A5084288880- Antibiotic Resistance in Bacteria
- interferon and immune responses
- Cancer Mechanisms and Therapy
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- Peptidase Inhibition and Analysis
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Phytochemistry and Bioactive Compounds
- Bacterial Infections and Vaccines
- Natural product bioactivities and synthesis
- Beetle Biology and Toxicology Studies
- Chromatin Remodeling and Cancer
- Cancer, Hypoxia, and Metabolism
- Infections and bacterial resistance
- Galectins and Cancer Biology
- Protein Degradation and Inhibitors
- Antibiotics Pharmacokinetics and Efficacy
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Pharmaceutical and Antibiotic Environmental Impacts
Shandong First Medical University
2025
Ningbo University
2021-2022
Ningbo Medical Center Lihuili Hospital
2013-2022
OBJECTIVE: Studies have suggested that miR-21-5p and WWC2 are key players in most cancer types, yet the underlying mechanisms lung adenocarcinoma (LUAD) remain elusive. This study made in-depth research on two factors-dependent LUAD occurrence development. METHODS: Bioinformatics methods were employed to identify miRNA its target gene of interest. In all, 20 pairs tumor tissue samples matched adjacent normal along with 5 cell lines collected for evaluating aberrant expression WWC2....
Objective To study the effects of saikosaponin D (SSD) on proliferation and apoptosis in human non-small cell lung cancer lines, to explore underlying mechanisms. Methods Following treatment with D, A549 H1299 cells were assessed for anti-proliferation using cycle kit-8 assays, changes nuclear morphology 4′,6-diamidino-2-phenylindole (DAPI) staining, annexin V/propidium iodide double staining. Proliferation- apoptosis-related proteins detected by immunoblotting. Results Saikosaponin had...
Background There is a paucity of studies using clinical characteristics and whole-genome sequencing together to fully identify the risk factors patients with Klebsiella pneumoniae (KP) bloodstream infection (BSI). Methods We retrospectively analyzed microbiological KP BSI. Isolates were processed Illumina NGS, relevant bioinformatics analysis was conducted (multi-locus sequence typing, serotype, phylogenetic reconstruction, detection antibiotic resistance, virulence genes). A logistic...
Apoptosis of human pulmonary artery endothelial cells (HPAECs) is the initial step and triggering event for hypertension (PH). However, little known about actions nicorandil on HPAECs in vitro. In present study, we investigated anti-apoptotic effect exposed to hypoxia, explored underlying mechanism(s) action. Cell viability was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Annexin V propidium iodide staining, Hoechst 33342 staining assay were employed...
Emerging research shows that the Programmed Cell Death Protein 1/Programmed Ligand 1(PD-1/PD-L1) pathway modulates antiviral response following influenza A virus (IAV) infection, and there is a need to understand further role of PD-1/PD-L1 signaling in IAV infection. BALB/c mice were infected with different types establish models varying degrees infection (mild severe). The pretreated or without PD-1 antagonist evaluate general activity, degree weight change, viral titer, pathological...
The spread of the plasmid-mediated colistin resistance gene mcr-1 poses a significant public health threat. Little information is available on development high-level colistin-resistant mutants (HLCRMs) in MCR-1-producing Escherichia coli (MCRPEC). present study was designed to evaluate impact chromosomal modifications pmrAB, phoPQ, and mgrB combined with E. coli.Five MCRPEC three non-MCRPEC (E. ATCC25922 two plasmid-curing) strains were used. HLCRMs selected through multi-stepwise exposure....
The programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) signaling pathway is significantly upregulated in influenza virus infection, which impairs the antiviral response. Blocking this may reduce damage, lower titer lung tissue, and alleviate symptoms of infection to promote recovery. In addition enhanced viral immune response, using checkpoint inhibitors controversial, aim study was identify key factors regulatory mechanisms PD-1 blockade response microenvironment infection.
There is a paucity of published data to evaluate the efficacy and safety imipenem, cefepime piperacillin/tazobactam dosing regimens against bloodstream infections caused by Klebsiella aerogenes (BSIs-Kae) Enterobacter cloacae complex (BSIs-Ecc) in patients with various degrees renal function.Pathogens were isolated from China's blood bacterial resistant investigation network. The piperacillin simulated intermittent infusion extended infusion. Monte Carlo simulation was performed calculate...
Background. The Ron receptor tyrosine kinase (RON) can act as a protooncogene and may play prominent role in the initiation development of lung cancer. microRNAs (miRNA) are master regulators gene expression through direct or indirect regulation, impact all aspects cell biology. Methods. Nonsmall-cell cancer (NSCLC) samples small-cell (SCLC) were stratified based on RON to identify miRNA profiles associated with levels, differentially expressed regulated by screened out, their biological...
Abstract Background: The programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) signaling pathway is significantly upregulated in severe influenza virus infection, which impairs the immune system and causes increased tissue inflammation damage. Blocking this will reduce damage, lower titer lung tissue, alleviate symptoms of infection to promote recovery. aim study was identify key factors regulatory mechanisms PD-1 checkpoint blockade–responsive microenvironment infection. Methods: A BALB/c...