A5052801053- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- FOXO transcription factor regulation
- Cancer Research and Treatments
- Kruppel-like factors research
- RNA Research and Splicing
- Mesenchymal stem cell research
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Cutaneous Melanoma Detection and Management
- PI3K/AKT/mTOR signaling in cancer
- Molecular Biology Techniques and Applications
- Autophagy in Disease and Therapy
- Immune cells in cancer
Shanghai East Hospital
2019-2025
Huazhong Agricultural University
2025
National University of Singapore
2023
Singapore Immunology Network
2023
Agency for Science, Technology and Research
2023
The University of Texas Medical Branch at Galveston
2019-2023
Tongji University
2021
Fudan University
2015-2019
Zhongshan Hospital
2015-2019
The First Affiliated Hospital, Sun Yat-sen University
2015-2017
The aim of this study is to evaluate the long-term outcomes a large series patients treated with submucosal tunneling endoscopic resection (STER).STER newly developed treatment for upper gastrointestinal tumors originating from muscularis propria layer. Recently, reports about STER are increasing, but follow-up little known.In retrospective study, total 180 undergoing were included June 2011 May 2013. Clinicopathological, endoscopic, and data collected analyzed.The en bloc was achieved in...
<b>Background and study aims: </b>Submucosal tunneling endoscopic resection (STER) has become a potential option for the treatment of selected group patients with submucosal tumors (SMTs) originating from muscularis propria layer in upper gastrointestinal tract. The aim this retrospective was to analyze incidence management STER-related complications. <b>Patients methods: </b>From January 2011 August 2013, 290 SMTs treated by STER were included study. Clinicopathological characteristics...
Cisplatin (DDP)-based chemotherapy is commonly adopted as the first-line treatment for patients with oesophageal squamous cell carcinoma (OSCC), but high rate of drug resistance limits its clinical application and underlying mechanisms at play remain unclear. The aims this study were to elucidate role abnormal signal transmission metabolism in chemoresistance OSCC under hypoxia identify targeted drugs that enhance sensitivity DDP chemotherapy.Upregulated genes determined by RNA sequencing...
Colorectal cancer (CRC) is the most common gastrointestinal malignancy, and 5-Fluorouracil (5-FU) principal chemotherapeutic drug used for its treatment. However, 5-FU resistance remains a significant challenge. Under stress conditions, tumor metabolic reprogramming influences resistance. Serine metabolism plasticity one of crucial pathways influencing in CRC. mechanisms by which CRC modulates serine under serine-deprived conditions remain unknown. We found that exogenous deprivation...
A 48-year-old woman underwent a colonoscopy at our hospital for routine screening. During the procedure, suspicious fistula was identified in descending colon ([Fig. 1]), with brown metallic foreign body visible opening as endoscope approached 2]). We grasped exposed end of biopsy forceps and slowly pulled it into intestinal lumen great caution ([Video 1]). Finally, successfully removed without any active bleeding confirmed to be an intrauterine device (IUD) 3]).
Chinese milk vetch (CMV), as a typical green manure in southern China, plays an important role improving soil quality and partially substituting nitrogen chemical fertilizers for rice production. Accurately estimating the aboveground biomass (AGB) of CMV is crucial quantifying biological fixation amount (BNFA) assessing its viability fertilizer alternative. However, traditional estimation methods have low efficiency field-scale evaluations. Recently, unmanned aerial vehicle (UAV) remote...
Background There remain concerns regarding the technical feasibility of endoscopic resection for large gastrointestinal stromal tumors (GISTs), mainly relating to risk tumor rupture and adequacy margins. This study aimed evaluate therapeutic outcomes newly developed no-touch full-thickness (NT-EFTR) technique GISTs. Methods In this retrospective study, 92 patients with gastric GISTs undergoing NT-EFTR were included. Clinicopathological, endoscopic, follow-up data collected analyzed. Results...
Homeobox A7 (HOXA7) plays essential roles in multiple malignancies and was reported to be overexpressed esophageal squamous cell carcinoma (ESCC). However, its functions the ESCC tumor microenvironment remain explored. In this study, we showed that HOXA7 among HOXA family members correlated with tumor-associated macrophage (TAM) infiltration both The Cancer Genome Atlas database clinical samples. Moreover, transactivation of C-C motif chemokine ligand 2 (CCL2) by identified (real-time...
Abstract Purpose Esophageal squamous cell carcinoma (ESCC) is an aggressive disease with a poor prognosis, caused by the inactivation of critical growth regulators that lead to uncontrolled proliferation and increased malignancy. Although Serine/Threonine Kinase 3 (STK3), also known as Mammalian STE20-like protein kinase 2 (MST2), highly conserved Hippo pathway, plays role in immunomodulation, organ development, cellular differentiation, cancer suppression, its phenotype function ESCC...
With the advancement in endoscopic technology, discovery of novel techniques such as full-thickness resection (EFTR) provides new contents for natural orifice transluminal surgery (NOTES) and therapeutic options patients with gastrointestinal lesions. Here, we present transcolonic appendectomy an expansion full thickness extraluminal dissection appendix minimally invasive treatment sessile serrated lesions (SSLs) deeply involving appendiceal orifice; final closure is done by endoloop clip...
Esophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) main upregulated ESCC. The results immunohistochemistry show ELF4 overexpressed tissues significantly correlated with cancer staging...
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers because its robust aggressive phenotype and chemoresistance. TAO kinase belongs to mitogen-activated protein kinases, which mediate drug resistance in multiple cancers. However, role ESCC progression chemoresistance has never been explored. Here, it reported that TAOK3 augments autophagy further promotes Mechanistically, phosphorylates KMT2C at S4588 strengthens interaction between ETV5. Consequently, nuclear...
Ras‑associated protein 1A (Rap1A) is a member of the Ras subfamily small GTP‑binding proteins and found to promote metastasis in several types cancer. However, functional role molecular mechanism action Rap1A esophageal squamous cell carcinoma (ESCC) not fully understood. In present study, was be upregulated ESCC tissues its expression correlated with cancer stage. Functional studies revealed that could by stimulating migration invasion vivo vitro. Further study indicated transcriptional...
Background: Cancer cells survive and develop under nutrient deficient microenvironment caused by low blood supply.Although anaerobic metabolism could function through the enhanced uptake of glucose, other mechanisms tolerance to glucose conditions might be required.Materials Methods: Expression asparagine synthetase (ASNS) normal glucose-deprived was examined.Cancer cell proliferation migration were evaluated in vitro vivo assays.In addition, relationship between ASNS expression cancer...
Abstract Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member forkhead box (FOX) family, FOXC1, assumes significance embryonic development organogenesis. Furthermore, FOXC1 functions as an overexpressed transcription factor various tumors, fostering proliferation, enhancing migratory capabilities, promoting resistance, while maintaining stem-cell-like properties. Despite these implications, scant attention has been...
The clinical spectrum of acute diverticulitis ranges from a phlegmon to limited abscesses, free perforation with purulent or contaminated peritonitis [1]. While there is little debate about the optimal treatment for mild very severe situations, uncertainty remains strategy localized abscesses. Here, we report successful endoscopic diverticulotomy septic caused by fecal stone.
Transcription factor 3 (TCF3) is a member of the basic Helix - Loop (bHLH) transcription (TF) family and encoded by TCF3 gene (also known as E2A). It has been shown that functions key in pathogenesis several human cancers plays an important role stem cell maintenance carcinogenesis. However, effect progression esophageal squamous carcinoma (ESCC) poorly known. In our study, was found to express highly correlated with cancer stage prognosis. promote ESCC invasion, migration, drug resistance...