A5101617851- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Retinal Development and Disorders
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Sphingolipid Metabolism and Signaling
- Drug-Induced Hepatotoxicity and Protection
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Liver physiology and pathology
- PI3K/AKT/mTOR signaling in cancer
- Glycosylation and Glycoproteins Research
- Phagocytosis and Immune Regulation
- Neuroscience and Neuropharmacology Research
- Peroxisome Proliferator-Activated Receptors
- Cancer Mechanisms and Therapy
- Advanced Glycation End Products research
- Endoplasmic Reticulum Stress and Disease
- Hepatitis C virus research
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Virology and Viral Diseases
Xinxiang Medical University
2007-2025
Capital Medical University
2007-2023
Beijing YouAn Hospital
2014-2023
Second Xiangya Hospital of Central South University
2012-2023
Central South University
2012-2023
First Affiliated Hospital of Xinxiang Medical University
2022
Ningbo Medical Center Lihuili Hospital
2011-2020
Beijing Institute of Neurosurgery
2016
Centre National de la Recherche Scientifique
1992-2016
Institut National des Sciences Appliquées Rouen Normandie
2016
Ulcerative colitis (UC) is a recurrent inflammatory disease without specific cure or treatment for improvement. Here, we investigated the potential therapeutic effect and mechanism of ginsenoside Rg3 (Gin Rg3) on UC. We constructed an in vitro cellular model dextran sulfate sodium (DSS)-induced UC mouse model. also used Gin Rg3, MCC950 (NLRP3 inhibitor), MSU activator), fecal transplantation (FMT) to intervene The results showed that inhibited NLRP3 inflammasome activation, pyroptosis,...
Background: Mesenchymal stem cell (MSC)-derived exosomes (Exos) are recently proved to be a promising candidate for ulcerative colitis (UC), but the mechanism remains unclear. We investigated effects of MSC-derived exosomal microRNA-181a (miR-181a) on gut microbiota, immune responses, and intestinal barrier function in UC. Methods: Human bone marrow Exos were extracted identified via transmission electron microscopy (TEM), Nanoparticle Tracking Analysis (NTA), Western blotting. Dextran...
Background & Aims Hepatitis delta virus (HDV) infection accelerates the progression of chronic hepatitis B (HBV) infection, posing a large economic and health burden to patients. At present, there remains lack accurate portable detection methods for HDV RNA. Here, we aim establish convenient, rapid, highly sensitive specific method detect RNA using CRISPR–Cas13a technology.
Abstract Metabolic alteration is a hallmark of cancer. Dysregulation methionine metabolism implicated in human liver Methionine adenosyltransferase IIα (MAT IIα) key enzyme the cycle, catalysing production S -adenosylmethionine (SAM), methyl donor cellular processes, and associated with uncontrolled cell proliferation Here we show that P300 acetylates MAT at lysine residue 81 destabilizes by promoting its ubiquitylation subsequent proteasomal degradation. Conversely, histone deacetylase-3...
The HER2-targeting antibody trastuzumab has shown effectiveness in treating HER2-positive breast and gastric cancers; however, its responses are limited. Currently, Nrf2 been deemed as a key transcription factor promoting cancer progression resistance by crosstalk with other proliferative signaling pathways. Brusatol novel inhibitor an efficacious safe drug candidate therapy. In this study, we firstly reported that brusatol exerted the growth-inhibitory effects on cells regressing Nrf2/HO-1...
A micrometer-sized spherical particle classically equilibrates at the water–air interface in partial wetting configuration, causing about no deformation to interface. In condition of thermal equilibrium, just undergoes faint Brownian motion, well visible under a microscope. We report experimental observations when is made light-absorbing material and heated up by vertical laser beam. show that, small power, trapped on-axis similarly 2-dimensional trapping transparent sphere optical forces....
Objective To study the effects of saikosaponin D (SSD) on proliferation and apoptosis in human non-small cell lung cancer lines, to explore underlying mechanisms. Methods Following treatment with D, A549 H1299 cells were assessed for anti-proliferation using cycle kit-8 assays, changes nuclear morphology 4′,6-diamidino-2-phenylindole (DAPI) staining, annexin V/propidium iodide double staining. Proliferation- apoptosis-related proteins detected by immunoblotting. Results Saikosaponin had...
MicroRNAs (miRs), a class of small noncoding RNAs, are important regulators for gene expression through directly binding to the 3′-untranslated region (3′-UTR) their target mRNA. Recently, downregulation miR-520b has been observed in several common human cancers. However, exact role colorectal cancer (CRC) not previously studied. In this study, our data showed that was significantly downregulated CRC and cell lines when compared with adjacent normal tissues intestinal epithelial line. Low...
The Qingchangligan formula, a traditional Chinese medicine comprising five herbs, is useful for treatment of patients with liver failure; however, its protective and regulatory mechanisms remain elusive. To test the hypothesis that formula protects mice against acute failure by inhibiting inflammation. Acute (ALF) was induced intraperitoneal injection D-GalN (700 mg/kg) plus LPS (10 μg/kg). administered to in three doses 50 mg/kg (on day 1, 2, 3) prior D-GalN/LPS intragastric administration....
A palladium-catalyzed reaction of homoallyl alcohols with propargylic carbonates was realized via oxidative addition/decarboxylation/retro-allylation.
Hepatocyte apoptosis and energy metabolism in mitochondria have an important role the mechanism of acute liver failure (ALF). However, data on association between hepatocytes are lacking. The current study assessed activity several key enzymes during ALF, including citrate synthase (CS), carnitine palmitoyltransferase‑1 (CPT‑1) cytochrome c oxidase (COX), which involved hepatocyte metabolism. A total 40 male Sprague‑Dawley rats were divided into five groups administered D‑galactosamine...
ObjectiveTo explore the relation between serum sphingolipids and hepatic injury in chronic HBV infection.MethodsA cohort of participants including 48 healthy persons, 103 HBV-infected patients containing hepatitis B (CHB) HBV-related cirrhosis were included. High performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) was performed detect sphingolipids. The serological indicators detected quantified. valid liver biopsy specimens acquired from twenty five...
Our previous study found that glucosylceramide, a type of sphingolipids, was associated with liver inflammation and fibrosis. Glucosylceramide is generated by glucosylceramide synthase (GCS), which encoded the UDP‑glucose ceramide glucosyltransferase (UGCG) gene. GCS key enzyme to regulate physiological activity cells. However, role in hepatic cells remains unclear. The aim present explore mechanism proliferation apoptosis Following interference expression vitro UGCG small interfering...
Accurate estimation of hepatic necroinflammation caused by chronic hepatitis C (CHC) is crucial for prediction prognosis and design therapeutic strategy, which particularly true CHC patients with normal alanine aminotransferase (ALT) level. Recent studies have shown that sphingolipids a close relationship virus infection. The present study aimed to identify plasma related necroinflammation. We included 120 treatment-naïve 64/120 had ALT levels (<40 U/L). who underwent liver biopsies were...
Previously, we developed a novel EGFR-targeted antibody (denoted as Pan), which has superior antitumor activity against EGFR-overexpressed tumors. However, it shows marginal effect on the growth of esophageal cancers. Therefore, variable region Pan was fused to fragment Pseudomonas exotoxin A (PE38) create immunotoxin, denoted Ptoxin (PT). Results indicated that PT more effective compared with both KYSE-450 and KYSE-150 cancer cells, especially cells. Moreover, treatment induces regression...
Abstract KIF18A belongs to the kinesin-8 subfamily and is a plus-end-directed motor, which regulates kinetochore microtubules dynamics control mitotic chromosome alignment spindle tension. Studies have shown that genetic depletion or pharmacological inhibition of promising therapeutic approach for cancers, exhibiting high chromosomal instability (CIN-high), without having significant impact on normal division euploid cells. Here, we report discovery preclinical evaluation ISM9682A, novel...
The plasma profile of sphingolipids in hepatic fibrosis patients with chronic hepatitis C (CHC) is rarely considered at present. association between and severe CHC remains an obscure area research. aim the present study was to assess examine CHC, order identify potential novel markers CHC. A cohort 120 treatment‑naïve were included study. Liver biopsies performed routine serological indicators measured. Plasma detected using high performance liquid chromatography tandem mass spectrometry....