified in a cellular screen for miRNA-pathway inhibitors. Such compounds expected to be useful tools the elucidation detailed mechanisms action and may serve lead structures development new therapeutic agents. Detailed facts importance specialist readers published "Supporting Information". documents peer-reviewed,...
Background . Adipokines are reported to participate in many common pathologic processes of glucose dysregulation, such as insulin resistance, β -cell dysfunction, and chronic inflammation. Objective To detect the concentrations plasma asprosin subjects with impaired regulation (IGR) newly diagnosed type 2 diabetes (nT2DM) its relationship parameters lipid metabolism, pancreatic function. Methods 143 eligible participants were included divided into three groups including normal (NGR,...
Mitochondrial glycerol 3-phosphate dehydrogenase (mGPDH) is an integral component of the respiratory chain, and recent studies have suggested that it plays important role in hepatic glucose homeostasis. However, its function lipid metabolism unclear. Here, we identified a for mGPDH nonalcoholic fatty liver disease (NAFLD). Specifically, expression activity were lower livers from patients mice with NAFLD (ob/ob, high-fat diet [HFD] db/db). Liver-specific depletion or knockdown cultured...
Abstract Podocytes are particularly sensitive to lipid accumulation, which has recently emerged as a crucial pathological process in the progression of proteinuric kidney diseases like diabetic disease and focal segmental glomerulosclerosis. However, underlying mechanism remains unclear. Here, podocytes predominantly expressed protein dedicator cytokinesis 5 (Dock5) is screened be critically related podocyte lipotoxicity. Its expression reduced both patients mouse models. Podocyte‐specific...
Soybean is one of the most important food and oil crops in world. Plant height (PH) number nodes on main stem (NNMS) are quantitative traits closely related to soybean yield. In this study, we used 208 chromosome segment substitution lines (CSSL) populations constructed using "SN14" "ZYD00006" for trait locus (QTL) mapping PH NNMS. Combined with bulked segregant analysis (BSA) by extreme materials, 8 consistent QTLs were identified. According gene annotation QTL interval, a total 335 genes...
Research Article2 November 2018Open Access Source DataTransparent process Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration Xiufei Liu Translational Key Laboratory for Diabetes, Department of Endocrinology, Xinqiao Hospital, Third Military Medical University, Chongqing, China Search more papers by this author Hua Qu Yi Zheng Qian Liao Linlin Zhang Xiaoyu Xin Xiong Yuren Wang Rui Hui Qiang Tong Zhenqi Division Endocrinology and Metabolism, Internal...
Abstract Non‐healing diabetic wounds and ulcer complications, with persistent cell dysfunction obstructed cellular processes, are leading causes of disability death in patients diabetes. Currently, there is a lack guideline‐recommended hypoglycemic drugs clinical practice, likely due to limited research unclear mechanisms. In this study, it demonstrated that liraglutide significantly accelerates wound closure mouse models (db/db mice streptozotocin‐induced mice) by improving...
Abstract The abnormal mechanical stress has been considered as a major contributor of temporomandibular joint osteoarthritis (TMJOA), but the mechanism by which it leads to degeneration condylar cartilage remains elusive. double-stranded (dsDNA)-sensing cGAS/STING pathway serves response in many sterile inflammatory responses. In present study, we found that exerted on condyle chondrocytes induced dsDNA leakage from mitochondria cytoplasm activate STING. Upon activation, STING exacerbated...
Aim: The aim of this study was to explore whether the circulating frequency and function myeloid-derived suppressor cells (MDSCs) are altered in patients with acute coronary syndrome (ACS). Methods: MDSCs peripheral blood determined by flow cytometry, mRNA expression purified analyzed real-time reverse transcription polymerase chain reaction (RT-PCR). suppressive isolated from different groups also determined. plasma levels certain cytokines were using Bio-Plex Pro™ Human Cytokine Assays....
Cutaneous wound healing is a fundamental biologic and coordinated process, failure to maintain this process contributes the dysfunction of tissue homeostasis, increasing global burden diabetic foot ulcerations. However, factors that mediate are not fully understood. Here, we identify pivotal role dedicator cytokinesis 5 (Dock5) in keratinocyte functions contributing skin healing. Specifically, Dock5 highly upregulated during proliferative phase repair predominantly expressed epidermal...
Kurz, aber wichtig: microRNAs (miRNAs) spielen bei der Genregulierung eine bedeutende Rolle. Moleküle wie 1, die miRNA-Funktion verändern (siehe Schema), wurden in einem Zellscreening nach Inhibitoren des miRNA-Wegs identifiziert. Solche Verbindungen sollten Aufklärung detaillierter Mechanismen miRNA-Wirkung hilfreich sein und könnten als Leitstrukturen für Entwicklung neuer Therapeutika dienen.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is currently posing significant threats to public health worldwide. It notable that a substantial proportion of patients with sever COVID-19 have coexisting diabetic conditions, indicating the progression and outcome may relate diabetes. However, it still unclear whether treatment principles can be used for COVID-19.We conducted computational approach screen all commonly clinical oral...
Autoimmune myocarditis is caused by both innate and adaptive immune responses. Many studies have found that myeloid-derived suppressor cells (MDSCs) suppress T-cell responses reduce tolerance, while MDSCs may serve as a key player in inflammatory pathogenesis variety of autoimmune diseases. However, research into the role experimental (EAM) remains lacking.
Abstract The activity of proteinase is reported to correlate with the development and progression nonalcoholic fatty liver disease (NAFLD). Puromycin-sensitive aminopeptidase (PSA/NPEPPS) an integral nontransmembrane enzyme that functions catalyze cleavage amino acids near N-terminus polypeptides. A previous study suggested this acts as a regulator neuropeptide activity; however, metabolic function in has not been explored. Here, we identified novel role PSA hepatic lipid metabolism....
Objectives Patients with type 1 diabetes (T1D) face unique challenges in glycaemic control due to the complexity and uniqueness of dietary structure China, especially terms postprandial response (PPGR). This study aimed establish a personalized model for predicting PPGR patients T1D. Materials methods Data provided by First People’s Hospital Yunnan Province, 13 T1D, were recruited an intervention at least two weeks. All asked wear continuous glucose monitoring (CGM) device under free-living...
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer, the most common type of is facing challenges such as endocrine therapy resistance and distant relapse. Immunotherapy has shown progress in treating triple-negative but immunological research on HR+/HER2- cancer still its early stages. Here, we performed a multi-omics analysis large cohort patients (n = 351) revealed that possessed highly heterogeneous tumor immune microenvironment....
Background/Aims: Myeloid-derived suppressor cells (MDSCs) are increased in inflammatory and autoimmune disorders. This study aims to evaluate the significance of MDSCs dilated cardiomyopathy (DCM) patients. Methods: In total, 42 newly hospitalized DCM patients 39 healthy controls were enrolled study. The frequencies circulating CD14+HLA-DR-/low determined by flow cytometry. Then, functional properties suppressing T cell proliferation interferon-gamma (IFN-γ) production measured a co-culture...
Abstract Seed size is an important factor affecting soybean ( Glycine max ) yield and quality, the length width of pods are significantly related to seed size. Soybean two‐seed pod a stable pod‐setting trait. Based on chromosome segment substitution line (CSSL), QTL‐seq method was used locate QTL (TSPL) (TSPW) mine genes A total 3 QTLs for TSPL 5 TSPW were obtained. Among them, positions qTSPL‐B1‐1 qTSPW‐B1‐1 overlapped, this overlapping interval as major TSPW. Haplotype analysis revealed...