A5018324670- Gastric Cancer Management and Outcomes
- Mycotoxins in Agriculture and Food
- Selenium in Biological Systems
- Heme Oxygenase-1 and Carbon Monoxide
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Inflammasome and immune disorders
- Alcohol Consumption and Health Effects
- CRISPR and Genetic Engineering
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Agricultural Systems and Practices
- Osteoarthritis Treatment and Mechanisms
- Insect Resistance and Genetics
- Reconstructive Surgery and Microvascular Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
University of Chinese Academy of Sciences
2025
Chinese Academy of Sciences
2013-2025
Shenzhen Institutes of Advanced Technology
2023-2025
Chongqing Jiaotong University
2024
Shanghai Academy of Agricultural Sciences
2021-2024
Ministry of Agriculture and Rural Affairs
2024
Shanghai Ocean University
2024
People’s Hospital of Rizhao
2019-2023
Nanjing Agricultural University
2019-2023
Hefei First People's Hospital
2022-2023
Abstract Aflatoxin B1 (AFB1) is a widespread contaminant in foods and feedstuffs, its target organ the liver. Melatonin (MT) has been shown to alleviate inflammation organs remodel gut microbiota animals humans. However, underlying mechanism by which MT alleviates AFB1‐induced liver injury remains unclear. In present study, pretreatment markedly increased expression of intestinal tight junction proteins (ZO‐1, Occludin, Claudin‐1), decreased permeability, reduced production gut‐derived...
BACKGROUND: LncRNA and microRNA play an important role in the development of human cancers; they can act as a tumor suppressor gene or oncogene. GAS5, originating from separation cDNA subtractive library, is c
Crop and aquatic animal co-culture systems have been used for over 1200 years can very efficiently utilize nutrients materials available in agroecology settings. These are sustainable forms of agriculture, extensively practiced worldwide. Microorganisms play critical roles promoting ecosystem nutrient transformations material circulations. However, the long-term effects this farming system on soil health microbial community stability, addition to their relationships with rice yields, remain...
The environmental impacts of genetically modified (GM) plants remain a controversial global issue. To address these issues, comprehensive risk assessments GM is critical for the sustainable development and application transgenic technology. In this paper, significant differences were not observed between microbial metagenomic metabolomic profiles in surface waters Bt rice (T1C-1, line) non-Bt cultivars (Minghui 63 (the isogenic Zhonghua 11 conventional japonica cultivar)). contrast, apparent...
To investigate whether melatonin has synergistic effects with doxorubicin in the growth-inhibition and apoptosis-induction of human hepatoma cell lines HepG2 Bel-7402.The synergism inhibited growth induced apoptosis Bel-7402. Cell viability was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. evaluated using TUNEL method flow cytometry. Apoptosis-related protein Bax, Bcl-2 caspase-3 expressions were measured immunohistochemical staining.Treatment...
We have recently identified miR-125b upregulation in glioblastoma (GMB). The aim of this study is to determine the correlation between expression and malignant grades glioma genes targeted by miR-125b. Real-time PCR was employed measure level Cell viability evaluated cell growth colony formation soft-agar assays. apoptosis determined Hoechst 33342 staining AnnexinV-FITC assay. Luciferase assay used confirm actual binding sites p38MAPK mRNA. Western blot detect gene level. positively...
ObjectiveObesity has become a global health issue and risk factor for hyperuricemia. However, the associations between obesity hyperuricemia are sometimes confounding. In present study, we performed mendelian randomization (MR) analysis to study their relationship investigate underlying mechanism by network pharmacology.MethodBody mass index (BMI) uric acid related single nucleotide polymorphism were selected as instrumental variables MR analysis. Three robust analytical methods used...
Aflatoxin B1 (AFB1) is a widespread mycotoxin in food and feed. Although the liver main target organ of AFB1, intestine first exposure to AFB1. However, mechanism by which AFB1 induced intestinal barrier dysfunction via regulating farnesoid X receptor (FXR)-mediated myosin light chain kinase (MLCK) signaling pathway has rarely been studied. In vivo, significantly decreased small length increased permeability. Meanwhile, markedly suppressed protein expressions FXR, ZO-1, occludin, claudin-1...
Mycotoxins are toxic metabolites produced by fungi, which ubiquitous in cereals and feed worldwide threaten human animal health. Deoxynivalenol (DON) is one of the most prevalent mycotoxins causes a series toxicities, especially enterotoxicity immunotoxicity. Porcine epidemic diarrhea virus (PEDV) destructive enteropathogenic coronavirus, often accompanied with DON contamination swine herd. Previous studies have shown that PEDV infection leads severe immunosuppression pigs. However, whether...
ABSTRACT Ovarian endometrioma (OEM), a particularly severe form of endometriosis, is an oestrogen‐dependent condition often associated with pain and infertility. The mechanisms by which OEM impairs fertility, through its direct impact on oocyte‐cumulus cell (CC) communication related pathways, remain poorly understood. This study investigates the oocyte‐CC explores melatonin's therapeutic potential. We used mouse model employed ovarian transcriptome gene set enrichment analyses to identify...
Mycotoxins are toxic metabolites produced by fungal species that commonly present in the global environment, especially cereals and animal forages. The changing environment may further increase exposure to these toxins, posing a serious threat humans animals. Recently, coronavirus has become one of most important pathogens threatening human health. It is not clear whether environmental such as mycotoxins, will affect infection. Given pigs among animals affected highly homologous humans,...
The toxicity of deoxynivalenol (DON) in healthy humans and animals has been extensively studied. However, whether the natural-low-dose DON is scatheless under unhealthy conditions, especially intestinal injury, unknown. Infection enterotoxigenic Escherichia coli (ETEC) a classical injury model. In this study, we explored effects low-dose on induced by ETEC infection underlying mechanism piglets, mice, IPEC-J2 monolayer cells. Results showed that significant growth slowdown, severe diarrhea,...
Cyclosporine A (CsA) extracted from the products of fungal fermentation is used to develop a chronic nephropathy model. However, it has numerous side effects. Ochratoxin (OTA) mycotoxin that induces renal injury. We developed model lessen effects CsA by administration nontoxic dosage OTA, and investigated underlying mechanism. C57BL/10 wild-type mice, toll-like receptor 4 (TLR4)-/- HK-2 cells were in this study. The (0.25 mg/kg, qod) OTA could significantly decrease 30 20 mg/kg per day,...
Background: Osteoarthritis (OA) is one of the most common degenerative joint diseases characterized by increased apoptosis and autophagy deficiency. The investigation was performed to examine effect valproic acid (VPA) molecular mechanism related miR-302d-3p/ITGB4 axis in OA. Methods: OA clinical samples were obtained from GEO database analyze differentially expressed genes. An vitro model mimicked LPS CHON-001 cells. Autophagy-related genes downloaded HADb website, potential drugs mined...
Fumonisin B1 (FB1) is a fungal metabolite, which has an incremental detection rate in grains and feed worldwide. The nucleotide-binding oligomerization domain-like pyrin domain containing protein 3 (NLRP3) inflammasome critical element pyroptosis activation, participates regulating enteritis. Meanwhile, autophagy also engaged intestinal inflammation. However, the function of FB1-mediated enterotoxicity remains unclear. In this study, we explored effects FB1 on enteritis underlying mechanism...