A5046491022- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- MRI in cancer diagnosis
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Medical Imaging Techniques and Applications
- Hepatitis B Virus Studies
- Turfgrass Adaptation and Management
- Cancer, Hypoxia, and Metabolism
- Gallbladder and Bile Duct Disorders
- Cancer Research and Treatments
- Advanced MRI Techniques and Applications
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Soybean genetics and cultivation
- Hepatitis C virus research
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Xinxiang Medical University
2023-2025
Shanghai East Hospital
2020-2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Université Paris Cité
2023-2024
Hamilton Health Sciences
2024
AGH University of Krakow
2024
University of Ottawa
2024
This study was performed to prospectively develop and validate a radiomics nomogram for predicting postoperative early recurrence (≤1 year) of hepatocellular carcinoma (HCC) using whole-lesion features on preoperative gadoxetic acid-enhanced magnetic resonance (MR) images.In total, 155 patients (training cohort: n = 108; validation 47) with surgically confirmed HCC were enrolled in this IRB-approved prospective study. Three-dimensional regions interest manually delineated along the tumour...
Microvascular invasion (MVI) is an important risk factor in hepatocellular carcinoma (HCC), but its diagnosis mandates postoperative histopathologic analysis. We aimed to develop and externally validate a predictive scoring system for MVI.From July 2015 November 2020, consecutive patients underwent surgery HCC with preoperative gadoxetate disodium (EOB)-enhanced MRI was retrospectively enrolled. All MR images were reviewed independently by two radiologists who blinded the outcomes. In...
Background Peritumoral hepatobiliary phase (HBP) hypointensity is an established prognostic imaging feature in hepatocellular carcinoma (HCC), often associated with microvascular invasion (MVI). Similar features are needed for non-HBP MRI. Purpose To propose a non-hepatobiliary-specific MRI tool similar value to peritumoral HBP hypointensity. Materials and Methods From December 2011 November 2021, consecutive patients HCC who underwent preoperative contrast-enhanced were retrospectively...
ABSTRACT Background & Aims Microvascular invasion (MVI) is associated with poor prognosis in hepatocellular carcinoma (HCC). Topology may improve the predictive performance and interpretability of deep learning (DL). We aimed to develop externally validate an MRI‐based topology DL model for preoperative prediction MVI. Methods This dual‐centre retrospective study included consecutive surgically treated HCC patients from two tertiary care hospitals. Automatic liver tumour segmentations...
The aim of this study was to prospectively evaluate the diagnostic efficacy diffusion kurtosis imaging (DKI) in predicting microvascular invasion (MVI) and histologic grade hepatocellular carcinoma (HCC) with comparison conventional diffusion-weighted (DWI).This prospective approved by Institutional Review Board, written informed consent obtained from all patients. From September 2015 January 2017, 74 consecutive HCC patients were enrolled study. Preoperative magnetic resonance including DKI...
Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). Preknowledge MVI would assist tailored surgery planning in HCC management. In this multicenter study, we aimed to explore the validity deep learning (DL) prediction using two imaging modalities—contrast-enhanced computed tomography (CE-CT) and gadoxetic acid-enhanced magnetic resonance (EOB-MRI). A total 750 HCCs were enrolled from five Chinese tertiary hospitals....
Abstract Intrahepatic cholangiocarcinoma (iCCA) is the second most prevalent primary liver cancer. Although genetic characterization of iCCA has led to targeted therapies for treating tumors with FGFR2 alterations and IDH1/2 mutations, only a limited number patients can benefit from these strategies. Epigenomic profiles have emerged as potential diagnostic prognostic biomarkers improving treatment cancers. In this study, we conducted whole-genome bisulfite sequencing on 331 iCCAs integrated...
PurposeTo investigate whether Liver Imaging Reporting and Data System (LI-RADS) imaging features at preoperative gadoxetic acid-enhanced MRI can predict microvascular invasion (MVI) histologic grade of hepatocellular carcinoma (HCC) to evaluate their associations with recurrence after curative resection single HCC.Materials methodsFrom July 2015 September 2018, 111 consecutive patients pathologically confirmed HCC who underwent acid–enhanced within 1 month before surgery were included in...
The Liver Imaging Reporting and Data System (LI-RADS) European Association for the Study of (EASL) criteria are widely used diagnosing hepatocellular carcinoma (HCC). Radiomics allows further quantitative tumor heterogeneity profiling. This study aimed to compare diagnostic accuracies version 2018 (v2018) EASL, LI-RADS radiomics models HCC in high-risk patients. Ethical approval by institutional review board informed consent were obtained this study. From July 2015 September 2018,...
Abstract Objectives To explore the role of preoperative gadoxetic acid–enhanced MRI in stratifying risk early recurrence patients with LR-5 hepatocellular carcinoma (HCC) by LI-RADS v2018 after curative resection. Methods Between July 2015 and August 2018, this study evaluated consecutive treatment-naïve at-risk HCC who underwent examination within 2 weeks before The Cox regression analysis was performed to identify potential predictors recurrence. Disease-free survival (DFS) rates were...
We aimed to develop a noninvasive artificial intelligence (AI) model diagnose signet-ring cell carcinoma (SRCC) of gastric cancer (GC) and identify patients with SRCC who could benefit from postoperative chemotherapy based on preoperative contrast-enhanced computed tomography (CT).A total 855 GC single GCs were included, which 249 diagnosed as by histopathologic examinations. The AI was generated clinical, handcrafted radiomic, deep learning features. Model diagnostic performance measured...
Background Identifying patients at high risk for advanced-stage hepatocellular carcinoma (HCC) recurrence after liver resection may improve patient survival. Purpose To develop a model including MRI features predicting postoperative HCC recurrence. Materials and Methods This single-center, retrospective study includes consecutive adult who underwent preoperative contrast-enhanced curative-intent early- to intermediate-stage (from December 2011 April 2021). Three radiologists evaluated 52...
Colorectal cancer (CRC) is the most common gastrointestinal malignancy, and 5-Fluorouracil (5-FU) principal chemotherapeutic drug used for its treatment. However, 5-FU resistance remains a significant challenge. Under stress conditions, tumor metabolic reprogramming influences resistance. Serine metabolism plasticity one of crucial pathways influencing in CRC. mechanisms by which CRC modulates serine under serine-deprived conditions remain unknown. We found that exogenous deprivation...
Background: Glioblastoma (GBM), a common type of brain tumor, is currently treatable through radiation therapy. However, there room for improvement in the effec-tiveness treatment. Radiation can lead to an increase expression PD-L1 and VEGF, which might reduce responsiveness tumor This situation underlines necessity innovative treatment strategies. Objectives: In this study, we investigated potential attenuated Salmonella carrying co-expressing plasmid siPD-L1-Endo effectively inhibit VEGF...
Abstract Background Venous thrombosis represents a significant complication after deceased-donor liver transplantation, yet there are currently no established protocols for thromboprophylaxis transplantation. The aim of this study was to evaluate the efficacy and safety prophylactic anticoagulation in patients undergoing Methods A dual-centre RCT assigned receive either enoxaparin or normal saline transplantation conducted. primary outcome incidence venous (portal vein deep thrombosis) major...