A5051601604- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Cardiac Valve Diseases and Treatments
- HIV Research and Treatment
- Cardiac electrophysiology and arrhythmias
- Congenital gastrointestinal and neural anomalies
- Calcium signaling and nucleotide metabolism
- scientometrics and bibliometrics research
- T-cell and Retrovirus Studies
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Animal Disease Management and Epidemiology
- Cardiovascular Function and Risk Factors
- Renal and related cancers
- Nicotinic Acetylcholine Receptors Study
- Heart Rate Variability and Autonomic Control
- HIV-related health complications and treatments
- RNA and protein synthesis mechanisms
- Birth, Development, and Health
- Signaling Pathways in Disease
- Academic and Historical Perspectives in Psychology
University of Wisconsin–Madison
2020-2023
Fort Lewis College
2018
Neonatal mouse cardiomyocytes undergo a metabolic switch from glycolysis to oxidative phosphorylation, which results in significant increase reactive oxygen species production that induces DNA damage. These cellular changes contribute cardiomyocyte cell cycle exit and loss of the capacity for cardiac regeneration. The mechanisms regulate this have been relatively unexplored. Current evidence suggests elevated ischemic tissues occurs as result accumulation mitochondrial metabolite succinate...
Sympathetic innervation influences homeostasis, repair, and pathology in the cardiac ventricles; contrast, parasympathetic is considered to have minimal contribution influence ventricles. Here, we use genetic models, whole-mount imaging, three-dimensional modeling define nerve architecture during development, disease, regeneration. Our approach reveals that nerves extensively innervate Furthermore, identify sympathetic axons develop synchronously are bundled throughout We further investigate...
Abstract Leucine-rich repeat containing 10 (LRRC10) is a cardiomyocyte-specific protein, but its role in cardiac biology little understood. Recently Lrrc10 was identified as required for endogenous regeneration zebrafish; however, whether LRRC10 plays mammalian heart remains unclear. In this study, we demonstrate that –/– knockout mice exhibit loss of the neonatal mouse regenerative response, marked by reduced cardiomyocyte cytokinesis and increased binucleation. Interestingly, deletion...
The aim of our study was to determine whether HIV-1 DNA level before antiretroviral therapy (ART) associated with short- and long-term virological immunological responses. Patients starting first-line protease inhibitor-containing regimens were enrolled in a prospective multicentre cohort 1998–99. quantified using real-time PCR at baseline after 1 year ART. association between responses 7 years on ART studied multivariate regression models along other biological clinical variables....
ABSTRACT Adult mammalian cardiomyocytes have limited proliferative potential, and after myocardial infarction (MI), injured cardiac tissue is replaced with fibrotic scar rather than functioning myocardium. In contrast, the neonatal mouse heart possesses a regenerative capacity governed by cardiomyocyte proliferation; however, metabolic switch from glycolysis to fatty acid oxidation during postnatal development results in loss of this capacity. Interestingly, sarcomere isoform also takes...
Cardiovascular disease outranks all other causes of death and is responsible for a staggering 31% mortalities worldwide. This manifests in cardiac injury, primarily the form an acute myocardial infarction. With little resilience following once healthy tissue will be replaced by fibrous, non-contractile scar often prelude to heart failure. To identify novel treatment options regenerative medicine, research has focused on vertebrates with innate capabilities. One such model organism neonatal...
Cardiovascular disease outranks all other causes of death and is responsible for a staggering 31% mortalities worldwide. This manifests in cardiac injury, primarily the form an acute myocardial infarction. With little resilience following once healthy tissue will be replaced by fibrous, non-contractile scar often prelude to heart failure. To identify novel treatment options regenerative medicine, research has focused on vertebrates with innate capabilities. One such model organism neonatal...
Cardiac nerves regulate neonatal mouse heart regeneration and are susceptible to pathological remodeling following adult injury. Understanding cardiac nerve can lead new strategies promote repair. Our current understanding of architecture has been limited two-dimensional analysis. Here, we use genetic models, whole-mount imaging, three-dimensional modeling tools define neurovascular association during development, disease, regeneration. results demonstrate that sequentially associate with...
Worldwide, congenital anomalies of the kidney and urinary tract (CAKUT) are leading cause chronic renal disease in children play a significant causative factor pediatric end‐stage disease. Current research being conducted is reliant upon animal model systems to monitor embryonic development; however, system modeling human organogenesis necessity order elucidate intertwined genetic molecular networks related CAKUT pathogenesis. One known correlation mutation within gene encoding for RET...
Insights regarding the regulated secretion of insulin from pancreatic β‐cells has implications for understanding diabetes and regulation glucose metabolism. Piccolo is a high‐molecular weight protein part multi‐molecular complex involved in secretion. Interestingly, genetic variants gene ( PCLO ) have been modestly associated with increased risk early‐onset type II among Pima Indians. may regulate through novel mechanism by serving as Ca 2+ sensor that interacts L‐type voltage‐dependent...
The human T-lymphotropic virus type 1 (HTLV-1) RNA genome includes two programmed -1 ribosomal frameshift (-1 PRF) sites. These sites allow ribosomes access to alternate reading frames encoding critical viral enzymes. gag-proframeshift site a slippery sequence, spacer, and stem-loop structure. How the acts promote frameshifting is unclear. Previous HTLV-2 research showed that changes gag-pro thermodynamic stability influenced its efficiency modest degree. There substantial conservation...