A5110646321- Gut microbiota and health
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Advancements in Transdermal Drug Delivery
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Gastrointestinal motility and disorders
- Fibroblast Growth Factor Research
- Probiotics and Fermented Foods
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Dermatology and Skin Diseases
- Inflammatory Bowel Disease
- Alzheimer's disease research and treatments
- Wound Healing and Treatments
- Psoriasis: Treatment and Pathogenesis
- Pancreatic function and diabetes
- Renal and related cancers
- Prenatal Screening and Diagnostics
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Retinoids in leukemia and cellular processes
- Ovarian function and disorders
First Affiliated Hospital of Zhengzhou University
2021-2025
Zhejiang University
2021-2025
Second Xiangya Hospital of Central South University
2020-2025
Central South University
2020-2025
First Affiliated Hospital of Xiamen University
2025
Second Affiliated Hospital of Zhejiang University
2024
Nanjing University of Chinese Medicine
2020-2024
City University of Hong Kong
2024
City University of Hong Kong, Shenzhen Research Institute
2024
Lanzhou University
2024
Abstract Over the past 70 years, semiconductor industry has undergone transformative changes, largely driven by miniaturization of devices and integration innovative structures materials. Two-dimensional (2D) materials like transition metal dichalcogenides (TMDs) graphene are pivotal in overcoming limitations silicon-based technologies, offering approaches transistor design functionality, enabling atomic-thin channel transistors monolithic 3D integration. We review important progress...
Nanomedicine-based photodynamic therapy (PDT) for melanoma treatment has attracted great attention. However, the complex design of polymer nanoparticles and high doses photosensitizers used in intravenous injections (for sufficient accumulation drugs tumor lesions) pose a huge challenge to commercialization further clinical application. Herein, we fabricated carrier-free nanoassemblies chlorin e6 (L-Ce6 NAs)-integrated fast-dissolving microneedles patch MNs) enriching only about 3 μg Ce6...
Patients with diabetes are at increased risk of HBV infection; however, the effects infection and anti-HBV therapy on management type 1 (T1D), 2 (T2D), latent autoimmune in adults (LADA) remain unclear. From 2016 to 2023, we recruited a multicenter cohort 355 HBV-infected inpatients, including 136 T1D, 140 T2D, 79 LADA. The control group included 525 HBV-uninfected comparing 171 204 T2D 150 We employed propensity-score matching between cases controls minimize confounding effects. Hemoglobin...
Patients with type 1 diabetes (T1D) and 2 (T2D) present intestinal disturbances. Recent epidemiological data have showed that, worldwide, over half of newly diagnosed T1D patients were adults. However, the gut microbial alterations in adult-onset are unclear. We aimed to identify signatures microbiota metabolites systematically, comparing T2D healthy controls (HCs).
Antihypertensive drugs were recently reported to have an oncogenic role in common cancer, however, whether these would affect the risk of hepatocellular carcinoma (HCC) remains unclear.A drug-target Mendelian randomization method was adopted examine long-term effect 12 antihypertensive classes on HCC Europeans and East Asians. To proxy drugs, we leveraged genetic variants located near or within drug target genes that associated with systolic blood pressure (SBP). Genetically proxied reduced...
Patients with Diabetic ketoacidosis (DKA) have increased critical illness and mortality during coronavirus diseases 2019 (COVID-19). The aim of our study was to develop a predictive model for the occurrence in COVID-19 patients DKA utilizing machine learning. Blood samples clinical data from 242 collected December 2022 January 2023 at Second Xiangya Hospital. were categorized into non-death (n = 202) death 38) groups, non-severe 146) severe 96) groups. We developed five learning-based...
Abstract In the physiological state, female fertility declines with age, as evidenced by a steady decline in oocyte quantity and quality. Aging of first organ, ovary, is accompanied increased oxidative stress levels causing ovarian reserve follicular atresia. Ferroptosis novel mode programmed cell death discovered recent years involved onset development various diseases. To investigate whether ferroptosis regulates aging, we examined granulosa cells from patients normal reserve, decreased...
Introduction Genome-wide association study identified C1QTNF6 as a candidate gene for type 1 diabetes (T1D) in Caucasians. We aimed to investigate if rs229541 conferred susceptibility T1D Chinese, independent of DR-DQ genotypes and this polymorphism affected the clinical profiles T1D. Methods In case–control study, were obtained from 1278 patients with 1282 nondiabetic controls using MassARRAY. Results Genotypic (P = 0.0210) allelic 0.0084) frequencies significantly different between group...
Abstract Aluminum adjuvants are currently the most widely used for human vaccines. However, concerns about their safety, such as local irritation at vaccination site and potential neurotoxicity, have been raised over recent years. Herein, bilayer microneedles fabricated using commercially available materials a simple micromolding preparation method in differential dual‐release manner sustained antigen release outer layer, fast of aluminum inner layer. The layer here replaces to form an...
Ulcerative colitis (UC) is a chronic and relapsing inflammatory disease of the intestine. Dysbiosis, especially expansion facultative anaerobic Enterobacteriaceae, maybe main pathogenesis UC. Gegen Qinlian decoction (GD), traditional Chinese medicinal formula chronicled in Shang Han Lun, commonly used to treat UC has shown an excellent effect on inducing remission. However, role GD regulating gut microbiota not been fully clarified. Herein, we investigated potential inhibiting...