A5069439091- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Adaptive Control of Nonlinear Systems
- Ferroptosis and cancer prognosis
- Adaptive Dynamic Programming Control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Distributed Control Multi-Agent Systems
- Pulmonary Hypertension Research and Treatments
- Boron and Carbon Nanomaterials Research
- Advanced ceramic materials synthesis
- Circular RNAs in diseases
- Cerebrovascular and Carotid Artery Diseases
- Robotic Path Planning Algorithms
- Nuclear Materials and Properties
- Graphene research and applications
- Nanoparticle-Based Drug Delivery
- UAV Applications and Optimization
- Aerospace and Aviation Technology
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Diamond and Carbon-based Materials Research
- Machine Fault Diagnosis Techniques
- Rheumatoid Arthritis Research and Therapies
- Genetic Syndromes and Imprinting
Ningbo Medical Center Lihuili Hospital
2016-2025
Ningbo University
2016-2025
Northwestern Polytechnical University
2021-2025
Zhejiang University
2019-2024
Xi'an Aeronautical University
2023
National Natural Science Foundation of China
2022
Weatherford College
2022
The Sixth People's Hospital of Shenyang
2021
The transfer of mitochondria between cells has recently been revealed as a spontaneous way to protect the injured cells. However, utilization this natural process for disease treatment is so far limited by its unsatisfactory efficiency and selectivity. Here, we demonstrate that iron oxide nanoparticles (IONPs) can augment intercellular mitochondrial from human mesenchymal stem (hMSCs) selectively diseased cells, owing enhanced formation connexin 43–containing gap junctional channels...
The use of exogenous mitochondria to replenish damaged has been proposed as a strategy for the treatment pulmonary fibrosis. However, success this is partially restricted by difficulty supplying sufficient diseased cells. Herein, we report generation high-powered mesenchymal stem cells with promoted mitochondrial biogenesis and facilitated transfer injured lung sequential pioglitazone iron oxide nanoparticles. This highly efficient shown not only restore homeostasis but also reactivate...
Over the last decade, researchers have paid more and attention to natural compound curcumin for its potential application in anticancer therapy. However, of has been limited owing rapid metabolism body. HO-3867, a stable analog, shows potent antitumor activities against various tumor cells. Yet, information on HO-3867's impact non-small-cell lung cancer (NSCLC) cells is lacking. Herein, we evaluated cytotoxicity HO-3867 NSCLC We discovered that suppressed viability containing wild-type p53....
Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation-related oncogene tumorigenic processes.We used viability assays, western blotting, immunofluorescence, transwell-matrigel invasion assay, wound-healing assay combined GC7 (a novel inhibitor) treatment or siRNA interference investigate the role of playing NSCLC chemotherapy.We found low...
Abstract Aluminum adjuvants are currently the most widely used for human vaccines. However, concerns about their safety, such as local irritation at vaccination site and potential neurotoxicity, have been raised over recent years. Herein, bilayer microneedles fabricated using commercially available materials a simple micromolding preparation method in differential dual‐release manner sustained antigen release outer layer, fast of aluminum inner layer. The layer here replaces to form an...
Glucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Variants gene were shown be associated with type 2 diabetes (T2D) and coronary heart disease (CHD). The goal this study was investigate the contribution gene-body methylation risk CHD.36 patients (18 males 18 females) 36 age- sex-matched controls collected for current research. DNA level CpG island (CGI) region on measured through sodium bisulfite conversion pyrosequencing...
The tumor immune microenvironment of lung cancer is associated with prognosis and immunotherapy efficacy. Long noncoding RNAs are identified as prognostic biomarkers functions. We constructed a signature comprising differentially expressed immune-related lncRNAs to predict the patients adenocarcinoma. established lncRNA by pairing regardless expression level adenocarcinoma were divided into high- low-risk groups. in two groups was significantly different; could serve an independent...
We determined the role of microRNA (miR)-9 in regulating cisplatin chemoresistance nonsmall cell lung cancer (NSCLC) cells. miR-9 and eukaryotic translation initiation factor 5A2 (eIF5A2) levels were examined by reverse transcription–quantitative PCR. Cell Counting Kit-8 5-ethynyl-2′-deoxyuridine (EdU) assay used to determine effects mimic or inhibitor on NSCLC proliferation viability, respectively. Bioinformatics was analyze relationship between eIF5A2. Flow cytometry percentage apoptotic...
Autophagy is closely associated with the tumor immune microenvironment (TIME) and prognosis of patients lung adenocarcinoma (LUAD). In present study, we established a signature on basis long noncoding RNAs (lncRNAs) related to autophagy (ARlncRNAs) investigate TIME survival LUAD. We selected ARlncRNAs construct model divided each sample into different groups risk score. The ARlncRNA could be recognized as an independent prognostic factor for LUAD, in low-risk group had greater advantage....
As an important non-apoptotic cell death method, oncosis has been reported to be closely associated with tumors in recent years. However, few research the relationship between and lung cancer.In this study, we established oncosis-based algorithm comprised of cluster grouping a risk assessment model predict survival outcomes related tumor immunity patients adenocarcinomas (LUAD). We selected 11 oncosis-related lncRNAs prognosis (CARD8-AS1, LINC00941, LINC01137, LINC01116, AC010980.2,...
For a quadrotor unmanned aerial vehicle (UAV), this paper proposes an adaptive sliding mode control (SMC) strategy enhanced with disturbance observer to attain precise trajectory and attitude tracking performance while compensating for the detrimental impacts of actuator faults disturbances. First, SMC that utilizes integral surface is presented enhance fault-tolerance capabilities studied UAV against faults. In addition, further created compensate By integrating proposed designed observer,...
Unmanned aerial vehicles (UAVs) multi-area coverage-path planning has a broad range of applications in agricultural mapping and military reconnaissance. Compared to homogeneous UAVs, heterogeneous UAVs have higher application value due their superior flexibility efficiency. Nevertheless, variations performance parameters among can significantly amplify computational complexity, posing challenges solving the multi-region coverage path-planning problem. Consequently, this study studies...
The aim of the present study was to identify differentially methylated regions (DMRs) in patients with rheumatic heart disease and secondary pulmonary arterial hypertension (RHD-PAH). A genome-wide DNA methylation assay performed between 6 RHD-PAH healthy controls using an Illumina Infinium HumanMethylation450 BeadChip kit. Limma software package subsequently used significant DMRs. total 40 hypome-thylated 64 hypermethylated CpG sites were identified group control group. Gene Ontology Kyoto...
Valvular heart disease (VHD) is a common that affects blood flow. It usually requires surgery. complicated with pulmonary artery hypertension (VHD-PAH) may be lethal due to failure results from increased burden. important for these patients seek early treatment in order minimize the damage. However, there no reliable diagnosis method VHD. In this study, we found DNA methylation was at promoter of BMPR2 gene VHD compared healthy controls. This finding confirmed by an independent cohort study...
To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated characterization. The function miRNA-1183 RHD using miRNA mimic on PBMCs and THP-1 cell models. binding Bcl-2 was confirmed by luciferase activity test. We also measured expression levels BCL-2 valve tissue from ELISA immunohistochemistry. In silico analysis...
Currently, the diagnosis and outcome of rheumatic valvular heart disease (RVHD) are less than ideal, there no accurate biomarkers. Circular RNA (circRNA) might participate in occurrence development RVHD.We use circRNA microarray to filter out target has_circ_0000437. qRT-PCR was used measure expression levels hsa_circ_0000437 RVHD plasma samples. We assessed diagnostic value RVHD. Cell function vitro experiment explore effect has_circ_0000437 on RVHD.Has_circ_0000437 is highly expressed (p <...