A5074822731- Marine Sponges and Natural Products
- Seaweed-derived Bioactive Compounds
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Protein Hydrolysis and Bioactive Peptides
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
- Biochemical and Molecular Research
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- ATP Synthase and ATPases Research
- RNA Interference and Gene Delivery
- Animal Genetics and Reproduction
- Chemical Synthesis and Analysis
- Algal biology and biofuel production
- Ubiquitin and proteasome pathways
- Microbial Metabolism and Applications
- RNA modifications and cancer
- Cancer Research and Treatments
- RNA and protein synthesis mechanisms
Beibu Gulf University
2023-2024
Chinese Academy of Agricultural Sciences
2012-2024
Southwest Medical University
2016-2024
Chinese University of Hong Kong, Shenzhen
2024
Guangzhou Medical University
2023-2024
Capital Medical University
2012-2022
Peking Union Medical College Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Shandong University of Technology
2021
Beijing YouAn Hospital
2014-2020
Background MicroRNAs (miRNAs) are short, non-coding RNAs that regulate the expression of multiple target genes. Deregulation miRNAs is common in human tumorigenesis. Low level miR-26b has been found glioma cells. However, its underlying mechanism action not determined. Methodology/Principal Findings Real-time PCR was employed to measure patients and The inversely correlated with grade glioma. Ectopic inhibited proliferation, migration invasion A binding site for identified 3′UTR EphA2....
Cloves ( Syzygium aromaticum ) have been used as a traditional Chinese medicinal herb for thousands of years. possess antiseptic, antibacterial, antifungal, and antiviral properties, but their potential anticancer activity remains unknown. In this study, we investigated the in vitro vivo antitumor effects biological mechanisms ethyl acetate extract cloves (EAEC) bioactive components responsible its activity. The EAEC on cell growth, cycle distribution, apoptosis were using human cancer...
ABSTRACT Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits potential anti‐tumor activity against many tumor cell lines. This study aims to examine the of OA on pancreatic cancer cells and its molecular mechanism. The results showed that proliferation Panc‐28 was inhibited by in concentration‐dependent manner, with an IC 50 (The half maximal inhibitory concentration) value 46.35 µg ml −1 , as determined MTT (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay. cycle...
microRNAs (miRNAs) play important role in regulating cancer stem cell self-renewal and differentiation, but the expression prolife of miRNAs glioma cells (GSCs) has not been addressed. Here, we found that CD133 positive GSCs possess a unique profile compared to negative glioblastoma cells. miR-125b, as one neuronal miRNAs, is most significantly down-regulated overexpression miR-125b inhibits proliferation reduces "stem" marker. Furthermore, two binding sites for are identified 3'UTR E2F2...
We have recently identified miR-125b upregulation in glioblastoma (GMB). The aim of this study is to determine the correlation between expression and malignant grades glioma genes targeted by miR-125b. Real-time PCR was employed measure level Cell viability evaluated cell growth colony formation soft-agar assays. apoptosis determined Hoechst 33342 staining AnnexinV-FITC assay. Luciferase assay used confirm actual binding sites p38MAPK mRNA. Western blot detect gene level. positively...
Maslinic acid (MA), a natural pentacyclictriterpene, displays cytotoxic activity on various types of cancer cells. However, its underlying mechanism is unclear. In this study, we assessed the effect MA autophagy human pancreatic cells, and potential autophagic pathway was presented. inhibited proliferation induced Panc-28 cells by altering expressions related proteins. SDS-PAGE analysis revealed that one protein band significantly down-regulated in treated with MA, identified as heat shock...
Abstract The consequence of activation status or gain/loss an X-chromosome in terms the expression tumor suppressor genes oncogenes breast cancer has not been clearly addressed. In this study, we investigated X-chromosomes a panel human cell lines, carcinoma, and adjacent mammary tissues murine epithelial sublines ranging from low to high invasive potentials. Results show that most lines were homozygous, but both benign heterozygous for highly polymorphic X-loci (IDS G6PD). On other hand,...
Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE), derived from the marine algae, is a potential α-glucosidase inhibitor for type 2 diabetes treatment. In present study, synthetic route was established as valid approach to obtain BDDE. Fluorescence spectra, circular dichroism spectra and molecular docking methods were employed elucidate inhibitory mechanisms of BDDE against α-glucosidase. The results showed that could be prepared effectively efficiently with methods. Synthetic bound induced...
Warburg effect, one of the hallmarks for cancer cells, is characterized by metabolic switch from mitochondrial oxidative phosphorylation to aerobic glycolysis. In recent years, increased expression level pyruvate kinase M2 (PKM2) has been found be culprit enhanced glycolysis in cells. However, there no agent inhibiting targeting PKM2. this study, we that Oleanolic acid (OA) induced a PKM2 PKM1, and consistently, abrogated effect Suppression OA mediated PKM2/PKM1 switch. Furthermore, mTOR...
Oleanolic acid (OA) is a nutritional component widely distributed in various vegetables. Although it has been well recognized for decades that OA exerts certain anti-tumor activity by inducing mitochondria-dependent apoptosis, still unclear what molecular signaling responsible this effect. In study, we employed cancer cell lines, A549, BXPC-3, PANC-1 and U2OS to elucidate the mechanisms underlying activity. We found activation of MAPK pathways, including p-38 MAPK, JNK ERK, was triggered...
Cancer cells are well-known to require a constant supply of protein, lipid, RNA, and DNA via altered metabolism for accelerated cell proliferation. Targeting metabolic pathways is, therefore, promising therapeutic strategy cancers. Oleanolic acid (OA) is widely distributed in dietary medicinal plants displays selective cytotoxicity cancer cells, primarily by inducing apoptosis cycle arrest. This study investigated if OA inhibited growth tumor affecting their metabolism. was found activate...
Macroalgae exhibit beneficial bioactivities for human health. Thus, the aim of present study was to examine antioxidant and anticancer potential 14 macroalgae species' extracts, namely, Gigartina pistillata, teedei, Gracilaria gracilis, sp., bursa pastoris, Colpomenia sinuosa, Cystoseira amentacea, barbata, compressa, Sargassum vulgare, Padina pavonica, Codium fragile, Ulva intestinalis, rigida, from Aegean Sea, Greece. The activity assessed using DPPH, ABTS•+, •OH, O2•- radicals' scavenging...
The rhizoid of Laminaria japonica is widely used in Chinese medicine as a treatment for diabetes. Therefore, bioactivity-tailored isolation and detailed chemical characterization was to identify the antidiabetes compounds found L. rhizoid. Liquid chromatography/mass spectrometry (LC/MS), proton NMR carbon spectra analyses demonstrated that active compound butyl-isobutyl-phthalate (BIP). BIP significant concentration-dependent, non-competitive inhibitory activity against α-glucosidase vitro,...
Glioblastoma stem cells (GSCs) are the initiating in glioblastoma multiforme (GBM) and contribute to resistance of GBM chemotherapy radiation. In present study, we investigated effects cardamonin (3,4,2,4-tetrahydroxychalcone) on self-renewal apoptosis GSCs, if its action is associated with signal transducer activator transcription 3 (STAT3) pathway. CD133(+) a kind GSCs line, was established from human tissues. Cardamonin inhibited proliferation induced CD133+ GSCs. The proapoptotic...