A5100613122- CRISPR and Genetic Engineering
- Biochemical and Molecular Research
- RNA modifications and cancer
- RNA Research and Splicing
- Advanced Photonic Communication Systems
- Optical Network Technologies
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Histone Deacetylase Inhibitors Research
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Innovation and Socioeconomic Development
- Adenosine and Purinergic Signaling
- Solid State Laser Technologies
- Optical properties and cooling technologies in crystalline materials
- Cancer Mechanisms and Therapy
- Advanced biosensing and bioanalysis techniques
- Neurological Disease Mechanisms and Treatments
- RNA regulation and disease
- Lightning and Electromagnetic Phenomena
- Nanoplatforms for cancer theranostics
- Advanced Fiber Laser Technologies
- Congenital heart defects research
- Peptidase Inhibition and Analysis
Shanghai Jiao Tong University
2024-2025
Qingdao University
2025
Nanjing Normal University
2024
ShanghaiTech University
2019-2024
University of Wisconsin–Madison
2016-2024
Jiangsu University
2024
Xi'an University of Architecture and Technology
2021-2024
Shenyang Agricultural University
2024
Huazhong University of Science and Technology
2024
Tsinghua University
2020-2023
Neonatal mouse cardiomyocytes undergo a metabolic switch from glycolysis to oxidative phosphorylation, which results in significant increase reactive oxygen species production that induces DNA damage. These cellular changes contribute cardiomyocyte cell cycle exit and loss of the capacity for cardiac regeneration. The mechanisms regulate this have been relatively unexplored. Current evidence suggests elevated ischemic tissues occurs as result accumulation mitochondrial metabolite succinate...
Gastric cancer (GC) is one of the leading causes mortality in world. In addressing need treatments for relapsed disease, we report identification an existing U.S. Food and Drug Administration-approved small-molecule drug to repurpose GC treatment. Auranofin (AF), clinically used treat rheumatic arthritis, but it exhibited preclinical efficacy cells. By increasing intracellular reactive oxygen species (ROS) levels, AF induces a lethal endoplasmic reticulum stress response mitochondrial...
Perception of facial identity and emotional expressions is fundamental to social interactions. Recently, interest in age associated changes the processing faces has grown rapidly. Due lack older stimuli, most previous age-comparative studies only used young which might cause own-age advantage. None existing Eastern face stimuli databases contain images different groups (e.g. adult faces). In this study, a database that comprises 110 Chinese adults displaying eight (Neutral, Happiness, Anger,...
Abstract No RNA is completely naked from birth to death. RNAs function with and are regulated by a range of proteins that bind them. Therefore, the development innovative methods for studying RNA–protein interactions very important. Here, we developed new tool, CRISPR-based RNA-United Interacting System (CRUIS), which captures in living cells combining power CRISPR PUP-IT, novel proximity targeting system. In CRUIS, dCas13a used as tracker target specific RNAs, while enzyme PafA fused label...
The "undruggable" oncogene MYC supports cancer cell proliferation and survival through parallel induction of multiple anabolic processes. Here we find that inhibiting CTP synthase (CTPS) selectively decreases viability induces DNA replication stress in MYC-overexpressing cells. MYC-driven rRNA synthesis caused the selective upon CTPS inhibition. Combined inhibition ataxia telangiectasia Rad3-related protein (ATR) is synthetically lethal cells, promoting death vitro decreasing tumor growth...
Abstract Liquid‒liquid phase separation (LLPS) is a ubiquitous process in which proteins, RNA, and biomolecules assemble into membrane‐less compartments, playing important roles many biological functions diseases. The current knowledge on the biophysical biochemical principles of LLPS largely from vitro studies; however, physiological environment living cells complex not at equilibrium. characteristics intracellular dynamics their remain to be resolved. Here, by using single‐particle...
With the development of Internet Things, cloud networking, and 4K/8K high-definition video, global internet traffic has seen a dramatic increase. This surge in placed higher demands on performance optical networks, featuring data rates, lower latency, cost. The passive network (PON) is representative scenario access networks. Issues such as burst-mode detection upstream PON scenarios, flexible rate allocation downstream simplification hardware complexity at unit (ONU) side have attracted...
We present a novel, to the best of our knowledge, design chromatic confocal displacement system (CCDS) based on spectral stripe. In this system, light collected by dispersive lens is shaped Powell and then diffracted onto detector in form thin straight The variant converted into change stripe positions detector. Unlike profile or diffractive spot, significantly increases pixel number for analysis effectively suppresses random noises. Simulation experiment results show that positional...
Introduction: Triple-negative breast cancer (TNBC) is known for its high malignancy, limited clinical treatment options, and poor chemotherapy outcomes. Although some advancements have been made using nanotechnology-based TNBC treatment, the controlled on-demand release of chemotherapeutic drugs at tumor site remains a challenge. Methods: We manufactured DOX/BaTiO 3 @cRGD-Lip (DBRL) nanoparticles as an ultrasound (US)-controlled platform targeting delivery Doxorubicin (DOX) treatment. The...
ABSTRACT African swine fever (ASF) is a highly infectious and lethal disease, leading to enormous losses in the pig industry. K205R, non-structural protein of ASF virus (ASFV), abundantly expressed at early stages viral infection induces strong immune response. In our previous study, five strains K205R-specific nanobodies (Nbs) were screened through phage display technology, among which Nb1, Nb14, Nb35, Nb82 exhibited good affinity. present above four Nbs successfully HEK293T cells...
Guanosine triphosphate (GTP) is a building block for DNA and RNA, plays pivotal role in various cellular functions, serving as an energy source, enzyme cofactor key component of signal transduction. The activity the rate‐limiting de novo GTP synthesis, inosine monophosphate dehydrogenase (IMPDH), regulated by nucleotide binding. Recent studies have illuminated that IMPDH octamers can assemble into linear polymers, adding another dimension to its enzymatic regulation. This polymerisation...
Rapamycin, a mammalian target of rapamycin (mTOR) signaling inhibitor, inhibits cancer cell proliferation and tumor formation, including in nasopharyngeal carcinoma (NPC), which we proved previous study. However, whether affects stem cells (CSCs) is unclear. In examining samples NPCs, found regions CD44-positive co-expressing the biomarker OCT4, suggesting presence CSCs. Following this, used double-label immunohistochemistry to identify mTOR pathway was activated CSCs NPCs. We CCK-8 assay...
Electrochemiluminescence (ECL) has numerous merits such as high sensitivity and specificity for the detection applications on pharmacy, food safety, immunoassay, disease diagnosis, environmental monitoring, nucleic acid assay, clinical treatment. However, insufficiency of ECL luminescent reagents is restricting their adoption complex systems or multi-analyte detections. In this work, to improve selectivity discrimination with one less reagent, we employed multi-stopband photonic crystals...
Introduction: Inosine monophosphate dehydrogenase 1 (IMPDH1) is a critical enzyme in the retina, essential for correct functioning of photoreceptor cells. Mutations IMPDH1 have been linked to autosomal dominant retinitis pigmentosa subtype 10 (adRP-10), genetic eye disorder. Some these mutations such as Asp226Asn (D226N) lead assembly large filamentous structures termed cytoophidia. D226N also gives resistance feedback inhibition by GDP/GTP. This study aims emulate adRP-10 condition with...
Dysfunction of noradrenergic (NA) neurons is associated with a number neuronal disorders. Diverse subtypes can be generated by direct reprogramming. However, it still unknown how to convert non-neuronal cells into NA neurons. Here, we show that seven transcription factors (TFs) (Ascl1, Phox2b, AP-2α, Gata3, Hand2, Nurr1, and Phox2a) are able astrocytes fibroblasts induced (iNA) These iNA express the genes required for biosynthesis, release, re-uptake noradrenaline. Moreover, fire action...
Insulin resistance precedes metabolic syndrome which increases the risk of type 2 diabetes and cardiovascular disease. However, there is a lack safe long-lasting methods for prevention treatment insulin resistance. Gut microbiota dysbiosis can lead to associated glucose lipid dysfunction. Thus, role gut in diseases has garnered growing interest. Curcumin, active ingredient tropical plant Curcuma longa, excellent prospects diseases. due extremely low bioavailability curcumin, mechanisms by...