A5050650769- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Inflammasome and immune disorders
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- interferon and immune responses
- Gout, Hyperuricemia, Uric Acid
- Immune Response and Inflammation
- Trace Elements in Health
- Fungal Biology and Applications
- Microbial Metabolic Engineering and Bioproduction
- Marine Bivalve and Aquaculture Studies
- Aquaculture Nutrition and Growth
- Toxin Mechanisms and Immunotoxins
- Enzyme Structure and Function
- Autophagy in Disease and Therapy
- Polysaccharides and Plant Cell Walls
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- Toxoplasma gondii Research Studies
- Neuropeptides and Animal Physiology
- Carbohydrate Chemistry and Synthesis
- Genetic Mapping and Diversity in Plants and Animals
- Viral-associated cancers and disorders
Pingdingshan University
2025
Tongren Hospital
2025
Shanghai Jiao Tong University
2025
Chinese Academy of Sciences
2015-2024
Tianjin University of Science and Technology
2020-2024
Institute of Oceanology
2015-2024
University of Chinese Academy of Sciences
2019-2024
Qingdao National Laboratory for Marine Science and Technology
2017-2024
University of New Mexico
2024
Indian Institute of Science Education and Research Pune
2024
Asymmetric substitution is acknowledged as a straightforward yet potent approach for the optimization of small molecule acceptors (SMAs), thereby enhancing power conversion efficiency (PCE) organic solar cells (OSCs). In this work, we have successfully engineered and synthesized novel asymmetric SMA, designated Y6-R, which features rhodanine-terminated inner side-chain. devices with PM6 polymer donor, Y6-R demonstrated an impressive PCE 18.62% open-circuit voltage (Voc) 0.863 V,...
Coral gasdermin is activated by caspase 3 and involved in pathogen-induced coral death.
Abstract Pyroptosis is a newly defined gasdermin (GSDM)-dependent inflammatory type of programmed cell death. Different from mammals, which have panel pyroptotic GSDM members (e.g., GSDMA–E), teleosts possess only GSDME. The activity and regulation mechanism teleost GSDME remain to be elucidated. In this work, we investigated the Cynoglossus semilaevis (tongue sole) (CsGSDME) in association with different caspases (CASPs). We found that CsGSDME exerted bactericidal activities through its...
Gasdermin (GSDM) is a family of pore-forming proteins that, after cleavage by caspase (CASP), induce type programmed necrotic cell death called pyroptosis. E (GSDME) the only pyroptosis-inducing member GSDM existing in teleost. To date, regulation and function teleost GSDME response to bacterial infection remain elusive. In this study, we observed activation GSDME, as well multiple CASPs, turbot Scophthalmus maximus during pathogen Vibrio harveyi. Turbot has two orthologs named SmGSDMEa...
Gasdermin (GSDM) is a family of proteins that execute pyroptosis in vertebrate. In invertebrate, pyroptotic GSDM was documented only coral. Recent studies identified abundant structural homologs Mollusca, but their functions are unclear. Herein, we report functional from Pacific abalone Haliotis discus (HdGSDME). HdGSDME specifically activated by caspase 3 (HdCASP3) cleavage at two distinct sites, generating active isoforms with and cytotoxic activities. possesses evolutionarily conserved...
Necroptosis is a type of proinflammatory programmed necrosis essential for innate immunity. The receptor interacting protein kinases 1/3 (RIPK1/3) and the substrate mixed lineage kinase domain-like (MLKL) are core components necroptotic axis. activation immunological function necroptosis in fish remain elusive. Herein, we studied RIPK1/3 (PoRIPK1/3) MLKL (PoMLKL) teleost Paralichthys olivaceus . Bacterial infection increased expression MLKL. N-terminal four-helix bundle (4HB) domain PoMLKL...
Background Cordyceps militaris, an ascomycete caterpillar fungus, has been used as a traditional Chinese medicine for many years owing to its anticancer and immunomodulatory activities. Currently, artificial culturing of this beneficial fungus widely can meet the market, but systematic molecular studies on developmental stages cultured C. militaris at transcriptional translational levels have not determined. Methodology/Principal Findings We utilized high-throughput Illumina sequencing...
Ganoderma lucidum is a basidiomycete white rot fungus and of medicinal importance in China, Japan other countries the Asiatic region. To date, much research has been performed identifying ingredients lucidum. Despite its important therapeutic effects disease, little known about at genomic level. In order to gain molecular understanding this fungus, we utilized Illumina high-throughput technology sequence analyze transcriptome
Abstract Microbial production of l ‐tryptophan ( ‐trp) has received considerable attention because its diverse applications in food additives and pharmaceuticals. Overexpression rate‐limiting enzymes blockage competing pathways can effectively promote microbial ‐trp. However, the biosynthetic process remains suboptimal due to imbalanced flux distribution between central carbon tryptophan metabolism, presenting a major challenge further improvement ‐trp yield. In this study, we redistributed...
Gasdermin (GSDM) is a family of pore-forming proteins that induce pyroptosis. To date, the origin and evolution GSDM in Metazoa remain elusive. Here, we found emerged early Placozoa but absent large number invertebrates. In lower vertebrate, fish, three types GSDME, i.e., GSDMEa, GSDMEb, previously unreported type (designated GSDMEc), were idenitied. Evolutionarily, GSDMEs are distinctly separated: GSDMEa closely related to tetrapod GSDME; GSDMEb exists exclusively fish; GSDMEc forms lineage...
Rationale:The neuroinflammation is necessary for glial group initiation and clearance of damaged cell debris after nerve injury.However, the proinflammatory polarization excessive microglia amplifies secondary injury via enhancing cross-talk with astrocytes exacerbating neurological destruction spinal cord (SCI).The glucagon-like peptide-1 receptor (GLP-1R) agonist has been previously shown to have a neuroprotective effect in neurodegeneration, whereas its potency microglial inflammation SCI...
Background Agrocybe aegerita, the black poplar mushroom, has been highly valued as a functional food for its medicinal and nutritional benefits. Several bioactive extracts from A. aegerita have found to exhibit antitumor antioxidant activities. However, limited genetic resources hindered exploration of this species. Methodology/Principal Findings To facilitate research on we established deep survey transcriptome proteome mushroom. We applied high-throughput sequencing technology (Illumina)...
A novel lectin was isolated from the mushroom Agrocybe aegerita (designated AAL-2) by affinity chromatography with GlcNAc (N-acetylglucosamine)-coupled Sepharose 6B after ammonium sulfate precipitation. The AAL-2 coding sequence (1224 bp) identified performing a homologous search of five tryptic peptides MS against translated transcriptome A. aegerita. molecular mass calculated to be 43.175 kDa MS, which consistent data amino acid sequence. To analyse carbohydrate-binding properties AAL-2,...
l-Histidine is a functional amino acid with numerous therapeutic and ergogenic properties. It one of the few acids that not produced on large scale by microbial fermentation due to lack an efficient cell factory. In this study, we demonstrated engineering wild-type Escherichia coli overproduce histidine from glucose. First, removal transcription attenuation histidine-mediated feedback inhibition resulted in 0.8 g/L accumulation. Second, chromosome-based optimization expression levels...
DM9 domain was first identified in Drosophila melanogaster, and it subsequently found to integrate with or without other protein domains across a wide range of invertebrates vertebrates. In the present study, member containing (DM9CP) family from marine invertebrate Crassostrea gigas (designated CgDM9CP-1), which only composed two domains, taken as model study biological functions its molecular determinants. CgDM9CP-1 exhibit high binding specificity avidity toward d-mannose residue. It...