A5034728007- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Fluoride Effects and Removal
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
- Esophageal Cancer Research and Treatment
- Autophagy in Disease and Therapy
- Lung Cancer Diagnosis and Treatment
- Bone and Dental Protein Studies
- RNA Research and Splicing
- Arsenic contamination and mitigation
- Nanoplatforms for cancer theranostics
- Tracheal and airway disorders
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Renal and related cancers
- Metastasis and carcinoma case studies
Ningbo Medical Center Lihuili Hospital
2016-2025
Ningbo University
2016-2025
Hunan University of Humanities, Science and Technology
2023
China Institute of Atomic Energy
2023
National Natural Science Foundation of China
2022
Weatherford College
2022
First Affiliated Hospital Zhejiang University
2018-2019
Peking University
2009-2018
National Institute for Communicable Disease Control and Prevention
2018
Chinese Center For Disease Control and Prevention
2008-2016
Migrasomes, recently discovered cellular substructures, may play a crucial role in cancer progression, treatment response, and prognosis. However, the prognostic value of migrasome-associated long non-coding RNAs (lncRNAs) colon adenocarcinoma (COAD) remains unexplored. RNA-seq data from 459 COAD patients, including clinical characteristics outcome information, were obtained The Cancer Genome Atlas. A risk model was constructed through co-expression analysis migrasome genes lncRNAs, followed...
Abstract Hypoxia-induced cisplatin resistance is a major challenge during non-small cell lung cancer (NSCLC) treatment. Based on previous studies, we further explored the effect of eukaryotic initiation factor 5A2 (eIF5A2) in hypoxia-induced resistance. In this study, found that autophagy and were increased under hypoxic conditions three different NSCLC lines. Compared with normoxic conditions, dramatic upregulation eIF5A2 hypoxia inducible 1 subunit alpha (HIF-1α) levels detected exposure....
The standard treatment for pulmonary neuroendocrine neoplasms (pNENs) is surgery in the early stage and generally determined according to histologic type stage. Radiotherapy (RT) a option locally advanced or unresectable lung cancers. aim of this study was determine prognostic value RT patients with pNENs using data from Surveillance, Epidemiology, End Results database. We used propensity score matching analysis balance differences variables between no-RT groups. Univariate multivariate Cox...
Radiotherapy is a key treatment for colorectal cancer (CRC), particularly rectal cancer; however, many patients are resistant to radiation. While it has been shown that CHI3L1 associated with CRC progression, its specific function and regulatory mechanisms in radiation resistance remain unclear. The levels of normal tissue samples were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets. To assess the effects on cell proliferative, migratory, invasive capacities,...
Objective To study the effects of saikosaponin D (SSD) on proliferation and apoptosis in human non-small cell lung cancer lines, to explore underlying mechanisms. Methods Following treatment with D, A549 H1299 cells were assessed for anti-proliferation using cycle kit-8 assays, changes nuclear morphology 4′,6-diamidino-2-phenylindole (DAPI) staining, annexin V/propidium iodide double staining. Proliferation- apoptosis-related proteins detected by immunoblotting. Results Saikosaponin had...
Abstract Radiotherapy serves as a crucial strategy in the treatment of colorectal cancer (CRC). However, its efficacy is often hindered by challenge radiation resistance. Although literature suggests that some tRNA‐derived small RNAs (tsRNAs) are associated with various cancers, studies reporting relationship tsRNAs cell radiosensitivity have not been published yet. In our study, we utilized sequencing to predict differentially expressed two CRC cells and their radioresistant cells, 10...
Long non-coding RNAs (lncRNAs) have been reported to be prognostic factors for cancer. Ferroptosis is an iron-dependent process of programmed cell death. Here, we established a ferroptosis-related lncRNA (frlncRNA) pair signature and revealed its value in colon adenocarcinoma (COAD) by analyzing the data from The Cancer Genome Atlas (TCGA). FrlncRNAs were identified based on co-expression analysis using Pearson correlation. Differentially expressed frlncRNAs (DEfrlncRNAs) recognized paired,...
Spindle and kinetochore‑associated protein 2 (SKA2) is essential for regulating the progression of mitosis. In recent years, SKA2 upregulation has been detected in various human malignancies role tumorigenesis received increasing attention. However, expression functional significance breast cancer are not completely understood. To study effects on cancer, levels tissues cell lines were evaluated by western blotting, reverse transcription‑quantitative polymerase chain reaction...
Emerging evidence shows that the aberrantly expressed cyclic AMP responsive element-binding protein (CREB) is associated with tumor development and progression in several cancers. Spindle kinetochore-associated 2 (SKA2) essential for regulating progress of mitosis. In this study, we evaluate vitro vivo functional relationship between CREB SKA2 renal cell carcinoma (RCC). Suppressing replenishing levels were used to manipulate expression, observing effects on RCC lines. Computational...
Background: SLC20A1, a prominent biomarker in several cancers, has been understudied its predictive role head and neck squamous cell carcinoma (HNSCC). Methods: The Cancer Genome Atlas (TCGA) database was used to analyze HNSCC prognosis, SLC20A1 overexpression, clinical characteristics. Quantitative real-time PCR Western blot analysis confirmed expression tissues. Cellular behaviors such as invasion, migration proliferation were assessed using Transwell, wound healing colony formation...
The tumor immune microenvironment of lung cancer is associated with prognosis and immunotherapy efficacy. Long noncoding RNAs are identified as prognostic biomarkers functions. We constructed a signature comprising differentially expressed immune-related lncRNAs to predict the patients adenocarcinoma. established lncRNA by pairing regardless expression level adenocarcinoma were divided into high- low-risk groups. in two groups was significantly different; could serve an independent...
To identify the 20 most important and preventable health problems that should be addressed in next years China.In 2015, we applied a modified electronic Delphi technique to reach consensus from panel of top Chinese experts (n = 70), who were requested that, their judgment, preventable. We also compared results with evidences epidemiological studies on disease-specific mortalities disability-adjusted life years.Consensus was reached after second-round survey. The final agreed-upon included 9...
Abstract Background Chitinase 3‐like protein 1 (CHI3L1) is most likely a malignant tumor metastasis‐associated gene. However, the functions of CHI3L1 in colon cancer cell proliferation and its cetuximab sensitivity are still unclear. We aimed to investigate mechanism promoting cetuximab. Methods The expression adjacent tissues were detected by immunohistochemistry. was overexpressed lines lentiviral technology. Cell measured MTT assay, cycle analyzed flow cytometry, cycle‐related proteins...
The FXYD gene family comprises seven members that encode a class of small-membrane proteins characterized by an motif and interact with Na+/K+-ATPase. Until now, the expression patterns prognostic roles in colon cancer (CC) have not been systematically reported. Gene expression, methylation, clinicopathological features prognoses CC patients were obtained from Cancer Genome Atlas (TCGA) database. feature values identified. set enrichment analysis (GSEA) was performed to explore potential...
Autophagy is closely associated with the tumor immune microenvironment (TIME) and prognosis of patients lung adenocarcinoma (LUAD). In present study, we established a signature on basis long noncoding RNAs (lncRNAs) related to autophagy (ARlncRNAs) investigate TIME survival LUAD. We selected ARlncRNAs construct model divided each sample into different groups risk score. The ARlncRNA could be recognized as an independent prognostic factor for LUAD, in low-risk group had greater advantage....
As an important non-apoptotic cell death method, oncosis has been reported to be closely associated with tumors in recent years. However, few research the relationship between and lung cancer.In this study, we established oncosis-based algorithm comprised of cluster grouping a risk assessment model predict survival outcomes related tumor immunity patients adenocarcinomas (LUAD). We selected 11 oncosis-related lncRNAs prognosis (CARD8-AS1, LINC00941, LINC01137, LINC01116, AC010980.2,...
The purpose of this study was to conduct a matched-pair analysis assess the impact radiotherapy (RT) on patients with malignant tracheal tumors using surveillance, epidemiology, and end results database. Additionally, predictive nomogram developed for tumors.Propensity score matching (PSM) used minimize bias between RT no-RT groups. We utilized both univariate multivariate Cox proportional hazards regression analyses identify independent prognostic factors subgroups. novel evaluated its...