A5102824116- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Autoimmune Bullous Skin Diseases
- FOXO transcription factor regulation
- Genetic and rare skin diseases.
- Rheumatoid Arthritis Research and Therapies
- Viral Infectious Diseases and Gene Expression in Insects
- Dermatologic Treatments and Research
- Molecular Biology Techniques and Applications
- Wnt/β-catenin signaling in development and cancer
- Single-cell and spatial transcriptomics
- Cutaneous lymphoproliferative disorders research
- Clostridium difficile and Clostridium perfringens research
- Forensic and Genetic Research
- Gut microbiota and health
- Genomic variations and chromosomal abnormalities
- Gastrointestinal motility and disorders
- Genomics and Rare Diseases
- Immune Cell Function and Interaction
- Advanced Bandit Algorithms Research
- Gastroesophageal reflux and treatments
- Caveolin-1 and cellular processes
- Spondyloarthritis Studies and Treatments
- Cancer-related gene regulation
Shanghai East Hospital
2024-2025
Shaoxing University
2025
Tianjin University
2025
Wenzhou Medical University
2017-2024
Chinese PLA General Hospital
2024
Guangdong Medical College
2021
Affiliated Hospital of Guangdong Medical College Hospital
2021
Shanghai Public Security Bureau
2005-2018
Peking University
2013
Beijing Jishuitan Hospital
2013
Abstract Hyperactive ribosome biogenesis (RiboSis) fuels unrestricted cell proliferation, whereas genomic hallmarks and therapeutic targets of RiboSis in cancers remain elusive, efficient approaches to quantify activity are still limited. Here, we have established an silico approach conveniently score based on individual transcriptome data. By employing this novel RNA-seq data 14 645 samples from TCGA/GTEx dataset 917 294 single-cell expression profiles across 13 cancer types, observed the...
Background The rising prevalence of obesity and related metabolic disorders highlights the urgent need for innovative research approaches. Utilizing machine learning (ML) algorithms to predict obesity-associated gut microbiota validating their efficacy with specific bacterial strains could significantly enhance management strategies. Methods We leveraged microbiome data from 1,563 healthy individuals 2,043 overweight patients sourced GMrepo database. assessed anti-obesity effects...
Abstract The aim of the study was to investigate and compare clinical manifestations between HLA‐B27 + − ankylosing spondylitis ( AS ) patients in order obtain knowledge impact status on , inform treatment. A nationwide epidemiological investigation performed from November 2008 October 2010. demographic data characteristics, were collected using questionnaires laboratory assay, respectively. total 2144 (78.5% males 78.4% patients) participated this study. percentages males, with family...
Summary Variants with a relatively high frequency in the CACNA1H gene have previously been identified cases of childhood absence epilepsy (CAE) Chinese Han population most which are located exons 6 to 12. In present study we attempted further investigate whether is associated CAE. Exons 12 were sequenced samples 100 CAE trios recruited consecutively, and 191 normal human controls. Single nucleotide polymorphisms (SNPs) studied both single locus haplotype analyses 218 trios, 118 selected from...
Abstract Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member forkhead box (FOX) family, FOXC1, assumes significance embryonic development organogenesis. Furthermore, FOXC1 functions as an overexpressed transcription factor various tumors, fostering proliferation, enhancing migratory capabilities, promoting resistance, while maintaining stem-cell-like properties. Despite these implications, scant attention has been...
Considering the limitation of varying acid suppression proton pump inhibitors, this study was aimed to assess efficacy, safety, and dose-effect relationship keverprazan, a novel potassium-competitive blocker, in treatment duodenal ulcer (DU) compared with lansoprazole.A randomized, double-blind, double-dummy, multicenter, low-dose, high-dose, positive-drug parallel-controlled conducted verify non-inferiority keverprazan (20 or 30 mg) lansoprazole mg once daily for 4 6 weeks patients active...
We describe a 17-year-old man who developed penile annular and scrotal eczematoid syphilids with chancre redux. Dermoscopy showed linear-irregular hairpin vessels white scales in lesions. Histopathology displayed psoriasiform hyperplasia perivascular lymphoplasmacytic dermal infiltrate. Rapid plasma reagin Treponema pallidumparticle agglutination assays were positive. The lesions disappeared after intramuscular benzathine penicillin.
Stem cells have shown great application potential in wound repair, tissue regeneration, and disease treatment.Therefore, a full understanding of stem their related regulatory mechanisms treatment is conducive to improving the therapeutic effect cells.However, thus far, there are still many unsolved mysteries field due technical limitations, which hinder in-depth exploration wide clinical application.Single-cell sequencing (SCS) has provided very powerful unbiased insights into cell gene...
Clinicodermoscopic and immunohistochemical observation of hepatitis B virus
To introduce real-time polymerase chain reaction （real-time PCR） into the initial sample screening, to improve effectiveness of traditional trace extraction method.Serial diluted 9947A was quantified using a Rotor-Gene Q RT-PCR, and genotype determined with AmpFℓSTRTM IdentifilerTM Plus PCR kit. Thus quantitative threshold model built obtain complete STR typing from samples. In addition, 903 samples were used verify reliability.When quality concentration >0.03 ng/μL, effective could be...
Abstract Multiple Sclerosis (MS) is a progressive autoimmune disease in central nervous system (CNS) with its pathogenesis not fully understood. In the present study, we demonstrated that caveolin-1, major membrane scaffolding protein, plays critical role experimental encephalomyelitis (EAE), laboratory murine model of multiple sclerosis (MS). Immunized WT mice have increases caveolin-1 expressions serum and CNS tissues associated development. After immunization, Cav-1knockout showed...
Abstract Many evidences confirm that CSC plays an important role in tumorigenesis and drug resistance. As a member of the forkhead frame(FOX)family, FOXC1 significant embryonic development organogenesis. In addition, has been shown to be overexpressed as transcription factor variety tumors, promoting proliferation, migration ability, resistance, maintaining stem-cell like properties. However, there are few studies on its ESCC. We found expression was upregulated ESCC correlated with poor...
To analyze three cases with partial 21q trisomy, and correlate their genotypes phenotypes.G-banding chromosomal analysis single nucleotide polymorphism (SNP array) were performed for the parents.SNP array has detected trisomy in one mother, variable size location of duplications. Case 1 harbored a 12.35 Mb duplication at 21q22.11q22.3, which spanned Down syndrome critical region. 2 35.32 9p24.3p13.3 14.42 21q11.2q21.3, former spanning 9p region excluding region, was inherited from his...
To analyze the audiological features and genetic background of patients carrying mitochondrial DNA(mtDNA) 1555A>G mutation factors which may influence extent nonsyndromic hearing loss associated with mutation.A literature search was carried out on databases including PubMed, CNKI, Wanfang, VIP. Combined author's data, clinical patients, in particular characteristics, were summarized.A total 857 effective cases collected analyzed. A significantly correlation identified between history...
Objective To detect mutations in the ARAD1 gene a pedigree with dyschromatosis symmetrica hereditaria (DSH) . Methods Genomic DNA was extracted from peripheral blood of 8 family members (including 5 patients DSH and 3 unaffected members) DSH, as well 100 unrelated healthy controls. All 15 exon sequences ADAR1 were amplified by polymerase chain reaction (PCR) followed direct sequencing. Then, detected comparison standard sequence Genebank. Results A nonsense mutation C.1420C > T...
Chinese Han ethnic group (n = 165)